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3.2.1.24: alpha-mannosidase

This is an abbreviated version!
For detailed information about alpha-mannosidase, go to the full flat file.

Word Map on EC 3.2.1.24

Reaction

2-O-alpha-D-mannopyranosyl-D-mannopyranose
+
H2O
= 2 alpha-D-mannopyranose

Synonyms

1,2-alpha-D-mannosidase, 1,2-alpha-mannosidase, acid alpha-mannosidase, acidic alpha-mannosidase, alpha 1,2-mannosidase, Alpha mannosidase 6A8B, alpha-1,2-mannosidase, alpha-1,3 mannosidase, alpha-1,4 mannosidase, alpha-D-mannopyranosidase, alpha-D-mannosidase, Alpha-D-mannoside mannohydrolase, alpha-man, alpha-mann, alpha-mannosidase, alpha-mannosidase C, alpha-mannosidase E-II, alpha-mannosidase I, alpha-mannosidase IA, alpha-mannosidase II, alpha-mannosidase III, alpha1,2-mannosidase, AMAN, class II alpha-mannosidase, CpGH125, ER-alpha-mannosidase, ER-mannosidase II, exo-alpha-mannosidase, GH38 alpha-mannosidase, GH38 alpha-mannosidase II, GH38 class II alpha-mannosidase, GH38 enzyme, Golgi alpha-mannosidase II, Golgi mannosidase IA, Golgi mannosidase IB, Laman, Lysosomal acid alpha-mannosidase, lysosomal alpha-D-mannosidase, lysosomal alpha-mannosidase, Man1p, MAN2B1, Man2C1, Man2C1 alpha-mannosidase, ManA, mannanase, MGG_00994.6, More, neutral alpha-mannosidase, neutral/cytosol mannosidase, p-nitrophenyl-alpha-mannosidase, SpGH125, SpGH38, Ssa-man, SSO3006, TM1851, TMM, velmanase alfa

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.24 alpha-mannosidase

Activating Compound

Activating Compound on EC 3.2.1.24 - alpha-mannosidase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-deoxymannojirimycin
-
hydrolysis of p-nitrophenyl-alpha-D-mannopyranoside, slight stimulation for enzyme I at 0.025 mM, enzyme II not affected
2-mercaptoethanol
ATP
-
25% activation at 1 mM
bovine serum albumin
-
CMP
-
25% activation at 1 mM
dithiothreitol
L-cysteine
-
slight stimulation at 1 or 10 mM
L-fucose
-
20% activation at 250 mM
lectin
-
Erythrina indica seed lectin (EiSL) 35% increase alpha-mannosidase in its activity, abolished in presence of lactose
-
Mannan
-
from yeast, 80% activation at 10 mg/ml
NaN3
-
70% stimulation at 10 mM
phosphatidylcholine
-
10fold stimulation at 0.002%
phosphatidylethanolamine
-
8fold stimulation at 0.002%
swainsonine
-
hydrolysis of p-nitrophenyl-alpha-D-mannopyranoside, slight stimulation for enzyme I at 0.025 mM, enzyme II not affected
Triton X-100