2.1.1.77: protein-L-isoaspartate(D-aspartate) O-methyltransferase

This is an abbreviated version!
For detailed information about protein-L-isoaspartate(D-aspartate) O-methyltransferase, go to the full flat file.

Reaction

Synonyms

chaperone protein L-isoaspartate (D-aspartyl) O-methyltransferase, D-aspartyl/L-isoaspartyl methyltransferase, EC 2.1.1.24, HPIMT, IAMT, isoaspartyl peptide methyltransferase, isoaspartyl protein carboxyl-O-methyltransferase, L-aspartyl/L-isoaspartyl protein methyltransferase, L-IAMT, L-isoaspartate O-methyltransferase, L-isoaspartyl (D-aspartyl) methyltransferase, L-isoaspartyl (D-aspartyl) O-methyltransferase, L-isoaspartyl methyltransferase, L-isoaspartyl O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, L-isoaspartyl-O-methyltransferase, L-isoaspartyl/D-aspartyl O-methyltransferase, L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase, methyltransferase, protein (D-aspartate), PCM, PCM-1, PCMT, PCMT1, PIMT, PIMT1, PIMT2, PIMT2 TISIalphaomega, PIMT2 TISIalphapsi, PIMT2 TISIbetapsi, PIMT2 TISIIalphaomega, PIMT2 TISIIalphapsi, PIMT2 TISIIbetapsi, PIMT2 TISIIIalphaomega, PIMT2 TISIIIalphapsi, PIMT2 TISIIIbetapsi, PIMT2', protein (L-isoaspartate) O-methyltransferase, protein carboxyl methyltransferase type II, protein D-aspartate methyltransferase, protein isoaspartate methyl transferase, protein isoaspartate methyltransferase, protein isoaspartyl carboxyl O-methyltransferase, protein isoaspartyl methyltransferase, protein isoaspartyl methyltransferase 1, protein L-isoaspartate (D-aspartate) O-methyltransferase, protein L-isoaspartate methyltransferase, protein L-isoaspartate O-methyltransferase, protein L-isoaspartate-O-methyltransferase, protein L-isoaspartyl (D-aspartate) O-methyltransferase, protein L-isoaspartyl (D-aspartyl) methyltransferase, protein L-isoaspartyl (D-aspartyl) O-methyltransferase, protein L-isoaspartyl methyl transferase, protein L-isoaspartyl methyltransferase, protein L-isoaspartyl methyltransferase1, protein L-isoaspartyl methyltransferase2, protein L-isoaspartyl O-methyltransferase, protein L-isoaspartyl-O-methyltransferase, protein L-isoaspartyl/D-aspartyl O-methyltransferase, protein repair L-isoaspartyl methyltransferase, protein repair L-isoaspartyl methyltransferase 1, protein-beta-aspartate O-methyltransferase, protein-L-isoaspartate (D-aspartate) O-methyltransferase, protein-L-isoaspartate methyltransferase, protein-L-isoaspartate O-methyltransferase, protein-L-isoaspartyl methyltransferase, RPA0376, RPA2838, StoPIMT, type II methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.77 protein-L-isoaspartate(D-aspartate) O-methyltransferase

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Results	in table
4	Activating Compound
23829	AA Sequence
10	Application
1	CAS Registry Number
44	Cloned(Commentary)
21	Cofactor
9	Crystallization (Commentary)
126	Disease/ Diagnostics
20	Expression
40	General Information
2	General Stability
2	IC50 Value
20	Inhibitors
1	Ki Value [mM]
141	KM Value [mM]
65	Localization
56	Molecular Weight [Da]
177	Natural Substrates/ Products (Substrates)
554	Organism
22	PDB ID
14	pH Optimum
6	pH Range
2	pH Stability
10	pI Value
21	Protein Variants
46	Purification (Commentary)
1	Reaction
1	Reaction Type
198	Reference
228	Source Tissue
25	Specific Activity [micromol/min/mg]
2	Storage Stability
466	Substrates and Products (Substrate)
36	Subunits
206	Synonyms
1	Systematic Name
23	Temperature Optimum [°C]
8	Temperature Range [°C]
10	Temperature Stability [°C]
2	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 2.1.1.77 - protein-L-isoaspartate(D-aspartate) O-methyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

S-adenosyl-L-methionine + 60 S ribosomal protein L27

S-adenosyl-L-homocysteine +

Arabidopsis thaliana

-

-

719896

-

-

?

