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3.4.21.B6: prostasin

This is an abbreviated version!
For detailed information about prostasin, go to the full flat file.

Word Map on EC 3.4.21.B6

Reaction

endoprotease activity. Trypsin-like enzymatic activity =

Synonyms

CAP-1, CAP1, CAP1/PRSS8, channel activating protease 1, channel activating protease-1, channel-activating protease 1, channel-activating protease-1, LD47230p, prostasin, prostasin/PRSS8, PRSS8, S01.159, tracheal-prostasin

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.B6 prostasin

Expression

Expression on EC 3.4.21.B6 - prostasin

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
application of ibuprofen increases prostasin expression in the UROtsa and the B6Tert-1 cells
high-fat diet triggers the suppression of the enzyme expression by inducing endoplasmic reticulum stress
prostasin expression increases during human Caco-2 cell differentiation and barrier formation
prostasin is down-regulated in human prostate, breast, and gastric cancers and invasive cancer cell lines
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prostasin is highly overexpressed in ovarian cancer cell lines
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the mRNA level of prostasin is slightly but significantly decreased in both mild/moderate dysplasia and severe dysplasia and in carcinomas compared to normal tissue from the same individual
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