3.4.21.B25: PACE4 proprotein convertase
This is an abbreviated version!
For detailed information about PACE4 proprotein convertase, go to the full flat file.
Word Map on EC 3.4.21.B25
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3.4.21.B25
-
convertases
-
furin
-
prohormone
-
endoproteases
-
furin-deficient
-
furin-like
-
alpha1-pdx
-
dibasic
-
pro-proteins
-
alpha1-antitrypsin
-
portland
-
endoproteolysis
-
diagnostics
-
kexin
-
kexin-like
-
ski-1
-
cys-rich
-
medicine
-
subtilisin-related
- 3.4.21.B25
-
convertases
- furin
-
prohormone
- endoproteases
-
furin-deficient
-
furin-like
- alpha1-pdx
-
dibasic
-
pro-proteins
- alpha1-antitrypsin
- portland
-
endoproteolysis
- diagnostics
- kexin
-
kexin-like
- ski-1
-
cys-rich
- medicine
-
subtilisin-related
Reaction
releases mature proteins from their proproteins by cleavage of Arg-Xaa-Yaa-Arg-Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys =
Synonyms
PACE 4, PACE-4, PACE4, PACE4/SPC4, paired basic amino acid cleaving enzyme 4, paired basic amino acid-cleaving enzyme 4, paired basic amino-acid-cleaving enzyme-4, PC7, proprotein convertase PACE4, S08.075, SPC4, subtilisin-like proprotein convertase, subtilisin-like proprotein convertase 4, subtilisin-like proprotein convertase PACE4, XPACE4
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Reference on EC 3.4.21.B25 - PACE4 proprotein convertase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Taniguchi, T.; Kuroda, R.; Sakurai, K.; Nagahama, M.; Wada, I.; Tsuji, A.; Matsuda, Y.
A critical role for the carboxy terminal region of the proprotein convertase, PACE4A, in the regulation of its autocatalytic activation coupled with secretion
Biochem. Biophys. Res. Commun.
290
878-884
2002
Homo sapiens
Mains, R.E.; Berard, C.A.; Denault, J.B.; Zhou, A.; Johnson, R.C.; Leduc, R.
PACE4: a subtilisin-like endoprotease with unique properties
Biochem. J.
321
587-593
1997
Rattus norvegicus
-
Sucic, J.F.; Moehring, J.M.; Inocencio, N.M.; Luchini, J.W.; Moehring, T.J.
Endoprotease PACE4 is Ca2+-dependent and temperature-sensitive and can partly rescue the phenotype of a furin-deficient cell strain
Biochem. J.
339
639-647
1999
Homo sapiens
Rehemtulla, A.; Barr, P.J.; Rhodes, C.J.; Kaufman, R.J.
PACE4 is a member of the mammalian propeptidase family that has overlapping but not identical substrate specificity to PACE
Biochemistry
32
11586-11590
1993
Homo sapiens
Tsuji, A.; Sakurai, K.; Kiyokage, E.; Yamazaki, T.; Koide, S.; Toida, K.; Ishimura, K.; Matsuda, Y.
Secretory proprotein convertases PACE4 and PC6A are heparin-binding proteins which are localized in the extracellular matrix. Potential role of PACE4 in the activation of proproteins in the extracellular matrix
Biochim. Biophys. Acta
1645
95-104
2003
Homo sapiens
Johnson, R.C.; Darlington, D.N.; Hand, T.A.; Bloomquist, B.T.; Mains, R.E.
PACE4: a subtilisin-like endoprotease prevalent in the anterior pituitary and regulated by thyroid status
Endocrinology
135
1178-1185
1994
Rattus norvegicus (Q63415), Rattus norvegicus
Pinnix, I.; Council, J.E.; Roseberry, B.; Onstead, L.; Mallender, W.; Sucic, J.; Sambamurti, K.
Convertases other than furin cleave beta-secretase to its mature form
FASEB J.
15
1810-1812
2001
Homo sapiens
Creemers, J.W.; Groot Kormelink, P.J.; Roebroek, A.J.; Nakayama, K.; Van de Ven, W.J.
Proprotein processing activity and cleavage site selectivity of the Kex2-like endoprotease PACE4
FEBS Lett.
336
65-69
1993
Homo sapiens
Brakch, N.; Galanopoulou, A.S.; Patel, Y.C.; Boileau, G.; Seidah, N.G.
