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3.4.21.22: coagulation factor IXa

This is an abbreviated version!
For detailed information about coagulation factor IXa, go to the full flat file.

Word Map on EC 3.4.21.22

Reaction

Selective cleavage of Arg-/-Ile bond in factor X to form factor Xa =

Synonyms

activated Christmas factor, activated coagulation factor IX, activated factor IX, activated FIX, blood coagulation factor IXa, Christmas factor, circulating factor IXa, coagulation factor IX, coagulation factor IXa, factor IX, factor IXa, factor IXaAL, factor IXaalpha, factor IXabeta, factor IXabeta', factor IXaCH, factor IXalphabeta, factor IXaN, factor XIa, FIX, FIXa, FIXC, Gla-domainless factor IXabeta', human coagulation factor IXa, intrinsic Xase, More

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.22 coagulation factor IXa

Crystallization

Crystallization on EC 3.4.21.22 - coagulation factor IXa

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
activated mutant K98T, sitting drop vapor diffusion method, using 0.1 M MES (pH 6.5) and 18-24% (w/v) PEG6000
hanging drop vapor diffusion method, using 0.25 M ammonium acetate, 19.5% (w/v) PEG 3350
of a recombinant two-domain construct of fIXa in complex with p-benzamidine. The 99-loop on Tyr99 plays a major role in substrate interaction, it may be rearranged in the factor X activation complex
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