3.4.21.B25: PACE4 proprotein convertase

This is an abbreviated version!
For detailed information about PACE4 proprotein convertase, go to the full flat file.

Word Map on EC 3.4.21.B25

3.4.21.B25

convertases

furin

prohormone

endoproteases

furin-deficient

furin-like

alpha1-pdx

dibasic

pro-proteins

alpha1-antitrypsin

portland

endoproteolysis

diagnostics

kexin

kexin-like

ski-1

cys-rich

medicine

subtilisin-related

Reaction

releases mature proteins from their proproteins by cleavage of Arg-Xaa-Yaa-Arg-Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys =

Synonyms

PACE 4, PACE-4, PACE4, PACE4/SPC4, paired basic amino acid cleaving enzyme 4, paired basic amino acid-cleaving enzyme 4, paired basic amino-acid-cleaving enzyme-4, PC7, proprotein convertase PACE4, S08.075, SPC4, subtilisin-like proprotein convertase, subtilisin-like proprotein convertase 4, subtilisin-like proprotein convertase PACE4, XPACE4

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.B25 PACE4 proprotein convertase

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Results	in table
4	Activating Compound
7	AA Sequence
13	Application
1	CAS Registry Number
24	Cloned(Commentary)
425	Disease/ Diagnostics
7	Expression
19	General Information
30	IC50 Value
78	Inhibitors
46	Ki Value [mM]
2	KM Value [mM]
7	Localization
2	Metals/Ions
18	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
53	Organism
1	pH Optimum
5	Posttranslational Modification
7	Protein Variants
1	Reaction
30	Reaction Type
52	Reference
75	Source Tissue
53	Substrates and Products (Substrate)
2	Subunits
70	Synonyms
1	Temperature Optimum [°C]
1	Temperature Range [°C]

Localization

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Localization on EC 3.4.21.B25 - PACE4 proprotein convertase

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the enzyme is constitutively secreted into the extracellular media and localizes at the cell surface and in the extracellular matrix

in stage 1 oocytes, XPACE4 localizes to the mitochondrial cloud, at stage 2, the mitochondrial cloud disperses, then XPACE4 mRNA co-localizes with the vegetal cortex where it remains for the rest of oogenesis

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