Comparative proteolytic processing of rat prosomatostatin by the convertases PC1, PC2, furin, PACE4 and PC5 in constitutive and regulated secretory pathways
FEBS Lett.
362
143-146
1995
Mammalia
Zhong, M.; Benjannet, S.; Lazure, C.; Munzer, S.; Seidah, N.G.
Functional analysis of human PACE4-A and PACE4-C isoforms: identification of a new PACE4-CS isoform
FEBS Lett.
396
31-36
1996
Homo sapiens
Nagahama, M.; Taniguchi, T.; Hashimoto, E.; Imamaki, A.; Mori, K.; Tsuji, A.; Matsuda, Y.
Biosynthetic processing and quaternary interactions of proprotein convertase SPC4 (PACE4)
FEBS Lett.
434
155-159
1998
Homo sapiens
Gordon, V.M.; Rehemtulla, A.; Leppla, S.H.
A role for PACE4 in the proteolytic activation of anthrax toxin protective antigen
Infect. Immun.
65
3370-3375
1997
Mammalia
Mori, K.; Kii, S.; Tsuji, A.; Nagahama, M.; Imamaki, A.; Hayashi, K.; Akamatsu, T.; Nagamune, H.; Matsuda, Y.
A novel human PACE4 isoform, PACE4E is an active processing protease containing a hydrophobic cluster at the carboxy terminus
J. Biochem.
121
941-948
1997
Homo sapiens (P29122), Homo sapiens
Mori, K.; Imamaki, A.; Nagata, K.; Yonetomi, Y.; Kiyokage-Yoshimoto, R.; Martin, T.J.; Gillespie, M.T.; Nagahama, M.; Tsuji, A.; Matsuda, Y.
Subtilisin-like proprotein convertases, PACE4 and PC8, as well as furin, are endogenous proalbumin convertases in HepG2 cells
J. Biochem.
125
627-633
1999
Homo sapiens
Tsuji, A.; Ikoma, T.; Hashimoto, E.; Matsuda, Y.
Development of selectivity of alpha1-antitrypsin variant by mutagenesis in its reactive site loop against proprotein convertase. A crucial role of the P4 arginine in PACE4 inhibition
Protein Eng.
15
123-130
2002
Homo sapiens
Tsuji, A.; Kikuchi, Y.; Sato, Y.; Koide, S.; Yuasa, K.; Nagahama, M.; Matsuda, Y.
A proteomic approach reveals transient association of reticulocalbin-3, a novel member of the CREC family, with the precursor of subtilisin-like proprotein convertase, PACE4
Biochem. J.
396
51-59
2006
Homo sapiens
Bassi, D.E.; Lopez De Cicco, R.; Cenna, J.; Litwin, S.; Cukierman, E.; Klein-Szanto, A.J.
PACE4 expression in mouse basal keratinocytes results in basement membrane disruption and acceleration of tumor progression
Cancer Res.
65
7310-7319
2005
Rattus norvegicus
Birsoy, B.; Berg, L.; Williams, P.H.; Smith, J.C.; Wylie, C.C.; Christian, J.L.; Heasman, J.
XPACE4 is a localized pro-protein convertase required for mesoderm induction and the cleavage of specific TGFb proteins in Xenopus development
Development
132
591-602
2005
Xenopus laevis (Q5G5T8), Xenopus laevis (Q5G5T9)
Mains, R.E.
Proprotein convertase PACE4
Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , Eds. ) Academic Press
2
1871-1874
2004
Aplysia sp., Mus musculus, Homo sapiens (P29122), Rattus norvegicus (Q63415)
-
Nour, N.; Mayer, G.; Mort, J.S.; Salvas, A.; Mbikay, M.; Morrison, C.J.; Overall, C.M.; Seidah, N.G.
The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases
Mol. Biol. Cell
16
5215-5226
2005
Mus musculus
Lapierre, M.; Siegfried, G.; Scamuffa, N.; Bontemps, Y.; Calvo, F.; Seidah, N.G.; Khatib, A.M.
Opposing function of the proprotein convertases furin and PACE4 on breast cancer cells malignant phenotypes: role of tissue inhibitors of metalloproteinase-1
Cancer Res.
67
9030-9034
2007
Homo sapiens
Page, R.E.; Klein-Szanto, A.J.; Litwin, S.; Nicolas, E.; Al-Jumaily, R.; Alexander, P.; Godwin, A.K.; Ross, E.A.; Schilder, R.J.; Bassi, D.E.
