3.4.21.22: coagulation factor IXa
This is an abbreviated version!
For detailed information about coagulation factor IXa, go to the full flat file.
Word Map on EC 3.4.21.22
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3.4.21.22
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hemophilia
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bleeding
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clot
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prothrombin
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thrombin
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thromboplastin
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anticoagulant
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platelet
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thrombosis
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antithrombin
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viiia
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x-linked
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heparin
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adeno-associated
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fibrinogen
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plasma-derived
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willebrand
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prophylaxis
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k-dependent
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infusions
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prophylactic
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hemostatic
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zymogen
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procoagulant
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haemostasis
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fixa
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thrombogenicity
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gamma-carboxyglutamic
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one-stage
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coagulopathy
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thromboembolic
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anti-factor
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amidolytic
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on-demand
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high-purity
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fibrinopeptide
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d-dimer
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thrombin-antithrombin
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exosite
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arthropathy
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prekallikrein
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cryoprecipitate
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medicine
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gamma-carboxylation
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rfviia
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bethesda
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alloantibodies
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prothrombinase
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thrombin-activated
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diathesis
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novoseven
- 3.4.21.22
- hemophilia
- bleeding
- clot
- prothrombin
- thrombin
- thromboplastin
-
anticoagulant
- platelet
- thrombosis
- antithrombin
- viiia
-
x-linked
- heparin
-
adeno-associated
- fibrinogen
-
plasma-derived
- willebrand
-
prophylaxis
-
k-dependent
-
infusions
-
prophylactic
-
hemostatic
- zymogen
-
procoagulant
-
haemostasis
- fixa
-
thrombogenicity
-
gamma-carboxyglutamic
-
one-stage
- coagulopathy
-
thromboembolic
-
anti-factor
-
amidolytic
-
on-demand
-
high-purity
-
fibrinopeptide
-
d-dimer
-
thrombin-antithrombin
-
exosite
- arthropathy
- prekallikrein
-
cryoprecipitate
- medicine
-
gamma-carboxylation
- rfviia
-
bethesda
-
alloantibodies
- prothrombinase
-
thrombin-activated
- diathesis
- novoseven
Reaction
Selective cleavage of Arg-/-Ile bond in factor X to form factor Xa =
Synonyms
activated Christmas factor, activated coagulation factor IX, activated factor IX, activated FIX, blood coagulation factor IXa, Christmas factor, circulating factor IXa, coagulation factor IX, coagulation factor IXa, factor IX, factor IXa, factor IXaAL, factor IXaalpha, factor IXabeta, factor IXabeta', factor IXaCH, factor IXalphabeta, factor IXaN, factor XIa, FIX, FIXa, FIXC, Gla-domainless factor IXabeta', human coagulation factor IXa, intrinsic Xase, More
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Metals Ions
Metals Ions on EC 3.4.21.22 - coagulation factor IXa
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Ca2+
Mg2+
Na+
Ca2+
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factor IX activation is the first calcium-dependent reaction in intrinsic system clotting
Ca2+
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5 mM, optimal concentration for cleavage of factor X by factor IXa on phospholipid membranes
Ca2+
for proper binding of factor IXa to phospholipid and factor VIIIa, all of the Ca2+-sites in factor IXa must be filled
Ca2+
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binding of a subpopulation of platelets to the enzyme is activated by the protease-activated receptor-1, PAR-1, requirring both release of calcium from internal stores and influx of extracellular calcium, overview
Ca2+
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the reaction is performed by the intrinsic FX-activating complex consisting of FIXa and FVIIIa on a negatively charged phospholipid surface in presence of Ca2+
Ca2+
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inhibition of activation of aFIX to FIXa when lowering concentration from 1.0 to 0.5 mM
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1.0 mM, highest aFIX concentration of 1.36 IU/ml in combination with 1.0 mM Ca2+
Mg2+
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factor IX-binding protein binds factor IXa with high binding-affinity in a Mg2+-dependent manner
Na+
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activates the amidolytic activity of the enzyme, but does only marginally influence the proteolytic activity of factor IXa in the prothrombinase complex, not required for activation of factor X
Na+
no requirement for Na+ in presence of Ca2+, can partially substite for Ca2+