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3.4.11.20: aminopeptidase Ey

This is an abbreviated version!
For detailed information about aminopeptidase Ey, go to the full flat file.

Word Map on EC 3.4.11.20

Reaction

differs from other aminopeptidases in broad specificity for amino acids in the P1 position and the ability to hydrolyse peptides of four or five residues that contain Pro in the P1' position =

Synonyms

aminopeptidase M17, aminopeptidase N, ANPEP, APN1, Leucyl aminopeptidase, M1 aminopeptidase, M1 metalloaminopeptidase, M1-family aminopeptidase, M17 aminopeptidase, M17 leucyl aminopeptidase, malaria M1 metalloaminopeptidase, metallo-aminopeptidase M1, Pf-LAP, PfA-M1, PfA-M1 aminopeptidase, PfA-M17, Xac2987

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.20 aminopeptidase Ey

Turnover Number

Turnover Number on EC 3.4.11.20 - aminopeptidase Ey

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.737
(S)-2-amino-4-cyclohexylbutanoyl-7-amido-4-methylcoumarin
pH 7.4, 37°C
0.456
Ala-7-amido-4-methylcoumarin
pH 7.4, 37°C
9.5 - 15
Arg-Ala
1 - 2.4
His-Ala
0.575
homoargininyl-7-amido-4-methylcoumarin
pH 7.4, 37°C
0.836
homophenylalanyl-7-amido-4-methylcoumarin
pH 7.4, 37°C
1.15
L-Ala 4-nitroanilide
pH 7.2, 37°C
3 - 16
L-alanyl-2-naphthylamide
1.58
L-Arg 4-nitroanilide
pH 7.2, 37°C
9.3 - 21
L-arginyl-2-naphthylamide
1.65
L-Leu 4-nitroanilide
pH 7.2, 37°C
1.55
L-Lys 4-nitroanilide
pH 7.2, 37°C
0.704
L-methionyl-7-amido-4-methylcoumarin
pH 7.4, 37°C
9.3 - 12
Leu-Ala
6.5
Leu-Gly
-
pH 7.5, 30°C
21
Leu-Gly-Gly
-
pH 7.5, 30°C
4.8
Leu-Gly-Leu
-
pH 7.5, 30°C
21
Leu-Gly-NH2
-
pH 7.5, 30°C
12
Leu-Gly-Pro
-
pH 7.5, 30°C
1.4 - 12
Leu-Leu
12
Leu-NH2
-
pH 7.5, 30°C
0.1
Leu-Pro-Leu-Arg-PheNH2
-
-
27
Lys-Ala
5.9 - 7.5
Met-Phe
0.71
norleucyl-7-amido-4-methylcoumarin
pH 7.4, 37°C
0.658
norvalinyl-7-amido-4-methylcoumarin
pH 7.4, 37°C
0.577
styryl-Ala-7-amido-4-methylcoumarin
pH 7.4, 37°C