Increased expression of the pro-protein convertase furin predicts decreased survival in ovarian cancer
Cell. Oncol.
29
289-299
2007
Homo sapiens
Akamatsu, T.; Purwanti, N.; Karabasil, M.R.; Li, X.; Yao, C.; Kanamori, N.; Hosoi, K.
Temporospatially regulated expression of subtilisin-like proprotein convertase PACE4 (SPC4) during development of the rat submandibular gland
Dev. Dyn.
236
314-320
2007
Rattus norvegicus (Q63415)
Yuasa, K.; Suzue, K.; Nagahama, M.; Matsuda, Y.; Tsuji, A.
Transcriptional regulation of subtilisin-like proprotein convertase PACE4 by E2F: possible role of E2F-mediated upregulation of PACE4 in tumor progression
Gene
402
103-110
2007
Homo sapiens
Seidah, N.G.; Mayer, G.; Zaid, A.; Rousselet, E.; Nassoury, N.; Poirier, S.; Essalmani, R.; Prat, A.
The activation and physiological functions of the proprotein convertases
Int. J. Biochem. Cell Biol.
40
1111-1125
2008
Homo sapiens
Tsuji, A.; Kanie, H.; Makise, H.; Yuasa, K.; Nagahama, M.; Matsuda, Y.
Engineering of alpha 1-antitrypsin variants selective for subtilisin-like proprotein convertases PACE4 and PC6: importance of the P2 residue in stable complex formation of the serpin with proprotein convertase
Protein Eng. Des. Sel.
20
163-170
2007
Homo sapiens
Freyer, C.; Kilpatrick, L.M.; Salamonsen, L.A.; Nie, G.
Pro-protein convertases (PCs) other than PC6 are not tightly regulated for implantation in the human endometrium
Reproduction
133
1189-1197
2007
Homo sapiens (P29122), Homo sapiens
Malfait, A.M.; Arner, E.C.; Song, R.H.; Alston, J.T.; Markosyan, S.; Staten, N.; Yang, Z.; Griggs, D.W.; Tortorella, M.D.
Proprotein convertase activation of aggrecanases in cartilage in situ
Arch. Biochem. Biophys.
478
43-51
2008
Rattus norvegicus (Q78EH2)
Padua, M.B.; Hansen, P.J.
Regulation of DNA synthesis and the cell cycle in human prostate cancer cells and lymphocytes by ovine uterine serpin
BMC Cell Biol.
9
5
2008
Mus musculus (P29121)
Akamatsu, T.; Azlina, A.; Purwanti, N.; Karabasil, M.R.; Hasegawa, T.; Yao, C.; Hosoi, K.
Inhibition and transcriptional silencing of a subtilisin-like proprotein convertase, PACE4/SPC4, reduces the branching morphogenesis of and AQP5 expression in rat embryonic submandibular gland
Dev. Biol.
325
434-443
2009
Rattus norvegicus (Q78EH2)
Remacle, A.G.; Shiryaev, S.A.; Oh, E.S.; Cieplak, P.; Srinivasan, A.; Wei, G.; Liddington, R.C.; Ratnikov, B.I.; Parent, A.; Desjardins, R.; Day, R.; Smith, J.W.; Lebl, M.; Strongin, A.Y.
Substrate cleavage analysis of furin and related proprotein convertases. A comparative study
J. Biol. Chem.
283
20897-20906
2008
Homo sapiens (P29122), Homo sapiens
Komiyama, T.; Coppola, J.M.; Larsen, M.J.; van Dort, M.E.; Ross, B.D.; Day, R.; Rehemtulla, A.; Fuller, R.S.
Inhibition of furin/PC-catalyzed surface and intracellular processing by small molecules
J. Biol. Chem.
284
15729-15738
2009
Rattus norvegicus (Q78EH2)
Xiao, Y.; Chen, G.; Richard, J.; Rougeau, N.; Li, H.; Seidah, N.G.; Cohen, E.A.
Cell-surface processing of extracellular human immunodeficiency virus type 1 Vpr by proprotein convertases
Virology
372
384-397
2008
Homo sapiens (Q6UW60), Homo sapiens
Fuller, J.A.; Brun-Zinkernagel, A.M.; Clark, A.F.; Wordinger, R.J.
Subtilisin-like proprotein convertase expression, localization, and activation in the human retina and optic nerve head
Invest. Ophthalmol. Vis. Sci.
