3.2.1.24: alpha-mannosidase

This is an abbreviated version!
For detailed information about alpha-mannosidase, go to the full flat file.

Reaction

Synonyms

1,2-alpha-D-mannosidase, 1,2-alpha-mannosidase, acid alpha-mannosidase, acidic alpha-mannosidase, alpha 1,2-mannosidase, Alpha mannosidase 6A8B, alpha-1,2-mannosidase, alpha-1,3 mannosidase, alpha-1,4 mannosidase, alpha-D-mannopyranosidase, alpha-D-mannosidase, Alpha-D-mannoside mannohydrolase, alpha-man, alpha-mann, alpha-mannosidase, alpha-mannosidase C, alpha-mannosidase E-II, alpha-mannosidase I, alpha-mannosidase IA, alpha-mannosidase II, alpha-mannosidase III, alpha1,2-mannosidase, AMAN, class II alpha-mannosidase, CpGH125, ER-alpha-mannosidase, ER-mannosidase II, exo-alpha-mannosidase, GH38 alpha-mannosidase, GH38 alpha-mannosidase II, GH38 class II alpha-mannosidase, GH38 enzyme, Golgi alpha-mannosidase II, Golgi mannosidase IA, Golgi mannosidase IB, Laman, Lysosomal acid alpha-mannosidase, lysosomal alpha-D-mannosidase, lysosomal alpha-mannosidase, Man1p, MAN2B1, Man2C1, Man2C1 alpha-mannosidase, ManA, mannanase, MGG_00994.6, More, neutral alpha-mannosidase, neutral/cytosol mannosidase, p-nitrophenyl-alpha-mannosidase, SpGH125, SpGH38, Ssa-man, SSO3006, TM1851, TMM, velmanase alfa

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

                3.2.1.24 alpha-mannosidase

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Results	in table
24	Activating Compound
3495	AA Sequence
7	Application
1	CAS Registry Number
20	Cloned(Commentary)
10	Crystallization (Commentary)
1134	Disease/ Diagnostics
1	Expression
9	General Information
13	General Stability
32	IC50 Value
334	Inhibitors
46	kcat/KM [mM/s]
57	Ki Value [mM]
113	KM Value [mM]
58	Localization
76	Metals/Ions
91	Molecular Weight [Da]
116	Natural Substrates/ Products (Substrates)
339	Organism
2	Oxidation Stability
3	Pathway
38	PDB ID
89	pH Optimum
14	pH Range
20	pH Stability
24	Posttranslational Modification
56	Protein Variants
84	Purification (Commentary)
5	Reaction
4	Reaction Type
135	Reference
1	Renatured (Commentary)
104	Source Tissue
54	Specific Activity [micromol/min/mg]
12	Storage Stability
317	Substrates and Products (Substrate)
38	Subunits
104	Synonyms
1	Systematic Name
30	Temperature Optimum [°C]
5	Temperature Range [°C]
27	Temperature Stability [°C]
36	Turnover Number [1/s]

pH Optimum

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pH Optimum on EC 3.2.1.24 - alpha-mannosidase

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pH OPTIMUM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

3.4

Styela plicata

-

-

135995

3.5

Trypanosoma cruzi

-

-

135960, 135970

3.5 - 4

Equus caballus

-

isoform alpha-mannosidase I

730990

4

3 entries

4 - 4.5

3 entries

4 - 5

Canavalia ensiformis

-

-

136026

4.1

Medicago sativa

-

-

136003

4.2

3 entries

4.2 - 4.5

Aspergillus flavus

-

-

136009

4.3 - 4.5

2 entries

4.4

Helianthus annuus

-

-

135975

4.4 - 4.6

Rattus sp.

-

-

135984

4.5

6 entries

4.6

4 entries

4.6 - 4.8

Triticum aestivum

-

-

135986

4.8

Aspergillus niger

-

-

136021

4.9 - 5.3

2 entries

5

5 entries

5 - 5.2

Canavalia ensiformis

-

-

135978

5 - 6

Oryctolagus cuniculus

-

-

646586

5.2

Picrophilus torridus

Q6L2X5

maximum activity of ManA

680469

5.5

4 entries

5.5 - 5.9

Rattus sp.

-

-

136017

5.5 - 6

4 entries

5.7

Phlebotomus papatasi

-

assay at, pH-optimum estimated for

679943

5.8

2 entries

6

10 entries

6 - 6.4

Homo sapiens

-

-

136016

6 - 6.5

Aspergillus sp.

-

-

135965

6.1 - 6.5

Rattus sp.

-

-

135974

6.2 - 6.5

Rattus sp.

