3.2.1.24: alpha-mannosidase

This is an abbreviated version!
For detailed information about alpha-mannosidase, go to the full flat file.

Word Map on EC 3.2.1.24

3.2.1.24

oligosaccharide

mannose

glycosidases

n-linked

swainsonine

hydrolases

mannans

n-glycans

concanavalin

alpha-fucosidase

xylanase

beta-n-acetylglucosaminidase

beta-d-galactosidase

beta-hexosaminidase

cellulase

endo-beta-n-acetylglucosaminidase

high-mannose

beta-d-glucosidase

galactomannans

1-deoxymannojirimycin

asparagine-linked

jack

beta-mannosidase

exoglycosidase

mannosylated

man9glcnac2

n-acetyl-beta-glucosaminidase

locust

beta-d-glucuronidase

complex-type

glucomannans

konjac

mannose-type

hemicellulases

glc3man9glcnac2

castanospermine

oligomannosides

alpha-d-galactosidase

alpha-d-glucosidase

mannose-rich

beta-xylosidase

lipid-linked

hexosaminidase

beta-n-acetylhexosaminidase

mannose-containing

hybrid-type

i-cell

mucolipidosis

oligomannose

analysis

cellulosome

diagnostics

medicine

Reaction

2-O-alpha-D-mannopyranosyl-D-mannopyranose

= 2 alpha-D-mannopyranose

Synonyms

1,2-alpha-D-mannosidase, 1,2-alpha-mannosidase, acid alpha-mannosidase, acidic alpha-mannosidase, alpha 1,2-mannosidase, Alpha mannosidase 6A8B, alpha-1,2-mannosidase, alpha-1,3 mannosidase, alpha-1,4 mannosidase, alpha-D-mannopyranosidase, alpha-D-mannosidase, Alpha-D-mannoside mannohydrolase, alpha-man, alpha-mann, alpha-mannosidase, alpha-mannosidase C, alpha-mannosidase E-II, alpha-mannosidase I, alpha-mannosidase IA, alpha-mannosidase II, alpha-mannosidase III, alpha1,2-mannosidase, AMAN, class II alpha-mannosidase, CpGH125, ER-alpha-mannosidase, ER-mannosidase II, exo-alpha-mannosidase, GH38 alpha-mannosidase, GH38 alpha-mannosidase II, GH38 class II alpha-mannosidase, GH38 enzyme, Golgi alpha-mannosidase II, Golgi mannosidase IA, Golgi mannosidase IB, Laman, Lysosomal acid alpha-mannosidase, lysosomal alpha-D-mannosidase, lysosomal alpha-mannosidase, Man1p, MAN2B1, Man2C1, Man2C1 alpha-mannosidase, ManA, mannanase, MGG_00994.6, More, neutral alpha-mannosidase, neutral/cytosol mannosidase, p-nitrophenyl-alpha-mannosidase, SpGH125, SpGH38, Ssa-man, SSO3006, TM1851, TMM, velmanase alfa

ECTree

3 Hydrolases

3.2 Glycosylases

3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

3.2.1.24 alpha-mannosidase

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Results	in table
24	Activating Compound
3495	AA Sequence
7	Application
1	CAS Registry Number
20	Cloned(Commentary)
10	Crystallization (Commentary)
1134	Disease/ Diagnostics
1	Expression
9	General Information
13	General Stability
32	IC50 Value
334	Inhibitors
46	kcat/KM [mM/s]
57	Ki Value [mM]
113	KM Value [mM]
58	Localization
76	Metals/Ions
91	Molecular Weight [Da]
116	Natural Substrates/ Products (Substrates)
339	Organism
2	Oxidation Stability
3	Pathway
38	PDB ID
89	pH Optimum
14	pH Range
20	pH Stability
24	Posttranslational Modification
56	Protein Variants
84	Purification (Commentary)
5	Reaction
4	Reaction Type
135	Reference
1	Renatured (Commentary)
104	Source Tissue
54	Specific Activity [micromol/min/mg]
12	Storage Stability
317	Substrates and Products (Substrate)
38	Subunits
104	Synonyms
1	Systematic Name
30	Temperature Optimum [°C]
5	Temperature Range [°C]
27	Temperature Stability [°C]
36	Turnover Number [1/s]

