3.4.21.22: coagulation factor IXa
This is an abbreviated version!
For detailed information about coagulation factor IXa, go to the full flat file.
Word Map on EC 3.4.21.22
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3.4.21.22
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hemophilia
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bleeding
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clot
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prothrombin
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thrombin
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thromboplastin
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anticoagulant
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platelet
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thrombosis
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antithrombin
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viiia
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x-linked
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heparin
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adeno-associated
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fibrinogen
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plasma-derived
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willebrand
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prophylaxis
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k-dependent
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infusions
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prophylactic
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hemostatic
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zymogen
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procoagulant
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haemostasis
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fixa
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thrombogenicity
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gamma-carboxyglutamic
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one-stage
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coagulopathy
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thromboembolic
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anti-factor
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amidolytic
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on-demand
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high-purity
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fibrinopeptide
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d-dimer
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thrombin-antithrombin
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exosite
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arthropathy
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prekallikrein
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cryoprecipitate
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medicine
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gamma-carboxylation
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rfviia
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bethesda
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alloantibodies
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prothrombinase
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thrombin-activated
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diathesis
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novoseven
- 3.4.21.22
- hemophilia
- bleeding
- clot
- prothrombin
- thrombin
- thromboplastin
-
anticoagulant
- platelet
- thrombosis
- antithrombin
- viiia
-
x-linked
- heparin
-
adeno-associated
- fibrinogen
-
plasma-derived
- willebrand
-
prophylaxis
-
k-dependent
-
infusions
-
prophylactic
-
hemostatic
- zymogen
-
procoagulant
-
haemostasis
- fixa
-
thrombogenicity
-
gamma-carboxyglutamic
-
one-stage
- coagulopathy
-
thromboembolic
-
anti-factor
-
amidolytic
-
on-demand
-
high-purity
-
fibrinopeptide
-
d-dimer
-
thrombin-antithrombin
-
exosite
- arthropathy
- prekallikrein
-
cryoprecipitate
- medicine
-
gamma-carboxylation
- rfviia
-
bethesda
-
alloantibodies
- prothrombinase
-
thrombin-activated
- diathesis
- novoseven
Reaction
Selective cleavage of Arg-/-Ile bond in factor X to form factor Xa =
Synonyms
activated Christmas factor, activated coagulation factor IX, activated factor IX, activated FIX, blood coagulation factor IXa, Christmas factor, circulating factor IXa, coagulation factor IX, coagulation factor IXa, factor IX, factor IXa, factor IXaAL, factor IXaalpha, factor IXabeta, factor IXabeta', factor IXaCH, factor IXalphabeta, factor IXaN, factor XIa, FIX, FIXa, FIXC, Gla-domainless factor IXabeta', human coagulation factor IXa, intrinsic Xase, More
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KCat KM Value
KCat KM Value on EC 3.4.21.22 - coagulation factor IXa
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1.5
Factor X
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mutant Y94F/A95aK/K98T/Y177F/I213V/E219G, FX activation in presence of FVIIIa
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2.825
Factor X
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wild type enzyme, in the absence of factor VIIIa, at pH 7.4 and 37°C
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4.163
Factor X
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mutant enzyme E410H, in the absence of factor VIIIa, at pH 7.4 and 37°C
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4.326
Factor X
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mutant enzyme E410N, in the absence of factor VIIIa, at pH 7.4 and 37°C
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4.374
Factor X
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mutant enzyme E410L, in the absence of factor VIIIa, at pH 7.4 and 37°C
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4.693
Factor X
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mutant enzyme E410A, in the absence of factor VIIIa, at pH 7.4 and 37°C
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5.33
Factor X
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mutant Y94F/K98T/Y177F/I213V/E219, FX activation in presence of FVIIIa
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18.17
Factor X
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mutant Y94F/A95aK/K98T/Y177F/I213V/E219G, FX activation in absence of FVIIIa
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55
Factor X
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mutant Y94F/K98T/Y177F/I213V/E219, FX activation in absence of FVIIIa
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25000
Factor X
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FIXa/FXa chimera in which the 39-loop of the protease is replaced with the corresponding loop of FXa, in TBS containing 0.1 mg/ml bovine serum albumin, 0.1% polyethylene glycol (PEG) 8000, and 5 mM Ca2+, at 22°C, pH not specified in the publication
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42800
Factor X
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mutant enzyme E410N, in the presence of factor VIIIa, at pH 7.4 and 37°C
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49000
Factor X
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wild type enzyme, in TBS containing 0.1 mg/ml bovine serum albumin, 0.1% polyethylene glycol (PEG) 8000, and 5 mM Ca2+, at 22°C, pH not specified in the publication
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49800
Factor X
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mutant enzyme E410A, in the presence of factor VIIIa, at pH 7.4 and 37°C
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51600
Factor X
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mutant enzyme E410L, in the presence of factor VIIIa, at pH 7.4 and 37°C
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52900
Factor X
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mutant enzyme E410H, in the presence of factor VIIIa, at pH 7.4 and 37°C
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54500
Factor X
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wild type enzyme, in the presence of factor VIIIa, at pH 7.4 and 37°C
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9.3
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wild type enzyme, in 0.02 M Tris-HCl (pH 7.5) buffer containing 0.1 M NaCl, 0.1 mg/ml bovine serum albumin, 33% ethylene glycol, and 5 mM Ca2+, at 22°C
14.6
L-Leu-Gly-L-Arg-4-nitroanilide
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FIXa/FXa chimera in which the 39-loop of the protease is replaced with the corresponding loop of FXa, in 0.02 M Tris-HCl (pH 7.5) buffer containing 0.1 M NaCl, 0.1 mg/ml bovine serum albumin, 33% ethylene glycol, and 5 mM Ca2+, at 22°C