3.2.1.76: L-iduronidase

This is an abbreviated version!
For detailed information about L-iduronidase, go to the full flat file.

Word Map on EC 3.2.1.76

3.2.1.76

mucopolysaccharidosis

lysosomal

hurler

glycosaminoglycans

scheie

dermatan

heparan

hurler-scheie

hematopoietic

corneal

medicine

mucopolysaccharide

intrathecal

clouding

hepatosplenomegaly

iduronate

pompe

pharmacology

enzyme-replacement

4-methylumbelliferyl

facies

mckusick

diagnostics

dysostosis

fabry

drug development

gaucher

Reaction

O-(alpha-L-iduronic acid)-(1-4)-D-O-(alpha glucosamine 6-sulfate)-(1-4)-L-O-(alpha-L-iduronic acid)-D-O-2,5-anhydro-mannitol 6-sulfate

D-O-(alpha glucosamine 6-sulfate)-(1-4)-L-O-(alpha-L-iduronic acid)-D-O-2,5-anhydro-mannitol 6-sulfate

Synonyms

Aldurazyme, alpha-IDUA, alpha-iduronidase, alpha-L-iduronidase, alpha-L-iduronidase A, glycosaminoglycan alpha-L-iduronohydrolase, hIDUA, IDU, IDUA, iduronidase, laronidase, More, rIDUA_RLT

ECTree

3 Hydrolases

3.2 Glycosylases

3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

3.2.1.76 L-iduronidase

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Results	in table
8	Activating Compound
25	AA Sequence
21	Application
1	CAS Registry Number
23	Cloned(Commentary)
3	Crystallization (Commentary)
1677	Disease/ Diagnostics
1	Expression
16	General Information
2	General Stability
4	IC50 Value
35	Inhibitors
7	Ki Value [mM]
43	KM Value [mM]
25	Localization
30	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
212	Organism
2	Pathway
20	PDB ID
15	pH Optimum
1	pH Range
2	pH Stability
17	Posttranslational Modification
94	Protein Variants
16	Purification (Commentary)
2	Reaction
73	Reference
60	Source Tissue
28	Specific Activity [micromol/min/mg]
1	Storage Stability
68	Substrates and Products (Substrate)
13	Subunits
94	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
3	Temperature Stability [°C]
3	Turnover Number [1/s]

KM Value

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KM Value on EC 3.2.1.76 - L-iduronidase

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0.016 - 0.14

2,5-anhydro-3-O-alpha-L-idopyranuronosyl-D-mannitol

3 entries

0.002 - 0.12

2,5-anhydro-4-O-alpha-L-idopyranuronosyl-D-mannitol 6-sulfate

3 entries

0.031 - 1.48

4-methylumbelliferyl alpha-L-iduronide

5 entries

0.015 - 1.92

4-methylumbelliferyl-alpha-L-iduronide

16 entries

0.53

4-nitrophenyl-alpha-L-idopyranosiduronate

Homo sapiens

pH 4.5, 37°C

654716

0.08

alpha-L-iduronosyl-(1->3)-2,5-anhydro-D-talitol 4-sulfate

Homo sapiens

171561

anhydromannitol iduronide

Homo sapiens

171555, 171564

0.001 - 0.003

IdoA-GlcNAc6S-IdoA2S-anM6S

2 entries

0.001

IdoA-GlcNH6S-IdoA2S-anM6S

Homo sapiens

pH 3

171566

0.001 - 0.002

IdoA-GlcNS6S-IdoA2S-anM6S

2 entries

0.2 - 1.5

phenyl alpha-L-iduronide

4 entries

additional information

3 entries