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2.1.1.77: protein-L-isoaspartate(D-aspartate) O-methyltransferase

This is an abbreviated version!
For detailed information about protein-L-isoaspartate(D-aspartate) O-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.77

Reaction

S-adenosyl-L-methionine
+
protein L-isoaspartate
=
S-adenosyl-L-homocysteine
 +
protein L-isoaspartate alpha-methyl ester

Synonyms

chaperone protein L-isoaspartate (D-aspartyl) O-methyltransferase, D-aspartyl/L-isoaspartyl methyltransferase, EC 2.1.1.24, HPIMT, IAMT, isoaspartyl peptide methyltransferase, isoaspartyl protein carboxyl-O-methyltransferase, L-aspartyl/L-isoaspartyl protein methyltransferase, L-IAMT, L-isoaspartate O-methyltransferase, L-isoaspartyl (D-aspartyl) methyltransferase, L-isoaspartyl (D-aspartyl) O-methyltransferase, L-isoaspartyl methyltransferase, L-isoaspartyl O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, L-isoaspartyl-O-methyltransferase, L-isoaspartyl/D-aspartyl O-methyltransferase, L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase, methyltransferase, protein (D-aspartate), PCM, PCM-1, PCMT, PCMT1, PIMT, PIMT1, PIMT2, PIMT2 TISIalphaomega, PIMT2 TISIalphapsi, PIMT2 TISIbetapsi, PIMT2 TISIIalphaomega, PIMT2 TISIIalphapsi, PIMT2 TISIIbetapsi, PIMT2 TISIIIalphaomega, PIMT2 TISIIIalphapsi, PIMT2 TISIIIbetapsi, PIMT2', protein (L-isoaspartate) O-methyltransferase, protein carboxyl methyltransferase type II, protein D-aspartate methyltransferase, protein isoaspartate methyl transferase, protein isoaspartate methyltransferase, protein isoaspartyl carboxyl O-methyltransferase, protein isoaspartyl methyltransferase, protein isoaspartyl methyltransferase 1, protein L-isoaspartate (D-aspartate) O-methyltransferase, protein L-isoaspartate methyltransferase, protein L-isoaspartate O-methyltransferase, protein L-isoaspartate-O-methyltransferase, protein L-isoaspartyl (D-aspartate) O-methyltransferase, protein L-isoaspartyl (D-aspartyl) methyltransferase, protein L-isoaspartyl (D-aspartyl) O-methyltransferase, protein L-isoaspartyl methyl transferase, protein L-isoaspartyl methyltransferase, protein L-isoaspartyl methyltransferase1, protein L-isoaspartyl methyltransferase2, protein L-isoaspartyl O-methyltransferase, protein L-isoaspartyl-O-methyltransferase, protein L-isoaspartyl/D-aspartyl O-methyltransferase, protein repair L-isoaspartyl methyltransferase, protein repair L-isoaspartyl methyltransferase 1, protein-beta-aspartate O-methyltransferase, protein-L-isoaspartate (D-aspartate) O-methyltransferase, protein-L-isoaspartate methyltransferase, protein-L-isoaspartate O-methyltransferase, protein-L-isoaspartyl methyltransferase, RPA0376, RPA2838, StoPIMT, type II methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.77 protein-L-isoaspartate(D-aspartate) O-methyltransferase

Cloned

Cloned on EC 2.1.1.77 - protein-L-isoaspartate(D-aspartate) O-methyltransferase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cDNA isolation
-
cDNA isolation, pcm gene cloned and expressed in Escherichia coli BL21(DE3)
-
cloned and expressed in Escherichia coli TOP10
-
disruption of the pcm gene
-
expressed in Arabidopsis thaliana
expressed in Escherichia coli
expressed in Escherichia coli BL21 cells
expressed in Escherichia coli BL21(DE3) cells
expressed in Escherichia coli BL21(DE3)pLysS cells
-
expressed in Escherichia coli BL21(DE3)RIL cells
-
expressed in Escherichia coli NEB5-alpha cells and T7 lys gamma cells
-
expressed in Escherichia coli strain B834 (DE3)
expressed in Escherichia coli Tuner cells
-
expressed in HEK-293 cells
-
expressed in porcine aortic endothelial cells
-
His-tagged enzyme is expressed in Escherichia coli
-
mutant G88A is expressed in Escherichia coli
-
overexpression in Escherichia coli
-
overexpression in transgenic flies extends the normal life span, suggesting that protein damage can be a limiting factor in longevity
overexpression of the enzyme in Escherichia coli increases heat shock survival by a mechanism independent of methyltransferase activity
-
pcm gene PCR amplified, overexpressed in Escherichia coli as a fusion protein
-
pcm gene sequenced
-
PCR amplified cDNA cloned into vector pdeltablue and expressed in Escherichia coli
-
sequence analysis of a cDNA clone of a rat brain enzyme
-
southern blot analysis of PCR amplified genomic DNA, human chromosome contains a single gene encoding the enzyme, PCMT1, mapped to the q24-25 region of chromosome 6
-