3.2.1.130: glycoprotein endo-alpha-1,2-mannosidase

This is an abbreviated version!
For detailed information about glycoprotein endo-alpha-1,2-mannosidase, go to the full flat file.

Word Map on EC 3.2.1.130

3.2.1.130

oligosaccharide

glucosidase

n-linked

deglucosylation

trim

glucosylated

castanospermine

polymannose

glucose-substituted

monoglucosylated

spiro

man8glcnac

1-deoxymannojirimycin

triglucosylated

castanospermine-treated

ii-deficient

1-deoxynojirimycin

paranoia

glc1man9glcnac

medicine

synthesis

Reaction

(Manalpha(1-2)Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manalpha(1-6))(Glcalpha(1-3)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R

(Manalpha(1-2)Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manalpha(1-6))(Manalpha(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R

Synonyms

alpha-1,2-endomannosidase, alpha-endomannosidase, BtGH99, endo-alpha-1,2-mannanase, endo-alpha-1,2-mannosidase, endo-alpha-1->2-mannanase, endo-alpha-D-mannosidase, endo-alpha-mannosidase, endomannosidase, GH99, glucosyl mannosidase, glucosylmannosidase, Golgi endo-a-mannosidase, Golgi-endomannosidase, MANEA

ECTree

3 Hydrolases

3.2 Glycosylases

3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

3.2.1.130 glycoprotein endo-alpha-1,2-mannosidase

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Results	in table
1	Activating Compound
31	AA Sequence
2	Application
2	CAS Registry Number
14	Cloned(Commentary)
3	Crystallization (Commentary)
15	Disease/ Diagnostics
1	Expression
1	General Information
13	Inhibitors
7	kcat/KM [mM/s]
6	KM Value [mM]
35	Localization
13	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
388	Organism
1	Pathway
33	PDB ID
4	pH Optimum
2	pH Range
1	Posttranslational Modification
14	Protein Variants
7	Purification (Commentary)
1	Reaction
1	Reaction Type
45	Reference
62	Source Tissue
1	Specific Activity [micromol/min/mg]
3	Storage Stability
91	Substrates and Products (Substrate)
5	Subunits
42	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
6	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 3.2.1.130 - glycoprotein endo-alpha-1,2-mannosidase

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(3R,4R,5R)-3-(alpha-D-mannopyranosyloxy)-4-hydroxy-5-(hydroxymethyl)-piperidine + H2O

D-mannose + (3R,4R,5R)-3,4-dihydroxy-5-hydroxymethylpiperidine

Bacteroides thetaiotaomicron

731659

(alpha-Man-(1->3)-isofagomine) + H2O

D-mannose + isofagomine

Bacteroides xylanisolvens

731659

3-N-dansylaminopropyl [alpha-D-glucopyranosyl-(1->3)]-alpha-D-mannopyranosyl-(1->2)-alpha-D-mannopyranosyl (1->2)-alpha-D-mannopyranoside + H2O

3-N-dansylaminopropyl-alpha-D-mannopyranosyl-(1->2)-alpha-D-mannopyranoside + ?

Homo sapiens

731506

4-methylumbelliferyl (alpha-D-glucopyranosyl)-(1->3)-alpha-D-mannopyranoside + H2O

2 entries

4-methylumbelliferyl (alpha-D-mannopyranosyl)-(1->3)-alpha-D-mannopyranoside + H2O

2 entries

alpha-glucopyranosyl-(1->3)-alpha-mannopyranosyl fluoride + H2O

4 entries

alpha-mannan + H2O

2 entries

Glc(1->3)Man9GlcNAc2 + H2O

Man8GlcNAc + glucosyl alpha(1->3)-mannose

2 entries

Glc(1->3)Man9GlcNAc2 + H2O

Man8GlcNAc + glucosyl alpha1,3-mannose

2 entries

Glc1Man5GlcNAc1 + H2O

Bos taurus

in general, endomannosidase variants preferentially process monoglucosylated oligosaccharides with truncated mannose chains, i.e. highest levels of activity are observed for Glc1Man5GlcNAc1 and Glc1Man7GlcNAc1/2

731883

Glc2Man9GlcNAc + H2O

Rattus norvegicus

at 14% the rate of GlcMan9GlcNAc hydrolysis

646725

Glc3Man9GlcNAc2 + H2O

3 entries

GlcMan5GlcNAc2 + H2O

alpha-D-glucosyl-1,3-D-mannopyranose + Man4GlcNAc2

2 entries

GlcMan7GlcNAc + H2O

2 entries

GlcMan7GlcNAc2 + H2O

Man6GlcNAc2 + glucosyl alpha(1->3)-D-mannose

2 entries

GlcMan7GlcNAc2 + H2O

Man6GlcNAc2 + glucosyl alpha-(1->3)-D-mannose

2 entries

GlcMan8GlcNAc + H2O

3 entries

GlcMan9GlcNAc + H2O

Man8GlcNAc + glucosyl alpha1,3-mannose

28 entries

GlcMan9GlcNAc2 + H2O

4 entries

GlcMan9GlcNAc2-[protein] + H2O

Man8GlcNAc2-[protein] (isomer 8A1,2,3B1,2) + alpha-D-glucosyl-(1->3)-alpha-D-mannopyranose

Homo sapiens

Q5SRI9

the enzyme removes Glc-alpha-(1->3)-Man unit from G1M9-native and -misfolded-crambins. The enzyme does not have specific preference for correctly folded or misfolded protein structure

750236

human alpha1-antitrypsin + H2O

3 entries

methyl alpha-D-mannopyranosyl-(1->3)-alpha-D-mannopyranosyl-(1->2)-alpha-D-mannopyranosyl-(1->2)-alpha-D-mannopyranoside + H2O

alpha-(1->3)-D-mannobiose + methyl alpha-(1->2)-D-mannobioside + ?

2 entries

vesicular stomatitis virus G protein + H2O

8 entries

additional information

4 entries