-

-

135968

6.3

Saccharomyces cerevisiae

-

-

136008

6.4 - 6.8

3 entries

6.5

3 entries

6.5 - 6.7

Spodoptera frugiperda

-

-

646644

6.8

3 entries

7

2 entries

7.4

2 entries

additional information

Homo sapiens

-

alpha-D-mannosidase exists in multiple forms and can be classified on the basis of their optimum pH, into three groups

681902

4

Canavalia ensiformis

-

-

135980

4

Lupinus angustifolius

-

alpha-mannosidase A

135999

4

Turbo cornutus

-

-

136025

4 - 4.5

Citrullus lanatus

-

-

135988

4 - 4.5

Homo sapiens

-

enzyme from lysosomal fraction

656592

4 - 4.5

Homo sapiens

-

lysosomal or acid mannosidases. Neutral optimum pH for endoplasmic reticulum-associated mannosidases

681902

4.2

Aspergillus niger

-

-

136020

4.2

Mus musculus

O09159

isoforms A and B

135961

4.2

Vigna umbellata

-

-

646610

4.3 - 4.5

Oryza sativa

-

reaction with p-nitrophenyl-alpha-mannoside

656917

4.3 - 4.5

Phaseolus vulgaris

-

-

136012

4.5

Canavalia ensiformis

-

-

136015

4.5

Homo sapiens

-

-

135964

4.5

Homo sapiens

O00754

-

750617

4.5

Homo sapiens

-

assay at

678607

4.5

Mus musculus

O09159

-

135962

4.5

Phaseolus vulgaris

-

-

135996

4.6

Erythrina variegata

-

-

678423

4.6

Lupinus angustifolius

-

alpha-mannosidase B

135999

4.6

Rattus sp.

-

-

136006, 136007

4.6

Sus scrofa

-

-

135957, 136022

4.9 - 5.3

Aspergillus oryzae

-

-

136000

4.9 - 5.3

Aspergillus oryzae

-

2-O-alpha-D-mannopyranosyl-D-mannose as substrate

136000

5

Aspergillus phoenicis

-

-

136001, 586942

5

Lablab purpureus

-

acetate buffer

723704

5

Saccharolobus solfataricus

Q97UK5

assay at

724357

5

Saccharolobus solfataricus

Q97UK5

wild-type enzyme and mutant enzymes H228E, H228Q, H533E, and H533Q

729186

5

Solanum lycopersicum

-

substrate 4-nitrophenyl-alpha-D-mannopyranoside

696847

5.5

Rattus sp.

-

-

136013, 136023

5.5

Rattus sp.

-

alpha-mannosidase II with p-nitrophenyl-alpha-D-mannopyranoside as substrate

135998

5.5

Rattus sp.

-

double-peaked pH profile

136014

5.5

Solanum lycopersicum

-

-

715405

5.5 - 6

Homo sapiens

-

-

136004

5.5 - 6

Homo sapiens

-

enzyme from Golgi compartment

656592

5.5 - 6

Homo sapiens

-

Golgi compartment mannosidases. Neutral optimum pH for endoplasmic reticulum-associated mannosidases

681902

5.5 - 6

Vigna radiata

-

-

135992

5.8

Rattus sp.

-

alpha-mannosidase II with Man8GlcNAc as substrate

135998

5.8

Rhodococcus erythropolis

-

in acetate buffer

135985

6

Candida albicans

-

-

135969, 655689

6

Candida albicans

-

enzymes I and II

135956

6

Capsicum annuum

-

assay at

715769

6

Homo sapiens

-

-

135958

6

Rattus sp.

-

-

135993

6

Rattus sp.

-

alpha-mannosidases IA and IB with Man8GlcNAc as substrate

135998

6

Saccharomyces cerevisiae

-

-

135979

6

Solanum lycopersicum

-

substrate Man8GlcNAc2-pyridylaminoside

696847

6

Thermotoga maritima

-

-

654360

6

Yarrowia lipolytica

-

-

135982

6.4 - 6.8

Rattus sp.

-

double-peaked pH profile

136014

6.4 - 6.8

Rattus sp.

-

both isoforms, unbound and Tris-eluted fractions from cobalt-chelating Sepharose

135967

6.4 - 6.8

Saccharomyces cerevisiae

-

-

136011

6.5

Aspergillus fischeri

-

-

698317

6.5

Mus musculus

-

-

135966

6.5

Saccharolobus solfataricus

Q97UK5

assay at

714369

6.8

Gallus gallus

-

-

135963

6.8

Saccharomyces cerevisiae

-

-

136019

6.8

Streptococcus pyogenes M1 GAS

Q99YP5

assay at

710392

7

Homo sapiens

-

enzyme from endoplasmic reticulum

656592

7

Sus scrofa

-

-

135957

7.4

Clostridium perfringens

-

assay at

715596

7.4

Streptococcus pneumoniae

-

assay at

715596