50
5759-5768
2009
Homo sapiens
Byun, S.; Tortorella, M.D.; Malfait, A.M.; Fok, K.; Frank, E.H.; Grodzinsky, A.J.
Transport and equilibrium uptake of a peptide inhibitor of PACE4 into articular cartilage is dominated by electrostatic interactions
Arch. Biochem. Biophys.
499
32-39
2010
Rattus norvegicus
Yuasa, K.; Masuda, T.; Yoshikawa, C.; Nagahama, M.; Matsuda, Y.; Tsuji, A.
Subtilisin-like proprotein convertase PACE4 is required for skeletal muscle differentiation
J. Biochem.
146
407-415
2009
Mus musculus
Akamatsu, T.; Azlina, A.; Javkhlan, P.; Hasegawa, T.; Yao, C.; Hosoi, K.
Salivary gland development: its mediation by a subtilisin-like proprotein convertase, PACE4
J. Med. Invest.
56
241-246
2009
Rattus norvegicus
Mesnard, D.; Donnison, M.; Fuerer, C.; Pfeffer, P.L.; Constam, D.B.
The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities
Genes Dev.
25
1871-1880
2011
Mus musculus
Akamatsu, T.
Physiological role of a subtilisin - Like proprotein convertase, PACE4, in submandibular gland development
J. Oral Biosci.
52
81-93
2010
Rattus norvegicus
-
Yuasa, K.; Futamatsu, G.; Kawano, T.; Muroshita, M.; Kageyama, Y.; Taichi, H.; Ishikawa, H.; Nagahama, M.; Matsuda, Y.; Tsuji, A.
Subtilisin-like proprotein convertase paired basic amino acid-cleaving enzyme 4 is required for chondrogenic differentiation in ATDC5 cells
FEBS J.
279
3997-4009
2012
Mus musculus
Kara, I.; Poggi, M.; Bonardo, B.; Govers, R.; Landrier, J.F.; Tian, S.; Leibiger, I.; Day, R.; Creemers, J.W.; Peiretti, F.
The paired basic amino acid-cleaving enzyme 4 (PACE4) is involved in the maturation of insulin receptor isoform B: an opportunity to reduce the specific insulin receptor-dependent effects of insulin-like growth factor 2 (IGF2)
J. Biol. Chem.
290
2812-2821
2015
Homo sapiens (P29122)
Kim, H.; Tabata, A.; Tomoyasu, T.; Ueno, T.; Uchiyama, S.; Yuasa, K.; Tsuji, A.; Nagamune, H.
Estrogen stimuli promote osteoblastic differentiation via the subtilisin-like proprotein convertase PACE4 in MC3T3-E1 cells
J. Bone Miner. Metab.
33
30-39
2015
Mus musculus
Kwiatkowska, A.; Couture, F.; Levesque, C.; Ly, K.; Beauchemin, S.; Desjardins, R.; Neugebauer, W.; Dory, Y.L.; Day, R.
Novel insights into structure-activity relationships of N-terminally modified PACE4 inhibitors
ChemMedChem
11
289-301
2016
Homo sapiens (P29122)
Dianati, V.; Shamloo, A.; Kwiatkowska, A.; Desjardins, R.; Soldera, A.; Day, R.; Dory, Y.L.
Rational design of a highly potent and selective peptide inhibitor of PACE4 by salt bridge interaction with D160 at position P3
ChemMedChem
12
1169-1172
2017
Homo sapiens (P29122)
Yao, Z.; Sun, B.; Hong, Q.; Yan, J.; Mu, D.; Li, J.; Sheng, H.; Guo, H.
PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways
Drug Des. Devel. Ther.
9
5911-5923
2015
Homo sapiens (P29122), Homo sapiens
Bessonnard, S.; Mesnard, D.; Constam, D.
PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation
J. Cell Biol.
210
1185-1197
2015
Mus musculus
Lin, Y.E.; Wu, Q.N.; Lin, X.D.; Li, G.Q.; Zhang, Y.J.
Expression of paired basic amino acid-cleaving enzyme 4 (PACE4) correlated with prognosis in non-small cell lung cancer (NSCLC) patients
J. Thorac. Dis.
7
850-860
2015
Homo sapiens (P29122), Homo sapiens
Wang, F.; Wang, L.; Pan, J.
PACE4 regulates proliferation, migration and invasion in human breast cancer MDA-MB-231 cells
Mol. Med. Rep.
11
698-704
2015
Homo sapiens (P29122), Homo sapiens
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