3.2.1.76: L-iduronidase

This is an abbreviated version!
For detailed information about L-iduronidase, go to the full flat file.

Word Map on EC 3.2.1.76

3.2.1.76

mucopolysaccharidosis

lysosomal

hurler

glycosaminoglycans

scheie

dermatan

heparan

hurler-scheie

hematopoietic

corneal

medicine

mucopolysaccharide

intrathecal

clouding

hepatosplenomegaly

iduronate

pompe

pharmacology

enzyme-replacement

4-methylumbelliferyl

facies

mckusick

diagnostics

dysostosis

fabry

drug development

gaucher

Reaction

O-(alpha-L-iduronic acid)-(1-4)-D-O-(alpha glucosamine 6-sulfate)-(1-4)-L-O-(alpha-L-iduronic acid)-D-O-2,5-anhydro-mannitol 6-sulfate

D-O-(alpha glucosamine 6-sulfate)-(1-4)-L-O-(alpha-L-iduronic acid)-D-O-2,5-anhydro-mannitol 6-sulfate

Synonyms

Aldurazyme, alpha-IDUA, alpha-iduronidase, alpha-L-iduronidase, alpha-L-iduronidase A, glycosaminoglycan alpha-L-iduronohydrolase, hIDUA, IDU, IDUA, iduronidase, laronidase, More, rIDUA_RLT

ECTree

3 Hydrolases

3.2 Glycosylases

3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

3.2.1.76 L-iduronidase

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Results	in table
8	Activating Compound
25	AA Sequence
21	Application
1	CAS Registry Number
23	Cloned(Commentary)
3	Crystallization (Commentary)
1677	Disease/ Diagnostics
1	Expression
16	General Information
2	General Stability
4	IC50 Value
35	Inhibitors
7	Ki Value [mM]
43	KM Value [mM]
25	Localization
30	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
212	Organism
2	Pathway
20	PDB ID
15	pH Optimum
1	pH Range
2	pH Stability
17	Posttranslational Modification
94	Protein Variants
16	Purification (Commentary)
2	Reaction
73	Reference
60	Source Tissue
28	Specific Activity [micromol/min/mg]
1	Storage Stability
68	Substrates and Products (Substrate)
13	Subunits
94	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
3	Temperature Stability [°C]
3	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 3.2.1.76 - L-iduronidase

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125000

Homo sapiens

x * 83000, recombinant wild-type enzyme, SDS-PAGE, x * 125000, recombinant RAP-fusion enzyme, SDS-PAGE

30000

2 * 30000, SDS-PAGE

31000

2 * 31000, SDS-PAGE

480000

gel filtration and native PAGE

732391

49000

Homo sapiens

P35475

x * 77000, recombinant wild-tyype enzyme, extracellular secreted precursor enzyme form, SDS-PAGE, x * 74000, recombinant wild-type enzyme, intracellular precursor enzyme form, SDS-PAGE, x * 69000, recombinant wild-type enzyme, intracellular processed enzyme form 1, SDS-PAGE, x * 65000, recombinant wild-type enzyme, intracellular processed enzyme form 2, SDS-PAGE, x * 49000, recombinant wild-type enzyme, intracellular processed enzyme form 3, SDS-PAGE

60000

65000

67000

gel filtration, L-iduronidase II

171554

68000

Homo sapiens

gel filtration, soluble form

69000

69908

x * 69908, sequence calculation

70000

gel filtration

74000

76000

Western blot analysis, mature component after incorporation into cells

696554

76600

Homo sapiens

x * 76600, recombinant glycosylated enzyme expressed from Brassica napus seeds, SDS-PAGE, x * 76700, recombinant glycosylated enzyme expressed from Nicotiana tabacum seeds, SDS-PAGE

710326

76700

Homo sapiens

x * 76600, recombinant glycosylated enzyme expressed from Brassica napus seeds, SDS-PAGE, x * 76700, recombinant glycosylated enzyme expressed from Nicotiana tabacum seeds, SDS-PAGE

77000

78000

x * 78000, recombinant glycosylated enzyme, SDS-PAGE

79000

SDS-PAGE

83000

85000

87000

gel filtration, L-iduronidase I

171554