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3.2.1.76: L-iduronidase

This is an abbreviated version!
For detailed information about L-iduronidase, go to the full flat file.

Word Map on EC 3.2.1.76

Reaction

O-(alpha-L-iduronic acid)-(1-4)-D-O-(alpha glucosamine 6-sulfate)-(1-4)-L-O-(alpha-L-iduronic acid)-D-O-2,5-anhydro-mannitol 6-sulfate
+
H2O
=
D-O-(alpha glucosamine 6-sulfate)-(1-4)-L-O-(alpha-L-iduronic acid)-D-O-2,5-anhydro-mannitol 6-sulfate
 +
alpha-L-iduronic acid

Synonyms

Aldurazyme, alpha-IDUA, alpha-iduronidase, alpha-L-iduronidase, alpha-L-iduronidase A, glycosaminoglycan alpha-L-iduronohydrolase, hIDUA, IDU, IDUA, iduronidase, laronidase, More, rIDUA_RLT

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.76 L-iduronidase

Inhibitors

Inhibitors on EC 3.2.1.76 - L-iduronidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1R,2R,3R,4S,5S,6R)-3,4,5-trihydroxy-7-[8-[4-([[6-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)hexanoyl]amino]methyl)-1H-1,2,3-triazol-1-yl]octyl]-7-azabicyclo[4.1.0]heptane-2-carboxylic acid
-
(1R,2R,3R,4S,5S,6R)-7-(8-azidooctyl)-3,4,5-trihydroxy-7-azabicyclo[4.1.0]heptane-2-carboxylic acid
irreversible inhibitor
(1R,2S,3S,4R,5S,6R)-7-(8-azidooctyl)-5-(hydroxymethyl)-7-azabicyclo[4.1.0]heptane-2,3,4-triol
-
(2R,3R,4R,5S)-2-carboxy-3,4,5-trihydroxypiperidine
reversible inhibitor
(5R,6R,7S,8S)-5,6,7,8-tetrahydro-6,7,8-trihydroxytetrazolo[1,2-a]pyridine-5-carboxylate
-
-
(5R,6S,7S,8S)-5,6,7,8-tetrahydro-6,7,8-trihydroxytetrazolo[1,2-a]pyridine-5-carboxylate
-
-
(5S,6R,7S,8S)-5,6,7,8-tetrahydro-6,7,8-trihydroxytetrazolo[1,2-a]pyridine-5-carboxylate
-
-
2(S)-carboxy-3(R),4(R),5(S)-trihydroxypiperidine
-
-
2,5-anhydro-D-mannitol
-
-
2,5-anhydro-D-mannitol 6-sulfate
-
-
2-fluoro-alpha-L-idopyranosyluronic acid fluoride
-
reversible, competitive with 4-nitrophenyl-alpha-L-idopyranosiduronate, activity drops down immediately after inhibitor is added
2-[(1E,3E,5E)-5-[1-(6-[[(1-[8-[(1R,2R,3R,4S,5S,6R)-2-carboxy-3,4,5-trihydroxy-7-azabicyclo[4.1.0]heptan-7-yl]octyl]-1H-1,2,3-triazol-4-yl)methyl]amino]-6-oxohexyl)-3,3-dimethyl-1,3-dihydro-2H-indol-2-ylidene]penta-1,3-dien-1-yl]-1,3,3-trimethyl-3H-indol-1-ium
irreversible inhibitor
5-fluoro-alpha-L-idopyranosyl uronic acid fluoride
reversible inhibitor
5-fluoro-alpha-L-idopyranosyluronic acid fluoride
-
reversible, competitive with 4-methylumbelliferyl-alpha-L-iduronide, activity drops down immediately after inhibitor is added
6-sodium-5-amino-5-deoxy-L-idarate-1,5-lactam
-
-
alpha-L-idosyl-(alpha-1,4)2,5-anhydro-D-mannitol 6-sulfate
-
-
CuCl2
D-saccharolactone
-
-
EDTA
-
competitive, equal inhibition of enzyme from healthy individuals and mucopolysaccharidosis type I patients
Fe3+
-
-
Na2SO4
-
-
p-chloromercuribenzoate
-
-
SO42-
-
-
[(2S,3R,4R)-3,4-dihydroxy-5-oxotetrahydrofuran-2-yl](hydroxy)acetic acid
-
competitive inhibitor
additional information
-