3.4.11.20: aminopeptidase Ey

This is an abbreviated version!
For detailed information about aminopeptidase Ey, go to the full flat file.

Reaction

differs from other aminopeptidases in broad specificity for amino acids in the P1 position and the ability to hydrolyse peptides of four or five residues that contain Pro in the P1' position =

Synonyms

aminopeptidase M17, aminopeptidase N, ANPEP, APN1, Leucyl aminopeptidase, M1 aminopeptidase, M1 metalloaminopeptidase, M1-family aminopeptidase, M17 aminopeptidase, M17 leucyl aminopeptidase, malaria M1 metalloaminopeptidase, metallo-aminopeptidase M1, Pf-LAP, PfA-M1, PfA-M1 aminopeptidase, PfA-M17, Xac2987

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.11 Aminopeptidases

                3.4.11.20 aminopeptidase Ey

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Results	in table
5	AA Sequence
1	CAS Registry Number
11	Cloned(Commentary)
4	Crystallization (Commentary)
2	Expression
3	General Information
37	IC50 Value
67	Inhibitors
37	kcat/KM [mM/s]
25	Ki Value [mM]
40	KM Value [mM]
7	Localization
23	Metals/Ions
11	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
28	Organism
5	pH Optimum
2	pH Range
1	pH Stability
2	pI Value
3	Posttranslational Modification
2	Protein Variants
9	Purification (Commentary)
2	Reaction
1	Reaction Type
21	Reference
7	Source Tissue
2	Specific Activity [micromol/min/mg]
72	Substrates and Products (Substrate)
9	Subunits
21	Synonyms
3	Temperature Stability [°C]
39	Turnover Number [1/s]

Reference

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Reference on EC 3.4.11.20 - aminopeptidase Ey

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

95176

Ichishima, E.; Yamagata, Y.; Chiba, H.; Sawaguchi, K.; Tanaka, T.

Soluble and bound forms of aminopeptidase in hen's egg yolk

Agric. Biol. Chem.

53

1867-1872

1989

Gallus gallus

-

brenda

647082

Tanaka, T.; Ichishima, E.

Substrate specificity of aminopeptidase Ey from hens (Gallus domesticus) egg yolk

Comp. Biochem. Physiol. B

105

105-110

1993

Gallus gallus

7684960

brenda

647083

Tanaka, T.; Ichishima, E.

Molecular properties of aminopeptidase Ey as a zinc-metalloenzyme

Int. J. Biochem.

25

1681-1688

1993

Gallus gallus

8288037

brenda

647085

Midorikawa, T.; Abe, R.; Yamagata, Y.; Nakajima, T.; Ichishima, E.

Isolation and characterization of cDNA encoding chicken egg yolk aminopeptidase Ey

Comp. Biochem. Physiol. B

119

513-520

1998

Gallus gallus

9734335

brenda

665073

Ichishima, E.

Aminopeptidase Ey

Handbook of Proteolytic Enzymes (2nd Edition)

1

294-296

2004

Gallus gallus

-

brenda

681299

Flipo, M.; Beghyn, T.; Leroux, V.; Florent, I.; Deprez, B.P.; Deprez-Poulain, R.F.

Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents

J. Med. Chem.

50

1322-1334

2007

Plasmodium falciparum, Plasmodium falciparum FcB1

17326615

brenda

682660

Santos, K.; Medrano, F.J.

Expression, purification, and characterization of an aminopeptidase (Xac2987) with broad specificity from Xanthomonas axonopodis pv. citri

Protein Expr. Purif.

52

117-122

2007

Xanthomonas axonopodis

17110128

brenda

717834

Ragheb, D.; Dalal, S.; Bompiani, K.M.; Ray, W.K.; Klemba, M.

Distribution and biochemical properties of an M1-family aminopeptidase in Plasmodium falciparum indicate a role in vacuolar hemoglobin catabolism

J. Biol. Chem.

286

27255-27265

2011

Plasmodium falciparum (Q8IEK1), Plasmodium falciparum

21659511

brenda

717972

Velmourougane, G.; Harbut, M.B.; Dalal, S.; McGowan, S.; Oellig, C.A.; Meinhardt, N.; Whisstock, J.C.; Klemba, M.; Greenbaum, D.C.

