3.4.21.B25: PACE4 proprotein convertase
This is an abbreviated version!
For detailed information about PACE4 proprotein convertase, go to the full flat file.
Word Map on EC 3.4.21.B25
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3.4.21.B25
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convertases
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furin
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prohormone
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endoproteases
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furin-deficient
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furin-like
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alpha1-pdx
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dibasic
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pro-proteins
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alpha1-antitrypsin
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portland
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endoproteolysis
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diagnostics
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kexin
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kexin-like
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ski-1
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cys-rich
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medicine
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subtilisin-related
- 3.4.21.B25
-
convertases
- furin
-
prohormone
- endoproteases
-
furin-deficient
-
furin-like
- alpha1-pdx
-
dibasic
-
pro-proteins
- alpha1-antitrypsin
- portland
-
endoproteolysis
- diagnostics
- kexin
-
kexin-like
- ski-1
-
cys-rich
- medicine
-
subtilisin-related
Reaction
releases mature proteins from their proproteins by cleavage of Arg-Xaa-Yaa-Arg-Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys =
Synonyms
PACE 4, PACE-4, PACE4, PACE4/SPC4, paired basic amino acid cleaving enzyme 4, paired basic amino acid-cleaving enzyme 4, paired basic amino-acid-cleaving enzyme-4, PC7, proprotein convertase PACE4, S08.075, SPC4, subtilisin-like proprotein convertase, subtilisin-like proprotein convertase 4, subtilisin-like proprotein convertase PACE4, XPACE4
ECTree
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Source Tissue
Source Tissue on EC 3.4.21.B25 - PACE4 proprotein convertase
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maximum expression of XPACE4 at the early blastula stage
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expression pattern of bone-related genes by RT-PCR/quantitative real-time PCR
presence of PACE4 protein is restricted to chondrocytes of healthy cartilage, whereas the expression is increased in osteoarthritis cartilage
enzyme expression in non-small cell lung cancer cells is significantly higher than in normal lung cell and tissues
enriched in vegetal halves, with no significant asymmetrical distribution between dorsal and ventral halves
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PACE4 is limited to the glia and the retina of the optic nerve head
the enzyme regulates apoptosis in human pancreatic cancer PANC-1 cells via the mitochondrial signaling pathway
additional information
enriched in vegetal masses, with no significant asymmetrical distribution between dorsal and ventral halves
enzyme expression in non-small cell lung cancer cells is significantly higher than in normal lung cell and tissues
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PACE4 is intensely expressed in the submandibular epithelium-derived cells including proacinar, terminal tubular, and presumptive ductal cells in the prenatal submandibular gland