3.4.21.B6: prostasin

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For detailed information about prostasin, go to the full flat file.

Reaction

endoprotease activity. Trypsin-like enzymatic activity =

Synonyms

CAP-1, CAP1, CAP1/PRSS8, channel activating protease 1, channel activating protease-1, channel-activating protease 1, channel-activating protease-1, LD47230p, prostasin, prostasin/PRSS8, PRSS8, S01.159, tracheal-prostasin

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.B6 prostasin

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Results	in table
17	Activating Compound
5	AA Sequence
13	Application
1	CAS Registry Number
21	Cloned(Commentary)
3	Crystallization (Commentary)
686	Disease/ Diagnostics
7	Expression
28	General Information
69	Inhibitors
36	Ki Value [mM]
18	KM Value [mM]
14	Localization
18	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
57	Organism
3	pH Optimum
1	pH Range
1	pI Value
6	Posttranslational Modification
10	Protein Variants
13	Purification (Commentary)
1	Reaction
6	Reaction Type
57	Reference
148	Source Tissue
44	Substrates and Products (Substrate)
5	Subunits
31	Synonyms
17	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.4.21.B6 - prostasin

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

hanging drop vapor diffusion method. Active prostasin is crystallized, and the structure is determined to 1.45 A resolution. These apoprotein crystals are soaked with nafamostat, allowing the structure of the inhibited acyl-enzyme intermediate structure to be determined to 2.0 A resolution

Homo sapiens

Q16651

693192

structure of the extracellular portion of the membrane associated serine protease solved to high resolution in complex with a nonselective d-FFR chloromethyl ketone inhibitor, in an apo form, in a form where the apo crystal is soaked with the covalent inhibitor camostat and in complex with the protein inhibitor aprotinin. It is also crystallized in the presence of the divalent cation Ca2+

Homo sapiens

Q16651

695021

X-ray crystal structures of prostasin with small molecule inhibitors

Homo sapiens

Q16651

691307