Synthesis of new (-)-bestatin-based inhibitor libraries reveals a novel binding mode in the S1 pocket of the essential malaria M1 metalloaminopeptidase

J. Med. Chem.

54

1655-1666

2011

Plasmodium falciparum

21366301

brenda

718071

Azimzadeh, O.; Sow, C.; Geze, M.; Nyalwidhe, J.; Florent, I.

Plasmodium falciparum PfA-M1 aminopeptidase is trafficked via the parasitophorous vacuole and marginally delivered to the food vacuole

Malar. J.

9

189

2010

Plasmodium falciparum (O96935), Plasmodium falciparum

20591164

brenda

718321

McGowan, S.; Oellig, C.A.; Birru, W.A.; Caradoc-Davies, T.T.; Stack, C.M.; Lowther, J.; Skinner-Adams, T.; Mucha, A.; Kafarski, P.; Grembecka, J.; Trenholme, K.R.; Buckle, A.M.; Gardiner, D.L.; Dalton, J.P.; Whisstock, J.C.

Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases

Proc. Natl. Acad. Sci. USA

107

2449-2454

2010

Plasmodium falciparum (Q8IL11), Plasmodium falciparum

20133789

brenda

718330

Harbut, M.B.; Velmourougane, G.; Dalal, S.; Reiss, G.; Whisstock, J.C.; Onder, O.; Brisson, D.; McGowan, S.; Klemba, M.; Greenbaum, D.C.

Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases

Proc. Natl. Acad. Sci. USA

108

E526-E534

2011

Plasmodium falciparum, Plasmodium falciparum (Q8IL11)

21844374

brenda

731736

Gras, S.; Byzia, A.; Gilbert, F.B.; McGowan, S.; Drag, M.; Silvestre, A.; Niepceron, A.; Lecaille, F.; Lalmanach, G.; Brossier, F.

Aminopeptidase N1 (EtAPN1), an M1 metalloprotease of the apicomplexan parasite Eimeria tenella, participates in parasite development

Eukaryot. Cell

13

884-895

2014

Eimeria tenella (V5T9T8), Eimeria tenella

24839124

brenda

732315

Mistry, S.N.; Drinkwater, N.; Ruggeri, C.; Sivaraman, K.K.; Loganathan, S.; Fletcher, S.; Drag, M.; Paiardini, A.; Avery, V.M.; Scammells, P.J.; McGowan, S.

Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors

J. Med. Chem.

57

9168-9183

2014

Plasmodium falciparum (O96935), Plasmodium falciparum (Q8IL11), Plasmodium falciparum, Plasmodium falciparum isolate FcB1/Columbia (O96935)

25299353

brenda

732472

Dalal, S.; Ragheb, D.R.; Klemba, M.

Engagement of the S1, S1' and S2' subsites drives efficient catalysis of peptide bond hydrolysis by the M1-family aminopeptidase from Plasmodium falciparum

Mol. Biochem. Parasitol.

183

70-77

2012

Plasmodium falciparum

22348949

brenda

732862

Gonzalez-Bacerio, J.; Osuna, J.; Ponce, A.; Fando, R.; Figarella, K.; Mendez, Y.; Charli, J.L.; Chavez, M.D.

High-level expression in Escherichia coli, purification and kinetic characterization of Plasmodium falciparum M1-aminopeptidase

Protein Expr. Purif.

104C

103-114

2014

Plasmodium falciparum (Q8IEK1)

25123643

brenda

732895

Drinkwater, N.; Bamert, R.S.; Kannan Sivaraman, K.; Paiardini, A.; McGowan, S.

X-ray crystal structures of an orally available aminopeptidase inhibitor, tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17

Proteins

83

789-795

2015

Plasmodium falciparum (O96935), Plasmodium falciparum (Q8IL11), Plasmodium falciparum, Plasmodium falciparum isolate FcB1/Columbia (O96935)

25645579

brenda

755219

Da Silva, M.; Labas, V.; Nys, Y.; R�hault-Godbert, S.

Investigating proteins and proteases composing amniotic and allantoic fluids during chicken embryonic development

Poult. Sci.

96

2931-2941

2017

Gallus gallus (O57579)

28379482

brenda

Entries 1 - 20 of 18

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