S-adenosyl-L-methionine + 7-nitro-2,1,3-benzoxadiazole-delta sleep-inducing peptide-L-isoaspartate

S-adenosyl-L-homocysteine + 7-nitro-2,1,3-benzoxadiazole-delta sleep-inducing peptide-L-isoaspartate alpha-methyl ester

Homo sapiens

-

-

701664

-

-

?

S-adenosyl-L-methionine + 7-nitro-2,1,3-benzoxadiazole-labeled delta sleep-inducing peptide L-isoaspartate

S-adenosyl-L-homocysteine + 7-nitro-2,1,3-benzoxadiazole-labeled delta sleep-inducing peptide L-isoaspartate methyl ester

Homo sapiens

-

-

719263

-

-

?

S-adenosyl-L-methionine + acid trehalase D-aspartate

S-adenosyl-L-homocysteine + acid trehalase D-aspartate methyl ester

Homo sapiens

-

-

733125

-

-

?

S-adenosyl-L-methionine + actin L-isoaspartate

S-adenosyl-L-homocysteine + actin L-isoaspartate alpha-methyl ester

Homo sapiens

-

-

706415

-

-

?

S-adenosyl-L-methionine + ATHSP17.4 protein

S-adenosyl-L-homocysteine + ?

Arabidopsis thaliana

-

-

719896

-

-

?

S-adenosyl-L-methionine + Bcl-xL L-isoaspartate

S-adenosyl-L-homocysteine + Bcl-xL L-isoaspartate alpha-methyl ester

Homo sapiens

-

-

706415

-

-

?

S-adenosyl-L-methionine + beta-101-lysozyme

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485597

-

-

?

S-adenosyl-L-methionine + bovine serum albumin

S-adenosyl-L-homocysteine + ?

Arabidopsis thaliana

-

-

719896

-

-

?

S-adenosyl-L-methionine + bovine serum albumin L-isoaspartate

S-adenosyl-L-homocysteine + bovine serum albumin L-isoaspartate alpha-methyl ester

Cyberlindnera jadinii

-

enzyme activity is lowest against bovine serum albumin but it doubles when the bovine serum albumin is aged upon incubation in in vitro aging buffer

733240

-

-

?

S-adenosyl-L-methionine + calmodulin

S-adenosyl-L-homocysteine + ?

2 entries

S-adenosyl-L-methionine + carboxyesterase 12

S-adenosyl-L-homocysteine + ?

Arabidopsis thaliana

-

-

719896

-

-

?

S-adenosyl-L-methionine + cinnamoyl-CoA reductase family protein

S-adenosyl-L-homocysteine + ?

Arabidopsis thaliana

-

-

719896

-

-

?

S-adenosyl-L-methionine + delta sleep inducing peptide L-isoaspartate

S-adenosyl-L-homocysteine + delta sleep inducing peptide L-isoaspartate alpha-methyl ester

Cyberlindnera jadinii

-

highest activity

733240

-

-

?

S-adenosyl-L-methionine + delta sleep-inducing peptide

?

Homo sapiens

-

-

702015

-

-

?

S-adenosyl-L-methionine + delta-sleep-inducing peptide L-isoaspartate

S-adenosyl-L-homocysteine + delta-sleep-inducing peptide L-aspartate alpha-methyl ester

Homo sapiens

-

-

705912

-

-

?

S-adenosyl-L-methionine + delta-sleep-inducing peptide L-isoaspartate

S-adenosyl-L-homocysteine + delta-sleep-inducing peptide L-isoaspartate alpha-methyl ester

2 entries

S-adenosyl-L-methionine + DR-Oct-VYPisoDHA

S-adenosyl-L-homocysteine + DR-Oct-VYPisoD(Me)HA

Homo sapiens

-

-

755789

-

-

-

S-adenosyl-L-methionine + early flowering 8 protein

S-adenosyl-L-homocysteine + ?

Arabidopsis thaliana

-

-

719896

-

-

?

S-adenosyl-L-methionine + gamma-globulin

?

Homo sapiens

-

-

758169

-

-

?

S-adenosyl-L-methionine + gamma-globulin

S-adenosyl-L-homocysteine + ?

4 entries

S-adenosyl-L-methionine + gamma-globulin L-isoaspartate

S-adenosyl-L-homocysteine + gamma-globulin L-isoaspartate alpha-methyl ester

Cyberlindnera jadinii

-

-

733240

-

-

?

S-adenosyl-L-methionine + gelatin I

S-adenosyl-L-homocysteine + ?

2 entries

S-adenosyl-L-methionine + GFDL-isoD-GGGVG

S-adenosyl-L-homocysteine + ?

