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Literature summary for 3.4.21.22 extracted from

  • Scheiflinger, F.; Dockal, M.; Rosing, J.; Kerschbaumer, R.J.
    Enhancement of the enzymatic activity of activated coagulation factor IX by anti-factor IX antibodies (2008), J. Thromb. Haemost., 6, 315-322.
    View publication on PubMed
Search for more literature for 3.4.21.22

Activating Compound

Activating Compound Comment Organism Structure
factor IX-specific antibodies antibosies specific for human factor I, e.g. 198A1, 198B3, and 224F3, enhance the factor IXa activity mimicking the stimulatory effect of FVIIIa, and thus can replace FVIIIa as cofactor in the FX activation reaction, overview Homo sapiens
Factor VIIIa binds to the activated factor IX and enhances the activation of factor X by several orders of magnitude Homo sapiens
Phospholipid the reaction is performed by the intrinsic FX-activating complex consisting of FIXa and FVIIIa on a negatively charged phospholipid surface in presence of Ca2+ Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ the reaction is performed by the intrinsic FX-activating complex consisting of FIXa and FVIIIa on a negatively charged phospholipid surface in presence of Ca2+ Homo sapiens
Na+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor X + H2O Homo sapiens the enzyme acts in complex with factor VIIIa, FVIIIa deficiency causes the bleeding disorder hemaphilia A activated factor X + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation from plasma Homo sapiens
-
plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor X + H2O the enzyme acts in complex with factor VIIIa, FVIIIa deficiency causes the bleeding disorder hemaphilia A Homo sapiens activated factor X + ?
-
 ?
factor X + H2O the reaction is performed by the intrinsic FX-activating complex consisting of FIXa and FVIIIa on a negatively charged phospholipid surface in presence of Ca2+ Homo sapiens activated factor X + ?
-
 ?

Synonyms

Synonyms Comment Organism
activated coagulation factor IX
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.3 7.4 assay at Homo sapiens