3.1.6.12: N-acetylgalactosamine-4-sulfatase

This is an abbreviated version!
For detailed information about N-acetylgalactosamine-4-sulfatase, go to the full flat file.

Word Map on EC 3.1.6.12

3.1.6.12

mucopolysaccharidosis

lysosomal

maroteaux-lamy

glycosaminoglycans

arylsulfatase

dermatan

feline

rhasb

medicine

galsulfase

sulfatases

stair

enzyme-replacement

mps-vi

dysostosis

diagnostics

nutrition

Reaction

Synonyms

4-sulfatase, 4-sulphatase, acetylgalactosamine 4-sulfatase, ARSB, arylsulfatase B, ASB, chondroitinase, chondroitinsulfatase, chondrosulfatase, G4S, gastric chondrosulfohydrolase, N-acetylgalactosamine 4-sulfatase, N-acetylgalactosamine 4-sulfate sulfohydrolase, N-acetylgalactosamine-4-sulfatase, N-acetylgalactosamine-4-sulphatase, sulfatase, acetylgalactosamine 4-

ECTree

3 Hydrolases

3.1 Acting on ester bonds

3.1.6 Sulfuric-ester hydrolases

3.1.6.12 N-acetylgalactosamine-4-sulfatase

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Results	in table
7	Activating Compound
120	AA Sequence
21	Application
1	CAS Registry Number
14	Cloned(Commentary)
1	Crystallization (Commentary)
410	Disease/ Diagnostics
2	Expression
23	General Information
2	General Stability
35	Inhibitors
1	Ki Value [mM]
21	KM Value [mM]
22	Localization
13	Metals/Ions
29	Molecular Weight [Da]
45	Natural Substrates/ Products (Substrates)
67	Organism
1	Oxidation Stability
2	Pathway
3	PDB ID
18	pH Optimum
4	pH Range
1	pH Stability
5	Posttranslational Modification
101	Protein Variants
15	Purification (Commentary)
1	Reaction
1	Reaction Type
67	Reference
85	Source Tissue
11	Specific Activity [micromol/min/mg]
2	Storage Stability
128	Substrates and Products (Substrate)
11	Subunits
64	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
16	Temperature Stability [°C]
1	Turnover Number [1/s]

Posttranslational Modification

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Posttranslational Modification on EC 3.1.6.12 - N-acetylgalactosamine-4-sulfatase

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glycoprotein

2 entries

phosphoprotein

Homo sapiens

compared to degree of mannose-phosphorylation of the wild-type enzyme the mutant enzyme K457R has 33%, mutant enzyme K457S has 50%, mutant enzyme K457G has 31% mutant enzyme K433A has 95%, mutant enzyme K367A has 106% and mutant enzyme K393A has 123% of mannose-phosphorylation

652443

proteolytic modification

Homo sapiens

33% of the intracellular Y210C mutant enzyme remains as a precursor form, for at least 8 h post labeling and is not processed to the mature lysosomal form. A significant amount of the mutant enzyme escapes the endoplasmic reticulum and is either secreted from the expression cells or undergoes delayed intracellular traffic. 67% of the intracellular Y210C mutant enzyme is processed to the mature form by a proteolytic processing step known to occur in lysosomes

654646

additional information

Homo sapiens

P15848

conversion of an active-site cysteine into a formylglycine

663938