3.4.21.B25: PACE4 proprotein convertase

This is an abbreviated version!
For detailed information about PACE4 proprotein convertase, go to the full flat file.

Reaction

releases mature proteins from their proproteins by cleavage of Arg-Xaa-Yaa-Arg-Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys =

Synonyms

PACE 4, PACE-4, PACE4, PACE4/SPC4, paired basic amino acid cleaving enzyme 4, paired basic amino acid-cleaving enzyme 4, paired basic amino-acid-cleaving enzyme-4, PC7, proprotein convertase PACE4, S08.075, SPC4, subtilisin-like proprotein convertase, subtilisin-like proprotein convertase 4, subtilisin-like proprotein convertase PACE4, XPACE4

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.B25 PACE4 proprotein convertase

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Results	in table
4	Activating Compound
7	AA Sequence
13	Application
1	CAS Registry Number
24	Cloned(Commentary)
425	Disease/ Diagnostics
7	Expression
19	General Information
30	IC50 Value
78	Inhibitors
46	Ki Value [mM]
2	KM Value [mM]
7	Localization
2	Metals/Ions
18	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
53	Organism
1	pH Optimum
5	Posttranslational Modification
7	Protein Variants
1	Reaction
30	Reaction Type
52	Reference
75	Source Tissue
53	Substrates and Products (Substrate)
2	Subunits
70	Synonyms
1	Temperature Optimum [°C]
1	Temperature Range [°C]

Natural Substrates Products

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Natural Substrates Products on EC 3.4.21.B25 - PACE4 proprotein convertase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

CLIP protein + H2O

?

Mus musculus

-

-

717637

-

-

?

human immunodeficiency virus type 1 Vpr + H2O

?

Homo sapiens

Q6UW60

undergoes proteolytic processing at a very well conserved proprotein convertase cleavage site, R85QRR88-/-, proprotein convertases PC5 and PACE4 can efficiently process extracellular Vpr

695251

-

-

?

insulin receptor isoform B zymogen + H2O

mature insulin receptor isoform B + ?

Homo sapiens

P29122

maturation

732179

-

-

?

preprohepcidin + H2O

?

Mus musculus

P29121

key role of the convertases furin, PACE4, PC5 and/or PC7 in the generation and secretion of active hepcidin

691487

-

-

?

pro-branching morphogenesis protein 2 + H2O

?

Rattus norvegicus

-

-

718024

-

-

?

pro-complement C3 + H2O

?

Homo sapiens

-

-

653709

-

653709

?

pro-Nodal + H2O

?

Mus musculus

-

-

717637

-

-

?

proform bone morphogenetic protein 6 + H2O

mature bone morphogenetic protein 6 + ?

Mus musculus

-

BMP6, the substrate is exclusively found in hypertrophic chondrocytes

731787

-

-

?

additional information

?

-

3 entries

additional information

?

-

Homo sapiens

-

enzyme binds tightly to heparin and anchors heparan sulfate proteoglycans at the extracellular matrix, role in spatiotemporal regulation of TGFbeta-related factors' biological activity

650402

-

650402

?

additional information

?

-

Mammalia

-

role in proteolytic activation of anthrax toxin PA

651474

-

651474

?

additional information

?

-

Rattus norvegicus

Q78EH2

PACE4 is identified as a proprotein convertase responsible for activation of aggrecanases in osteoarthritic and cytokine-stimulated cartilage

690625

-

-

?