2 entries

S-adenosyl-L-methionine + histidine phosphocarrier protein (isoAsp-38)

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485604

-

-

?

S-adenosyl-L-methionine + histidine phosphocarrier protein-1 (isoAsp-38)

?

Homo sapiens

-

-

485604

-

-

?

S-adenosyl-L-methionine + histidine phosphocarrier protein-2 (isoAsp-12,-38)

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485604

-

-

?

S-adenosyl-L-methionine + histone H2A L-isoaspartate

S-adenosyl-L-homocysteine + histone H2A L-isoaspartate alpha-methyl ester

Gallus gallus

-

in chicken, iso-L-Asp occurs at the Asp121-Ser122 bond in the flexible C-terminal tail of histone H2A

702215

-

-

?

S-adenosyl-L-methionine + histone H2B L-isoaspartate

S-adenosyl-L-homocysteine + histone H2B L-isoaspartate alpha-methyl ester

3 entries

S-adenosyl-L-methionine + histone H4 D-aspartate

S-adenosyl-L-homocysteine + histone H4 D-aspartate methyl ester

Homo sapiens

-

-

735263

-

-

?

S-adenosyl-L-methionine + HPr-2 (isoAsp-12,-38)

?

Homo sapiens

-

-

485604

-

-

?

S-adenosyl-L-methionine + Hsp70 L-isoaspartate

S-adenosyl-L-homocysteine + Hsp70 L-isoaspartate alpha-methyl ester

Homo sapiens

-

-

706415

-

-

?

S-adenosyl-L-methionine + Hsp90 L-isoaspartate

S-adenosyl-L-homocysteine + Hsp90 L-isoaspartate alpha-methyl ester

Homo sapiens

-

-

706415

-

-

?

S-adenosyl-L-methionine + isoACTH

S-adenosyl-L-homocysteine + ?

Bos taurus

-

-

485591

-

-

r

S-adenosyl-L-methionine + isoAsp-DSIP

S-adenosyl-L-homocysteine + isoAsp-alpha-methyl ester-DSIP

Homo sapiens

-

-

758169

-

-

?

S-adenosyl-L-methionine + isoAspDSIP

S-adenosyl-L-homocysteine + ?

Rattus norvegicus

-

-

485606

-

-

?

S-adenosyl-L-methionine + KASA (D-Asp) LAKY

S-adenosyl-L-homocysteine + ?

2 entries

S-adenosyl-L-methionine + KASA (isoD) LAKY

S-adenosyl-L-homocysteine + ?

10 entries

S-adenosyl-L-methionine + KASA(iso-D)LAKY

S-adenosyl-L-homocysteine + KASA(isoaspartate alpha-methyl ester)LAKY

Drosophila melanogaster

Q27869

-

657965

-

-

?

S-adenosyl-L-methionine + KASA(iso-D)LAKY

S-adenosyl-L-homocysteine + KASA(L-isoaspartate alpha-methyl ester)LAKY

Drosophila melanogaster

Q27869

-

657965

-

-

?

S-adenosyl-L-methionine + KASA-iso-L-Asp-LAKY

?

Homo sapiens

-

-

701684

-

-

?

S-adenosyl-L-methionine + KASA-isoD-LAKY

S-adenosyl-L-homocysteine + KASA-isoD alpha methyl ester-LAKY

Rhodopseudomonas palustris

-

-

757230

-

-

?

S-adenosyl-L-methionine + KASA-L-isoAsp-LAKY

S-adenosyl-L-homocysteine + ?

7 entries

S-adenosyl-L-methionine + KASA-L-isoaspartyl-LAKY

S-adenosyl-L-homocysteine + ?

4 entries

S-adenosyl-L-methionine + KMK-isoD-TDSEEEIR

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485604

-

-

?

S-adenosyl-L-methionine + KQVV-isoD-SAYEVIK

S-adenosyl-L-homocysteine + ?

2 entries

S-adenosyl-L-methionine + KVTCK-isoD-GQTNCYQSK

?

Bos taurus

-

-

485597

-

-

?

S-adenosyl-L-methionine + L-Val-L-Tyr-L-Pro-(L-iso-Asp)-L-His-L-Ala

S-adenosyl-L-homocysteine + L-Val-L-Tyr-L-Pro-(L-iso-Asp alpha methyl ester)-L-His-L-Ala

Cicer arietinum

D2IWA7

-

706396

-

-

?

S-adenosyl-L-methionine + LSH-isoD-GY-Cya-L

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485597

-

-

?

