Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.6.12 extracted from

  • Fluharty, A.L.; Stevens, R.L.; Fung, D.; Peak, S.; Kihara, H.
    Uridine diphospho-N-acetylgalactosamine-4-sulfate sulfohydrolase activity of human arylsulfatase B and its deficiency in the Maroteaux-Lamy syndrome (1975), Biochem. Biophys. Res. Commun., 64, 955-962.
    View publication on PubMed
Search for more literature for 3.1.6.12

Application

Application Comment Organism
medicine deficiency in Maroteaux-Lamy syndrome, mucopolysaccharidosis type IV Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.013
-
 UDP-N-acetylgalactosamine 4-sulfate
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetyl-D-galactosamine 4-sulfate units + H2O Homo sapiens acts also on N-acetylglucosamine 4-sulfate N-acetyl-D-galactosamine units + sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-D-galactosamine 4-sulfate units + H2O acts also on N-acetylglucosamine 4-sulfate Homo sapiens N-acetyl-D-galactosamine units + sulfate
-
 ?
p-nitrocatechol sulfate + H2O enzymes catalyze in addition to reaction of EC 3.1.6.12 also arylsulfatase reaction , see also EC 3.1.6.1 Homo sapiens p-nitrocatechol + sulfate
-
 ?
UDP-N-acetylgalactosamine-4-sulfate + H2O
-
 Homo sapiens UDP-N-acetylgalactosamine + sulfate
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
64
-
 loss of activity Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5
-
 UDP-N-acetylgalactosamine 4-sulfate Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
3 5 pH 3.0: about 85% of activity maximum, pH 5.0: about 15% of activity maximum Homo sapiens