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3.2.1.76: L-iduronidase

This is an abbreviated version!
For detailed information about L-iduronidase, go to the full flat file.

Word Map on EC 3.2.1.76

Reaction

O-(alpha-L-iduronic acid)-(1-4)-D-O-(alpha glucosamine 6-sulfate)-(1-4)-L-O-(alpha-L-iduronic acid)-D-O-2,5-anhydro-mannitol 6-sulfate
+
H2O
=
D-O-(alpha glucosamine 6-sulfate)-(1-4)-L-O-(alpha-L-iduronic acid)-D-O-2,5-anhydro-mannitol 6-sulfate
 +
alpha-L-iduronic acid

Synonyms

Aldurazyme, alpha-IDUA, alpha-iduronidase, alpha-L-iduronidase, alpha-L-iduronidase A, glycosaminoglycan alpha-L-iduronohydrolase, hIDUA, IDU, IDUA, iduronidase, laronidase, More, rIDUA_RLT

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.76 L-iduronidase

KI Value

KI Value on EC 3.2.1.76 - L-iduronidase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5
(5R,6R,7S,8S)-5,6,7,8-tetrahydro-6,7,8-trihydroxytetrazolo[1,2-a]pyridine-5-carboxylate
-
Ki above 5 mM, at pH 4.5 and 37°C
5
(5R,6S,7S,8S)-5,6,7,8-tetrahydro-6,7,8-trihydroxytetrazolo[1,2-a]pyridine-5-carboxylate
-
Ki above 5 mM, at pH 4.5 and 37°C
1.3
(5S,6R,7S,8S)-5,6,7,8-tetrahydro-6,7,8-trihydroxytetrazolo[1,2-a]pyridine-5-carboxylate
-
at pH 4.5 and 37°C
0.0046
2-fluoro-alpha-L-idopyranosyluronic acid fluoride
-
pH 4.5, 37°C
0.0012
5-fluoro-alpha-L-idopyranosyluronic acid fluoride
-
pH 4.5, 37°C
0.094
6-sodium-5-amino-5-deoxy-L-idarate-1,5-lactam
-
at pH 4.5 and 37°C
1831
NaCl
-
pH 2.8, 37°C, enzyme from healthy individuals