3.1.6.12: N-acetylgalactosamine-4-sulfatase

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For detailed information about N-acetylgalactosamine-4-sulfatase, go to the full flat file.

Reaction

Synonyms

4-sulfatase, 4-sulphatase, acetylgalactosamine 4-sulfatase, ARSB, arylsulfatase B, ASB, chondroitinase, chondroitinsulfatase, chondrosulfatase, G4S, gastric chondrosulfohydrolase, N-acetylgalactosamine 4-sulfatase, N-acetylgalactosamine 4-sulfate sulfohydrolase, N-acetylgalactosamine-4-sulfatase, N-acetylgalactosamine-4-sulphatase, sulfatase, acetylgalactosamine 4-

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.6 Sulfuric-ester hydrolases

                3.1.6.12 N-acetylgalactosamine-4-sulfatase

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Results	in table
7	Activating Compound
120	AA Sequence
21	Application
1	CAS Registry Number
14	Cloned(Commentary)
1	Crystallization (Commentary)
410	Disease/ Diagnostics
2	Expression
23	General Information
2	General Stability
35	Inhibitors
1	Ki Value [mM]
21	KM Value [mM]
22	Localization
13	Metals/Ions
29	Molecular Weight [Da]
45	Natural Substrates/ Products (Substrates)
67	Organism
1	Oxidation Stability
2	Pathway
3	PDB ID
18	pH Optimum
4	pH Range
1	pH Stability
5	Posttranslational Modification
101	Protein Variants
15	Purification (Commentary)
1	Reaction
1	Reaction Type
67	Reference
85	Source Tissue
11	Specific Activity [micromol/min/mg]
2	Storage Stability
128	Substrates and Products (Substrate)
11	Subunits
64	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
16	Temperature Stability [°C]
1	Turnover Number [1/s]

Expression

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Expression on EC 3.1.6.12 - N-acetylgalactosamine-4-sulfatase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

differences in distribution, intensity, and pattern of ARSB staining among normal colon, adenomas, and adenocarcinomas is shown. Distinctive, intense luminal membrane staining is present in the normal epithelial cells but reduced in the malignancies and less in the grade 3 than in the grade 1 adenocarcinomas. In the normal cores, a distinctive pattern of intense cytoplasmic positivity at the luminal surface is followed by reduced staining deeper in the crypts

Homo sapiens

-

715789

exposure to 5alpha-dihydrotestosterone increases ARSB and DKK3 promoter methylation, resulting in decreased expression

Homo sapiens

P15848

752087