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3.4.21.B25: PACE4 proprotein convertase

This is an abbreviated version!
For detailed information about PACE4 proprotein convertase, go to the full flat file.

Word Map on EC 3.4.21.B25

Reaction

releases mature proteins from their proproteins by cleavage of Arg-Xaa-Yaa-Arg-Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys =

Synonyms

PACE 4, PACE-4, PACE4, PACE4/SPC4, paired basic amino acid cleaving enzyme 4, paired basic amino acid-cleaving enzyme 4, paired basic amino-acid-cleaving enzyme-4, PC7, proprotein convertase PACE4, S08.075, SPC4, subtilisin-like proprotein convertase, subtilisin-like proprotein convertase 4, subtilisin-like proprotein convertase PACE4, XPACE4

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.B25 PACE4 proprotein convertase

KI Value

KI Value on EC 3.4.21.B25 - PACE4 proprotein convertase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.012
2-(11-hydroxy-3-oxo-3H-dibenzo[c,h]xanthen-7-yl)benzoic acid
-
0.0083
3,3',3'',3'''-(benzene-1,4-diyldimethanetriyl)tetrakis(4-hydroxy-2H-chromen-2-one)
-
0.014
3,3'-(1,3-benzodioxol-5-ylmethanediyl)bis(4-hydroxy-2H-chromen-2-one)
-
0.013
3,3'-(2,3-dihydro-1H-inden-5-ylmethanediyl)bis(4-hydroxy-2H-chromen-2-one)
-
0.000013
Ac-(D)LLLLRVK-2,3-dehydroagmatine
pH 7.5, 37°C
0.0000049
Ac-(D)LLLLRVK-4-amidinobenzylamide
pH 7.5, 37°C
0.000024
Ac-(D)LLLLRVKR-NH2
pH 7.5, 37°C
0.00011
Ac-LLLLR-((2S)-amino-3S-guanidinobutyryl)-KR-NH2
pH and temperature not specified in the publication
0.00051
Ac-LLLLR-((2S,3R)-diaminobutyryl)-KR-NH2
pH and temperature not specified in the publication
0.00027
Ac-LLLLR-((2S,3S)-diaminobutyryl)-KR-NH2
pH and temperature not specified in the publication
0.00066
Ac-LLLLR-(2,3-diaminobutyryl)-KR-NH2
pH and temperature not specified in the publication
0.00216
Ac-LLLLR-(2,3-diaminopropionyl)-KR-NH2
pH and temperature not specified in the publication
0.00055
Ac-LLLLR-(2-amino-3-guanidinopropionyl)-KR-NH2
pH and temperature not specified in the publication
0.000087
Ac-LLLLR-(2-amino-4-guanidinobutyryl)-KR-NH2
pH and temperature not specified in the publication
0.000105
Ac-LLLLR-Orn-KR-NH2
pH and temperature not specified in the publication
0.000195
Ac-LLLLRAKR-NH2
pH and temperature not specified in the publication
0.000083
Ac-LLLLRKKR-NH2
pH and temperature not specified in the publication
0.000088
Ac-LLLLRRKR-NH2
pH and temperature not specified in the publication
0.0000053
Ac-LLLLRVK-2,3-dehydroagmatine
pH 7.5, 37°C
0.0000031
Ac-LLLLRVK-4-amidinobenzylamide
pH 7.5, 37°C
0.000022
Ac-LLLLRVKR-NH2
0.00001
Ac-[C8](D)LLLLRVK-4-amidinobenzylamide
pH 7.5, 37°C
0.000055
Ac-[C8](D)LLLLRVKR-NH2
pH 7.5, 37°C
0.000003
Ac-[C8]LLLLRVK-4-amidinobenzylamide
pH 7.5, 37°C
0.000023
Ac-[C8]LLLLRVKR-NH2
pH 7.5, 37°C
0.0000027
Ac-[PEG2](D)LLLLRVK-4-amidinobenzylamide
pH 7.5, 37°C
0.000029
Ac-[PEG2]LLLLRVKR-NH2
pH 7.5, 37°C
0.000031
Ac-[PEG4]LLLLRVKR-NH2
pH 7.5, 37°C
0.000012
Ac-[PEG8](D)LLLLRVK-2,3-dehydroagmatine
pH 7.5, 37°C
0.0000029
Ac-[PEG8](D)LLLLRVK-4-amidinobenzylamide
pH 7.5, 37°C
0.000045
Ac-[PEG8](D)LLLLRVKR-NH2
pH 7.5, 37°C
0.0000028
Ac-[PEG8]LLLLRVK-2,3-dehydroagmatine
pH 7.5, 37°C
0.0000007
Ac-[PEG8]LLLLRVK-4-amidinobenzylamide
pH 7.5, 37°C
0.000019
Ac-[PEG8]LLLLRVKR-NH2
pH 7.5, 37°C
0.0000045
H2N-[C8](D)LLLLRVK-2,3-dehydroagmatine
pH 7.5, 37°C
0.00003
H2N-[C8](D)LLLLRVKR-NH2
pH 7.5, 37°C
0.0000034
H2N-[C8]LLLLRVK-2,3-dehydroagmatine
pH 7.5, 37°C
0.000001
H2N-[C8]LLLLRVK-4-amidinobenzylamide
pH 7.5, 37°C
0.000045
H2N-[C8]LLLLRVKR-NH2
pH 7.5, 37°C
0.000056
[C8](D)LLLLRVK-2,3-dehydroagmatine
pH 7.5, 37°C
0.000024
[C8](D)LLLLRVK-4-amidinobenzylamide
pH 7.5, 37°C
0.0001
[C8](D)LLLLRVKR-NH2
pH 7.5, 37°C
0.000045
[C8]LLLLRVK-2,3-dehydroagmatine
pH 7.5, 37°C
0.000016
[C8]LLLLRVK-4-amidinobenzylamide
pH 7.5, 37°C
0.000085
[C8]LLLLRVKR-NH2
pH 7.5, 37°C