3.4.21.22: coagulation factor IXa
This is an abbreviated version!
For detailed information about coagulation factor IXa, go to the full flat file.
Word Map on EC 3.4.21.22
-
3.4.21.22
-
hemophilia
-
bleeding
-
clot
-
prothrombin
-
thrombin
-
thromboplastin
-
anticoagulant
-
platelet
-
thrombosis
-
antithrombin
-
viiia
-
x-linked
-
heparin
-
adeno-associated
-
fibrinogen
-
plasma-derived
-
willebrand
-
prophylaxis
-
k-dependent
-
infusions
-
prophylactic
-
hemostatic
-
zymogen
-
procoagulant
-
haemostasis
-
fixa
-
thrombogenicity
-
gamma-carboxyglutamic
-
one-stage
-
coagulopathy
-
thromboembolic
-
anti-factor
-
amidolytic
-
on-demand
-
high-purity
-
fibrinopeptide
-
d-dimer
-
thrombin-antithrombin
-
exosite
-
arthropathy
-
prekallikrein
-
cryoprecipitate
-
medicine
-
gamma-carboxylation
-
rfviia
-
bethesda
-
alloantibodies
-
prothrombinase
-
thrombin-activated
-
diathesis
-
novoseven
- 3.4.21.22
- hemophilia
- bleeding
- clot
- prothrombin
- thrombin
- thromboplastin
-
anticoagulant
- platelet
- thrombosis
- antithrombin
- viiia
-
x-linked
- heparin
-
adeno-associated
- fibrinogen
-
plasma-derived
- willebrand
-
prophylaxis
-
k-dependent
-
infusions
-
prophylactic
-
hemostatic
- zymogen
-
procoagulant
-
haemostasis
- fixa
-
thrombogenicity
-
gamma-carboxyglutamic
-
one-stage
- coagulopathy
-
thromboembolic
-
anti-factor
-
amidolytic
-
on-demand
-
high-purity
-
fibrinopeptide
-
d-dimer
-
thrombin-antithrombin
-
exosite
- arthropathy
- prekallikrein
-
cryoprecipitate
- medicine
-
gamma-carboxylation
- rfviia
-
bethesda
-
alloantibodies
- prothrombinase
-
thrombin-activated
- diathesis
- novoseven
Reaction
Selective cleavage of Arg-/-Ile bond in factor X to form factor Xa =
Synonyms
activated Christmas factor, activated coagulation factor IX, activated factor IX, activated FIX, blood coagulation factor IXa, Christmas factor, circulating factor IXa, coagulation factor IX, coagulation factor IXa, factor IX, factor IXa, factor IXaAL, factor IXaalpha, factor IXabeta, factor IXabeta', factor IXaCH, factor IXalphabeta, factor IXaN, factor XIa, FIX, FIXa, FIXC, Gla-domainless factor IXabeta', human coagulation factor IXa, intrinsic Xase, More
ECTree
Advanced search results
Natural Substrates Products
Natural Substrates Products on EC 3.4.21.22 - coagulation factor IXa
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REACTION DIAGRAM
methylsulfonyl-D-cyclohexylglycyl-Arg-7-amido-4-methylcoumarin + H2O
methylsulfonyl-D-cyclohexylglycyl-Arg + 7-amino-4-methylcoumarin
-
assay at 37°C
-
-
?
?
-
gamma-carboxyglutamic acid, Gla-domains of vitamin K-dependent coagulation factors are essential for binding of phospholipid and for the activation raections such as factor X, the interaction of the Gla-domain with metal ions like Ca2+ is essential for its function
-
-
?
factor X + H2O
?
-
a chymotrypsin homologue, and one of the gamma-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor IX is activated by factor XIa
-
-
?
factor X + H2O
?
-
a chymotrypsin homologue, and one of the gamma-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor IX is activated by factor XIa
-
-
?
factor X + H2O
activated factor X + ?
factor IXa is a vitamin K-dependent blood coagulation factor that is essential for the amplification or consolidation phase of blood coagulation
-
-
?
factor X + H2O
activated factor X + ?
-
proteolytic activity, factor IXa acts as part of phosphocholine/phosphoserine vesicles interacting with factor VIIIa in the complex in a sodium-dependent manner, overview
-
-
?
factor X + H2O
activated factor X + ?
-
the enzyme acts in complex with factor VIIIa, FVIIIa deficiency causes the bleeding disorder hemaphilia A
-
-
?
factor X + H2O
activated factor X + ?
-
the enzyme is part of the coagulation cascade, factor X activation by the intrinsic tenase complex, factor IXa-factor VIIIa, is the rate-limiting step for thrombin generation
-
-
?
factor X + H2O
factor Xa
in the presence of FVIIIa (5 units/ml) at 37 °C
-
-
?
Factor X + H2O
Factor Xa + ?
-
-
-
-
?
Factor X + H2O
Factor Xa + ?
-
the activation of factor X by factor IXa-factor VIIIa complex, known as the intrinsic tenase complex, results in the loss of a 55-residue activation peptide and subsequent formation of activated factor X
-
-
?
?
-
the enzyme is a trypsin-like serine protease in plasma that binds to its cofactor factor VIIIa on negatively charged membrane surfaces in the presence of Ca2+, i.e. intrinsic Xase, to activate factor X to factor Xa in the clotting cascade, factor IXa plays an essential role in hemostasis and its deficiency is associated with the life threatening disease, hemophilia B
-
-
?
additional information
?
-
human recombinant factor IX has blood clotting activity
-
-
?
additional information
?
-
-
human recombinant factor IX has blood clotting activity
-
-
?