3.2.1.76: L-iduronidase

This is an abbreviated version!
For detailed information about L-iduronidase, go to the full flat file.

Word Map on EC 3.2.1.76

3.2.1.76

mucopolysaccharidosis

lysosomal

hurler

glycosaminoglycans

scheie

dermatan

heparan

hurler-scheie

hematopoietic

corneal

medicine

mucopolysaccharide

intrathecal

clouding

hepatosplenomegaly

iduronate

pompe

pharmacology

enzyme-replacement

4-methylumbelliferyl

facies

mckusick

diagnostics

dysostosis

fabry

drug development

gaucher

Reaction

O-(alpha-L-iduronic acid)-(1-4)-D-O-(alpha glucosamine 6-sulfate)-(1-4)-L-O-(alpha-L-iduronic acid)-D-O-2,5-anhydro-mannitol 6-sulfate

D-O-(alpha glucosamine 6-sulfate)-(1-4)-L-O-(alpha-L-iduronic acid)-D-O-2,5-anhydro-mannitol 6-sulfate

Synonyms

Aldurazyme, alpha-IDUA, alpha-iduronidase, alpha-L-iduronidase, alpha-L-iduronidase A, glycosaminoglycan alpha-L-iduronohydrolase, hIDUA, IDU, IDUA, iduronidase, laronidase, More, rIDUA_RLT

ECTree

3 Hydrolases

3.2 Glycosylases

3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

3.2.1.76 L-iduronidase

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Results	in table
8	Activating Compound
25	AA Sequence
21	Application
1	CAS Registry Number
23	Cloned(Commentary)
3	Crystallization (Commentary)
1677	Disease/ Diagnostics
1	Expression
16	General Information
2	General Stability
4	IC50 Value
35	Inhibitors
7	Ki Value [mM]
43	KM Value [mM]
25	Localization
30	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
212	Organism
2	Pathway
20	PDB ID
15	pH Optimum
1	pH Range
2	pH Stability
17	Posttranslational Modification
94	Protein Variants
16	Purification (Commentary)
2	Reaction
73	Reference
60	Source Tissue
28	Specific Activity [micromol/min/mg]
1	Storage Stability
68	Substrates and Products (Substrate)
13	Subunits
94	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
3	Temperature Stability [°C]
3	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.2.1.76 - L-iduronidase

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0.0651

(1R,2R,3R,4S,5S,6R)-3,4,5-trihydroxy-7-[8-[4-([[6-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)hexanoyl]amino]methyl)-1H-1,2,3-triazol-1-yl]octyl]-7-azabicyclo[4.1.0]heptane-2-carboxylic acid

Homo sapiens

P35475

pH and temperature not specified in the publication

750300

0.0406

(1R,2R,3R,4S,5S,6R)-7-(8-azidooctyl)-3,4,5-trihydroxy-7-azabicyclo[4.1.0]heptane-2-carboxylic acid

Homo sapiens

P35475

pH and temperature not specified in the publication

750300

0.0122

(1R,2S,3S,4R,5S,6R)-7-(8-azidooctyl)-5-(hydroxymethyl)-7-azabicyclo[4.1.0]heptane-2,3,4-triol

Homo sapiens

P35475

pH and temperature not specified in the publication

750300

0.0581

2-[(1E,3E,5E)-5-[1-(6-[[(1-[8-[(1R,2R,3R,4S,5S,6R)-2-carboxy-3,4,5-trihydroxy-7-azabicyclo[4.1.0]heptan-7-yl]octyl]-1H-1,2,3-triazol-4-yl)methyl]amino]-6-oxohexyl)-3,3-dimethyl-1,3-dihydro-2H-indol-2-ylidene]penta-1,3-dien-1-yl]-1,3,3-trimethyl-3H-indol-1-ium

Homo sapiens

P35475

pH and temperature not specified in the publication

750300