3.1.6.12: N-acetylgalactosamine-4-sulfatase
This is an abbreviated version!
For detailed information about N-acetylgalactosamine-4-sulfatase, go to the full flat file.
Word Map on EC 3.1.6.12
-
3.1.6.12
-
mucopolysaccharidosis
-
lysosomal
-
maroteaux-lamy
-
glycosaminoglycans
-
arylsulfatase
-
dermatan
-
feline
-
rhasb
-
medicine
-
galsulfase
-
sulfatases
-
stair
-
enzyme-replacement
-
mps-vi
-
dysostosis
-
diagnostics
-
nutrition
- 3.1.6.12
- mucopolysaccharidosis
- lysosomal
-
maroteaux-lamy
- glycosaminoglycans
- arylsulfatase
- dermatan
- feline
-
rhasb
- medicine
-
galsulfase
-
sulfatases
-
stair
-
enzyme-replacement
-
mps-vi
- dysostosis
- diagnostics
- nutrition
Reaction
Synonyms
4-sulfatase, 4-sulphatase, acetylgalactosamine 4-sulfatase, ARSB, arylsulfatase B, ASB, chondroitinase, chondroitinsulfatase, chondrosulfatase, G4S, gastric chondrosulfohydrolase, N-acetylgalactosamine 4-sulfatase, N-acetylgalactosamine 4-sulfate sulfohydrolase, N-acetylgalactosamine-4-sulfatase, N-acetylgalactosamine-4-sulphatase, sulfatase, acetylgalactosamine 4-
ECTree
3.1.6.12 N-acetylgalactosamine-4-sulfataseAdvanced search results
results (
results (Source Tissue
Source Tissue on EC 3.1.6.12 - N-acetylgalactosamine-4-sulfatase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
-
ARSB enzymatic activity is significantly greater in normal than in malignant tissue
-
ARSB enzymatic activity is significantly greater in normal than in malignant tissue
compared to normal prostate cells or stroma, in malignant epithelium, expression of ARSB and Dickkopf Wnt Signaling Pathway Inhibitor DKK3 declines, and expression of galactose-6-sulfate-sulfatase and Wnt signaling targets increases
ARSB is extensively expressed and distributed in the entire spinal cord. Expression in anterior horn of gray matter is significantly higher than that in the posterior horn of gray matter and significantly higher than that in the central canal. ARSB is mainly distributed in the microglia and neuron cells in the wild-type mice
additional information
-
differences in distribution, intensity, and pattern of ARSB staining among normal colon, adenomas, and adenocarcinomas, overview. Distinctive, intense luminal membrane staining is present in the normal epithelial cells but reduced in the malignancies and less in the grade 3 than in the grade 1 adenocarcinomas. ARSB enzymatic activity is significantly greater in normal than in malignant tissue, detailed overview
-
ARSB enzymatic activity is significantly greater in normal than in malignant tissue
-
of animals infected with Schistosoma mansoni. The infection causes a significant increase in activity of arylsulfatase B
in post-natal ventral rat prostate, a distinct and reciprocal localization of arylsulfatase B and N-acetylgalactosamine-6-sulfatase is seen, with arylsulfatase B predominant in the stroma and N-acetylgalactosamine-6-sulfatase predominant in the epithelium. Control arylsulfatase B activity increases significantly between days 5 and 30, but following estrogen exposure, activity is reduced and the observed increase on day 30 is inhibited
