3.2.1.130: glycoprotein endo-alpha-1,2-mannosidase

This is an abbreviated version!
For detailed information about glycoprotein endo-alpha-1,2-mannosidase, go to the full flat file.

Word Map on EC 3.2.1.130

3.2.1.130

oligosaccharide

glucosidase

n-linked

deglucosylation

trim

glucosylated

castanospermine

polymannose

glucose-substituted

monoglucosylated

spiro

man8glcnac

1-deoxymannojirimycin

triglucosylated

castanospermine-treated

ii-deficient

1-deoxynojirimycin

paranoia

glc1man9glcnac

medicine

synthesis

Reaction

(Manalpha(1-2)Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manalpha(1-6))(Glcalpha(1-3)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R

(Manalpha(1-2)Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manalpha(1-6))(Manalpha(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R

Synonyms

alpha-1,2-endomannosidase, alpha-endomannosidase, BtGH99, endo-alpha-1,2-mannanase, endo-alpha-1,2-mannosidase, endo-alpha-1->2-mannanase, endo-alpha-D-mannosidase, endo-alpha-mannosidase, endomannosidase, GH99, glucosyl mannosidase, glucosylmannosidase, Golgi endo-a-mannosidase, Golgi-endomannosidase, MANEA

ECTree

3 Hydrolases

3.2 Glycosylases

3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

3.2.1.130 glycoprotein endo-alpha-1,2-mannosidase

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Results	in table
1	Activating Compound
31	AA Sequence
2	Application
2	CAS Registry Number
14	Cloned(Commentary)
3	Crystallization (Commentary)
15	Disease/ Diagnostics
1	Expression
1	General Information
13	Inhibitors
7	kcat/KM [mM/s]
6	KM Value [mM]
35	Localization
13	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
388	Organism
1	Pathway
33	PDB ID
4	pH Optimum
2	pH Range
1	Posttranslational Modification
14	Protein Variants
7	Purification (Commentary)
1	Reaction
1	Reaction Type
45	Reference
62	Source Tissue
1	Specific Activity [micromol/min/mg]
3	Storage Stability
91	Substrates and Products (Substrate)
5	Subunits
42	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
6	Turnover Number [1/s]

Disease

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Disease on EC 3.2.1.130 - glycoprotein endo-alpha-1,2-mannosidase

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Anemia, Aplastic

Integrated analysis of global gene and microRNA expression profiling associated with aplastic anaemia.

31028805

Carcinoma, Hepatocellular

Nonselective utilization of the endomannosidase pathway for processing glycoproteins by human hepatoma (HepG2) cells.

1317871

Infections

Processing of viral envelope glycoprotein by the endomannosidase pathway: evaluation of host cell specificity.

9621113

Lymphoma

Characterization of endomannosidase inhibitors and evaluation of their effect on N-linked oligosaccharide processing during glycoprotein biosynthesis.

8486671

Characterization of the endomannosidase pathway for the processing of N-linked oligosaccharides in glucosidase II-deficient and parent mouse lymphoma cells.

1533222

Virus Diseases

Disaccharides as endomannosidase inhibitors: syntheses of alpha-homomannojirimycin and beta-homomannojirimycin linked to D-glucose and D-mannose.

7774024