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3.4.21.B25: PACE4 proprotein convertase

This is an abbreviated version!
For detailed information about PACE4 proprotein convertase, go to the full flat file.

Word Map on EC 3.4.21.B25

Reaction

releases mature proteins from their proproteins by cleavage of Arg-Xaa-Yaa-Arg-Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys =

Synonyms

PACE 4, PACE-4, PACE4, PACE4/SPC4, paired basic amino acid cleaving enzyme 4, paired basic amino acid-cleaving enzyme 4, paired basic amino-acid-cleaving enzyme-4, PC7, proprotein convertase PACE4, S08.075, SPC4, subtilisin-like proprotein convertase, subtilisin-like proprotein convertase 4, subtilisin-like proprotein convertase PACE4, XPACE4

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.B25 PACE4 proprotein convertase

Source Tissue

Source Tissue on EC 3.4.21.B25 - PACE4 proprotein convertase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
maximum expression of XPACE4 at the early blastula stage
Manually annotated by BRENDA team
-
expression pattern of bone-related genes by RT-PCR/quantitative real-time PCR
Manually annotated by BRENDA team
-
PACE4-C, PACE4-CS and PACE4-C
Manually annotated by BRENDA team
presence of PACE4 protein is restricted to chondrocytes of healthy cartilage, whereas the expression is increased in osteoarthritis cartilage
Manually annotated by BRENDA team
-
hypertrophic chondrocyte
Manually annotated by BRENDA team
at the gastrula stage
Manually annotated by BRENDA team
-
PACE4-C and PACE4-C
Manually annotated by BRENDA team
enzyme expression in non-small cell lung cancer cells is significantly higher than in normal lung cell and tissues
Manually annotated by BRENDA team
at tailbud stage
Manually annotated by BRENDA team
enriched in vegetal halves, with no significant asymmetrical distribution between dorsal and ventral halves
Manually annotated by BRENDA team
-
PACE4 is limited to the glia and the retina of the optic nerve head
Manually annotated by BRENDA team
the enzyme regulates apoptosis in human pancreatic cancer PANC-1 cells via the mitochondrial signaling pathway
Manually annotated by BRENDA team
-
PACE4 is limited to the glia and the retina of the optic nerve head
Manually annotated by BRENDA team
lower levels
Manually annotated by BRENDA team
additional information