3.2.1.130: glycoprotein endo-alpha-1,2-mannosidase

This is an abbreviated version!
For detailed information about glycoprotein endo-alpha-1,2-mannosidase, go to the full flat file.

Word Map on EC 3.2.1.130

3.2.1.130

oligosaccharide

glucosidase

n-linked

deglucosylation

trim

glucosylated

castanospermine

polymannose

glucose-substituted

monoglucosylated

spiro

man8glcnac

1-deoxymannojirimycin

triglucosylated

castanospermine-treated

ii-deficient

1-deoxynojirimycin

paranoia

glc1man9glcnac

medicine

synthesis

Reaction

(Manalpha(1-2)Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manalpha(1-6))(Glcalpha(1-3)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R

(Manalpha(1-2)Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manalpha(1-6))(Manalpha(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R

Synonyms

alpha-1,2-endomannosidase, alpha-endomannosidase, BtGH99, endo-alpha-1,2-mannanase, endo-alpha-1,2-mannosidase, endo-alpha-1->2-mannanase, endo-alpha-D-mannosidase, endo-alpha-mannosidase, endomannosidase, GH99, glucosyl mannosidase, glucosylmannosidase, Golgi endo-a-mannosidase, Golgi-endomannosidase, MANEA

ECTree

3 Hydrolases

3.2 Glycosylases

3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

3.2.1.130 glycoprotein endo-alpha-1,2-mannosidase

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Results	in table
1	Activating Compound
31	AA Sequence
2	Application
2	CAS Registry Number
14	Cloned(Commentary)
3	Crystallization (Commentary)
15	Disease/ Diagnostics
1	Expression
1	General Information
13	Inhibitors
7	kcat/KM [mM/s]
6	KM Value [mM]
35	Localization
13	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
388	Organism
1	Pathway
33	PDB ID
4	pH Optimum
2	pH Range
1	Posttranslational Modification
14	Protein Variants
7	Purification (Commentary)
1	Reaction
1	Reaction Type
45	Reference
62	Source Tissue
1	Specific Activity [micromol/min/mg]
3	Storage Stability
91	Substrates and Products (Substrate)
5	Subunits
42	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
6	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 3.2.1.130 - glycoprotein endo-alpha-1,2-mannosidase

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(3R,4R,5R)-3-(alpha-D-glucopyranosyloxy)-4-hydroxy-5-(hydroxymethyl)piperidine

2 entries

alpha-glucopyranosyl-(1->3)-deoxymannojirimycin

2 entries

alpha-Man-1,3-noeuromycin

Bacteroides xylanisolvens

D6D1V7

potent inhibitor

750913

alpha-mannopyranosyl-(1->3)-isofagomine

Bacteroides xylanisolvens

731659

alpha-mannopyranosyl-1->3-isofagomine

Bacteroides thetaiotaomicron

731659

alpha-mannosyl-1,3-(2-aminodeoxymannojirimycin)

Bacteroides xylanisolvens

D6D1V7

the inhibitor binds like other iminosugar inhibitors. The poor inhibition shown by this compound is not a result of a failure to achieve the expected interaction with the general base, but rather the reduction in basicity of the endocyclic nitrogen caused by introduction of a vicinal, protonated amine at C2

750327

alpha-mannosyl-1,3-mannoimidazole

Bacteroides xylanisolvens

D6D1V7

the inhibitor binds with the imidazole headgroup distorted downwards, a result of an unfavourable interaction with a conserved active site tyrosine

750327

Glucosyl alpha1-3(1-deoxy)mannojirimycin

Rattus norvegicus

646726

additional information

3 entries