3.4.11.20: aminopeptidase Ey

This is an abbreviated version!
For detailed information about aminopeptidase Ey, go to the full flat file.

Word Map on EC 3.4.11.20

3.4.11.20

plasmodium

falciparum

antimalarial

aminopeptidases

bestatin

hemoglobin

dipeptide

malarial

subsite

metalloaminopeptidases

yolk

hydroxamic

gallus

leucyl

exopeptidases

domesticus

Reaction

differs from other aminopeptidases in broad specificity for amino acids in the P1 position and the ability to hydrolyse peptides of four or five residues that contain Pro in the P1' position =

Synonyms

aminopeptidase M17, aminopeptidase N, ANPEP, APN1, Leucyl aminopeptidase, M1 aminopeptidase, M1 metalloaminopeptidase, M1-family aminopeptidase, M17 aminopeptidase, M17 leucyl aminopeptidase, malaria M1 metalloaminopeptidase, metallo-aminopeptidase M1, Pf-LAP, PfA-M1, PfA-M1 aminopeptidase, PfA-M17, Xac2987

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.11 Aminopeptidases

3.4.11.20 aminopeptidase Ey

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Results	in table
5	AA Sequence
1	CAS Registry Number
11	Cloned(Commentary)
4	Crystallization (Commentary)
2	Expression
3	General Information
37	IC50 Value
67	Inhibitors
37	kcat/KM [mM/s]
25	Ki Value [mM]
40	KM Value [mM]
7	Localization
23	Metals/Ions
11	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
28	Organism
5	pH Optimum
2	pH Range
1	pH Stability
2	pI Value
3	Posttranslational Modification
2	Protein Variants
9	Purification (Commentary)
2	Reaction
1	Reaction Type
21	Reference
7	Source Tissue
2	Specific Activity [micromol/min/mg]
72	Substrates and Products (Substrate)
9	Subunits
21	Synonyms
3	Temperature Stability [°C]
39	Turnover Number [1/s]

KI Value

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KI Value on EC 3.4.11.20 - aminopeptidase Ey

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0.000029 - 0.00033

(2S,17S,20S,21R)-21-amino-5-(4-benzoylbenzyl)-2-[4-(hex-5-ynoylamino)butyl]-20-hydroxy-17-(naphthalen-2-ylmethyl)-4,7,16,19-tetraoxo-22-phenyl-9,12-dioxa-3,6,15,18-tetraazadocosan-1-amide

2 entries

0.000025 - 0.0038

bestatin

4 entries

0.00048

bestatin methyl ester

2 entries

0.000013

hPhe-PSI[PO2CH2]-Phe

Plasmodium falciparum

Q8IL11

pH and temperature not specified in the publication

718321

0.000014 - 0.0055

N-(1-(4-(1H-pyrazol-1-yl)phenyl)-2-(hydroxyamino)-2-oxoethyl)-3-aminobenzamide

2 entries

0.000011 - 0.0074

N-(1-(4-(1H-pyrazol-1-yl)phenyl)-2-(hydroxyamino)-2-oxoethyl)-4-aminobenzamide

2 entries

0.000028 - 0.0007

N-(1-(4-(1H-pyrazol-1-yl)phenyl)-2-(hydroxyamino)-2-oxoethyl)-pivalamide

2 entries

0.00026 - 0.004

N-[(2-[2-[(N-[(2S,3R)-3-amino-4-[4-(benzyloxy)phenyl]-2-hydroxybutanoyl]-L-alanyl)amino]ethoxy]ethoxy)acetyl]-4-benzoylphenylalanyl-N6-hex-5-ynoyl-L-lysinamide

2 entries

0.000043

N-[(2S,3R)-3-amino-2-hydroxy-4-(4-methoxyphenyl)butanoyl]-L-leucine

Plasmodium falciparum