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3.1.6.12: N-acetylgalactosamine-4-sulfatase

This is an abbreviated version!
For detailed information about N-acetylgalactosamine-4-sulfatase, go to the full flat file.

Word Map on EC 3.1.6.12

Reaction

D-GalNAc-4-sulfate
+
H2O
=
sulfate
+
D-GalNAc

Synonyms

4-sulfatase, 4-sulphatase, acetylgalactosamine 4-sulfatase, ARSB, arylsulfatase B, ASB, chondroitinase, chondroitinsulfatase, chondrosulfatase, G4S, gastric chondrosulfohydrolase, N-acetylgalactosamine 4-sulfatase, N-acetylgalactosamine 4-sulfate sulfohydrolase, N-acetylgalactosamine-4-sulfatase, N-acetylgalactosamine-4-sulphatase, sulfatase, acetylgalactosamine 4-

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.6 Sulfuric-ester hydrolases
                3.1.6.12 N-acetylgalactosamine-4-sulfatase

Inhibitors

Inhibitors on EC 3.1.6.12 - N-acetylgalactosamine-4-sulfatase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Borate
Ca2+
-
-
Carbobenzoxyglucosamine 4,6-disulfate
-
competitive to nitrocatechol
ethanol
astrocyte treatment with ethanol inhibits the activity of arylsulfatase B, and triggers the degradation of chondroitin-4-sulfate, increases total sulfated glycosaminoglycans, chondroitin-4-sulfate and neurocan core-protein content and inhibits neurite outgrowth in neurons cocultured with ethanol-treated astrocytes in vitro. Ethanol also inhibits arylsulfatase B activity and increases sulfated glycosaminoglycans and neurocan levels in the developing hippocampus after in vivo ethanol exposure
Glucosamine 4,6-disulfate
-
competitive to nitrocatechol
heparin
-
-
iodoacetate
-
-
K2HPO4
KCl
-
at 10 mM
Na2HPO4
NaCl
-
at 10 mM
NaF
-
-
phosphate
-
-
praziquantel
-
-
SO42-
UDP-N-acetylgalactosamine 4-sulfate
-
competitive to nitrocatechol
vanadate
-
-