3.4.21.B25: PACE4 proprotein convertase
This is an abbreviated version!
For detailed information about PACE4 proprotein convertase, go to the full flat file.
Word Map on EC 3.4.21.B25
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3.4.21.B25
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convertases
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furin
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prohormone
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endoproteases
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furin-deficient
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furin-like
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alpha1-pdx
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dibasic
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pro-proteins
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alpha1-antitrypsin
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portland
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endoproteolysis
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diagnostics
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kexin
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kexin-like
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ski-1
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cys-rich
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medicine
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subtilisin-related
- 3.4.21.B25
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convertases
- furin
-
prohormone
- endoproteases
-
furin-deficient
-
furin-like
- alpha1-pdx
-
dibasic
-
pro-proteins
- alpha1-antitrypsin
- portland
-
endoproteolysis
- diagnostics
- kexin
-
kexin-like
- ski-1
-
cys-rich
- medicine
-
subtilisin-related
Reaction
releases mature proteins from their proproteins by cleavage of Arg-Xaa-Yaa-Arg-Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys =
Synonyms
PACE 4, PACE-4, PACE4, PACE4/SPC4, paired basic amino acid cleaving enzyme 4, paired basic amino acid-cleaving enzyme 4, paired basic amino-acid-cleaving enzyme-4, PC7, proprotein convertase PACE4, S08.075, SPC4, subtilisin-like proprotein convertase, subtilisin-like proprotein convertase 4, subtilisin-like proprotein convertase PACE4, XPACE4
ECTree
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Inhibitors
Inhibitors on EC 3.4.21.B25 - PACE4 proprotein convertase
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3,3',3'',3'''-(benzene-1,4-diyldimethanetriyl)tetrakis(4-hydroxy-2H-chromen-2-one)
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3,3'-(1,3-benzodioxol-5-ylmethanediyl)bis(4-hydroxy-2H-chromen-2-one)
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3,3'-(2,3-dihydro-1H-inden-5-ylmethanediyl)bis(4-hydroxy-2H-chromen-2-one)
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A23187
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if reticulocalbin-3 binds to proPACE4 transiently during its biosynthesis, this Ca2+-specific ionophore can block the maturation of proPACE4 to PACE4, accumulation of the proPaCE4-recticulocalbin-3 complex in the cells
alpha1-antitrypsin variant PDX
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50% inhibition above 0.00002 mM, forms a complex with the enzyme
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alpha1-antitrypsin variant Portland
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contains a minimal consensus sequence (Arg-X-X-Arg) for efficient cleavage by furin in its reactive site loop
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alpha1-antitrypsin variant RRRRSA
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rat alpha-antitrypsin showing substitution of Arg-Arg-Arg-Arg for Ala-Val-Pro-Met352 at P4-P1 and Ala for Leu354 at P2'
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alpha1-antitrypsin variant RRRRSL
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rat alpha-antitrypsin showing substitution of Arg-Arg-Arg-Arg for Ala-Val-Pro-Met352 at P4-P1
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antisense oligo 5
depletes XPACE4 to 5-10% of control levels; depletes XPACE4 to 5-10% of control levels
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50% inhibition at 0.000005 mM, forms a complex with the enzyme
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additional information
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alpha1-proteinase inhibitor-Portland and alpha1-proteinase inhibitor-Pittsburgh have little effect on PACE4 activity
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additional information
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not inhibited by leupeptin and soybean trypsin inhibitor
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