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3.4.21.25: cucumisin

This is an abbreviated version!
For detailed information about cucumisin, go to the full flat file.

Word Map on EC 3.4.21.25

Reaction

hydrolysis of proteins with broad specificity =

Synonyms

Cuc m 1, cucumisin, cucumisin homologue, More, protC1, protease C1, religiosin C, soybean protease C1

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.25 cucumisin

Inhibitors

Inhibitors on EC 3.4.21.25 - cucumisin

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4-(2-aminoethyl)-benzenesulfonyl fluoride
-
17% inhibition by 1 mM; i.e. Pefabloc SC
5,5'-dithiobis(2-nitrobenzoic acid)
-
11% inhibition by 1 mM
acetonitrile
-
60.03% residual activity at 50% (v/v)
alpha2-Macroglobulin
-
38% inhibition by a concentration of 0.001 mM with casein as substrate, and 18% inhibition with succinyl-Ala-Pro-Ala-p-nitroanilide as substrate
-
ARA12 propeptide
-
-
-
butanol
-
68.24% residual activity at 50% (v/v)
Cd2+
-
about 8% residual activity at 5 mM
chymostatin
-
2.45% residual activity at 5 mM
Co2+
-
about 15% residual activity at 5 mM
cucumisin propeptide
-
potent inhibitor of its mature enzyme, competitive inhibition
-
diisopropyl fluorophosphate
diisopropylfluorophosphate
-
2.34% residual activity at 1 mM
dioxane
-
65.35% residual activity at 50% (v/v)
EDTA
-
68% residual activity at 2 mM
EGTA
-
72% residual activity at 2 mM
ethanol
-
75.09% residual activity at 50% (v/v)
Fe2+
-
about 55% residual activity at 5 mM
HgCl2
phenylmethylsulfonyl fluoride
Phenylmethylsulfonylfluoride
-
strong inhibition
propeptide
77.7% inhibition at 200 mM
-
RSP1 propeptide
-
-
-
Zn2+
-
about 10% residual activity at 5 mM
ZnCl2
-
11% inhibition by 2 mM
additional information
-