KM Value

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KM Value on EC 3.2.1.24 - alpha-mannosidase

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2,4-dinitrophenyl alpha-D-mannoside

Drosophila melanogaster

wild-type enzyme

646638

2,4-dinitrophenyl-alpha-D-mannopyranoside

Trichoderma reesei

pH 5.0, 50°C

654178

0.57 - 2

2-O-alpha-D-mannopyranosyl-D-mannopyranose

2 entries

0.57

2-O-alpha-D-Mannopyranosyl-D-mannose

Aspergillus oryzae

37°C, pH 5.3

136000

3-O-alpha-D-mannopyranosyl-alpha-D-mannopyranose

Streptococcus pyogenes M1 GAS

Q99YP5

pH 6.8, 37°C, recombinant enzyme

710392

0.00731 - 3.6

4-methylumbelliferyl alpha-D-mannopyranoside

3 entries

0.0073 - 5.2

4-methylumbelliferyl-alpha-D-mannopyranoside

9 entries

1.48 - 3.8

4-nitrophenyl alpha-D-mannopyranoside

2 entries

0.11 - 2.9

4-nitrophenyl alpha-D-mannoside

22 entries

0.0826 - 1.8

4-nitrophenyl-alpha-D-mannopyranoside

3 entries

1.6

4-nitrophenyl-alpha-D-mannoside

Capsicum annuum

pH 6.0, 37°C

715769

0.2

5-fluoro-beta-L-gulosyl fluoride

Drosophila melanogaster

wild-type enzyme

646638

0.85 - 2.3

alpha-D-Man-(1->2)-D-Man

2 entries

1.16

alpha-D-Man-(1->3)-D-Man

Saccharolobus solfataricus

Q97UK5

pH 5.0, 70°C, enzyme in complex with Co2+

724357

2 - 2.5

alpha-D-Man-(1->4)-D-Man

2 entries

alpha-D-Man-(1->6)-D-Man

Saccharolobus solfataricus

Q97UK5

pH 5.0, 70°C, enzyme in complex with Co2+

724357

0.839

Man-alpha(1-3)Man

Aspergillus fischeri

pH 6.5, 50°C, 20 min

698317

1.455

Man-alpha(1-6)Man

2 entries

1.13

Man3GlcNAc2

Aspergillus phoenicis

586942

0.065

Man5GlcNAc

Rattus sp.

135974

0.037 - 0.46

Man9GlcNAc

3 entries

1.116

Manalpha(1-2)Man

Aspergillus fischeri

pH 6.5, 50°C

698317

0.839

Manalpha(1-3)Man

Aspergillus fischeri

pH 6.5, 50°C

698317

0.44

Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[Manalpha(1-)]Manbeta(1-4)GlcNAc

Gallus gallus

135963

0.45

Mannan

Aspergillus phoenicis

136001

0.67

mannobiose

Aspergillus phoenicis

135991

0.67

Mannotetraose

Saccharomyces cerevisiae

136011

0.6

methyl-2-O-alpha-D-mannopyranosyl-alpha-D-mannopyranoside

Oryctolagus cuniculus

37°C, pH 6.0

646586

8.2

methyl-4-O-alpha-D-mannopyranosyl-D-mannopyranoside

Aspergillus niger

136020

0.34

methyl-alpha-D-mannopyranoside

Saccharomyces cerevisiae

136011

0.048 - 30

p-nitrophenyl-alpha-D-mannopyranoside

35 entries

1.04

p-nitrophenyl-alpha-D-mannoside

Oryza sativa

656917

0.42

phenyl-alpha-D-mannopyranoside

Saccharomyces cerevisiae

136011

additional information

Mannan

3 entries