3.1.6.12: N-acetylgalactosamine-4-sulfatase

This is an abbreviated version!
For detailed information about N-acetylgalactosamine-4-sulfatase, go to the full flat file.

Reaction

Synonyms

4-sulfatase, 4-sulphatase, acetylgalactosamine 4-sulfatase, ARSB, arylsulfatase B, ASB, chondroitinase, chondroitinsulfatase, chondrosulfatase, G4S, gastric chondrosulfohydrolase, N-acetylgalactosamine 4-sulfatase, N-acetylgalactosamine 4-sulfate sulfohydrolase, N-acetylgalactosamine-4-sulfatase, N-acetylgalactosamine-4-sulphatase, sulfatase, acetylgalactosamine 4-

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.6 Sulfuric-ester hydrolases

                3.1.6.12 N-acetylgalactosamine-4-sulfatase

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Results	in table
7	Activating Compound
120	AA Sequence
21	Application
1	CAS Registry Number
14	Cloned(Commentary)
1	Crystallization (Commentary)
410	Disease/ Diagnostics
2	Expression
23	General Information
2	General Stability
35	Inhibitors
1	Ki Value [mM]
21	KM Value [mM]
22	Localization
13	Metals/Ions
29	Molecular Weight [Da]
45	Natural Substrates/ Products (Substrates)
67	Organism
1	Oxidation Stability
2	Pathway
3	PDB ID
18	pH Optimum
4	pH Range
1	pH Stability
5	Posttranslational Modification
101	Protein Variants
15	Purification (Commentary)
1	Reaction
1	Reaction Type
67	Reference
85	Source Tissue
11	Specific Activity [micromol/min/mg]
2	Storage Stability
128	Substrates and Products (Substrate)
11	Subunits
64	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
16	Temperature Stability [°C]
1	Turnover Number [1/s]

pH Range

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pH Range on EC 3.1.6.12 - N-acetylgalactosamine-4-sulfatase

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

3 - 5

Homo sapiens

-

pH 3.0: about 85% of activity maximum, pH 5.0: about 15% of activity maximum

135548

3.9 - 6.1

Homo sapiens

-

pH 3.9: about 40% of maximal activity, wild-type enzyme, pH 6.1: about 45% of maximal activity, wild-type enzyme. pH 3.9: about 40% of maximal activity, mutant enzyme Y210C, pH 6.1: about 45% of maximal activity, mutant enzyme Y210C

654646

4.8 - 8

Mus musculus

-

pH 4.8: about 80% of maximal activity, pH 8.0: about 60% of maximal activity, enzyme from animals infected with Schistosoma mansoni

655942

5 - 7

Mus musculus

-

pH 5.0: about 20% of maximal activity, pH 7.0: about 55% of maximal activity enzyme from animals without infection

655942