S-adenosyl-L-methionine + LSH-isoD-GYCL

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485597

-

-

?

S-adenosyl-L-methionine + mitochondrial glycoprotein family protein/MAM33

S-adenosyl-L-homocysteine + ?

Arabidopsis thaliana

-

-

719896

-

-

?

S-adenosyl-L-methionine + N-succinyl-AAA-p-nitroanilide

S-adenosyl-L-homocysteine + ?

Pyrococcus furiosus

-

-

485622

-

-

?

S-adenosyl-L-methionine + N-succinyl-AAPF-p-nitroanilide

S-adenosyl-L-homocysteine + ?

Pyrococcus furiosus

-

-

485622

-

-

?

S-adenosyl-L-methionine + N-succinyl-AAPL-p-nitroanilide

S-adenosyl-L-homocysteine + ?

Pyrococcus furiosus

-

-

485622

-

-

?

S-adenosyl-L-methionine + N-succinyl-AAV-p-nitroanilide

S-adenosyl-L-homocysteine + ?

Pyrococcus furiosus

-

-

485622

-

-

?

S-adenosyl-L-methionine + N-succinyl-AAVA-p-nitroanilide

S-adenosyl-L-homocysteine + ?

2 entries

S-adenosyl-L-methionine + native lysozyme

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485597

-

-

?

S-adenosyl-L-methionine + oligocellula 2 protein

S-adenosyl-L-homocysteine +

Arabidopsis thaliana

-

-

719896

-

-

?

S-adenosyl-L-methionine + ovalbumin

S-adenosyl-L-homocysteine + ?

16 entries

S-adenosyl-L-methionine + ovalbumin L-isoaspartate

S-adenosyl-L-homocysteine + ovalbumin L-isoaspartate alpha-methyl ester

4 entries

S-adenosyl-L-methionine + PIRL8 protein

S-adenosyl-L-homocysteine + ?

Arabidopsis thaliana

-

-

719896

-

-

?

S-adenosyl-L-methionine + plant RNA helicase 75 L-isoaspartate

S-adenosyl-L-homocysteine + plant RNA helicase 75 L-isoaspartate alpha-methyl ester

Arabidopsis thaliana

-

-

734891

-

-

?

S-adenosyl-L-methionine + PRH75 protein

S-adenosyl-L-homocysteine + ?

Arabidopsis thaliana

-

-

719896

-

-

?

S-adenosyl-L-methionine + protein D-aspartate

S-adenosyl-L-homocysteine + protein D-aspartate beta-methyl ester

11 entries

S-adenosyl-L-methionine + protein D-aspartate

S-adenosyl-L-homocysteine + protein D-aspartate methyl ester

4 entries

S-adenosyl-L-methionine + protein D-isoaspartate

S-adenosyl-L-homocysteine + protein D-isoaspartate alpha-methyl ester

3 entries

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

169 entries

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate methyl ester

Homo sapiens

-

-

719263

-

-

?

S-adenosyl-L-methionine + protein p53

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

the enzyme mediates methylation of protein p53 at isoaspartate residues 29 and 30

720537

-

-

?

S-adenosyl-L-methionine + succinamide

S-adenosyl-L-homocysteine + ?

Pyrococcus furiosus

-

-

485622

-

-

?

S-adenosyl-L-methionine + synapsin I

S-adenosyl-L-homocysteine + ?

2 entries

S-adenosyl-L-methionine + synuclein L-isoaspartate

S-adenosyl-L-homocysteine + synuclein L-isoaspartate alpha-methyl ester

Mus musculus

-

-

735062

-

-

?

S-adenosyl-L-methionine + T1-isoAsp-12

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485604

-

-

?

S-adenosyl-L-methionine + T4-isoAsp-38

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485604

-

-

?

S-adenosyl-L-methionine + UDP-xylose synthase 5

S-adenosyl-L-homocysteine + ?

Arabidopsis thaliana

-

-

719896

-

-

?

S-adenosyl-L-methionine + V2-isoAsp-12

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485604

-

-

?

S-adenosyl-L-methionine + V4-isoAsp-38

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485604

-

-

?

S-adenosyl-L-methionine + Val-Tyr-Pro(L-iso-aspartate)-His-Ala

S-adenosyl-L-homocysteine + Val-Tyr-Pro(L-isoaspartate alpha-methyl ester)-His-Ala

Cicer arietinum

M4I6P1, M4I787

-

734965

-

-

?

S-adenosyl-L-methionine + Val-Tyr-Pro-(isoAsp)-His-Ala

S-adenosyl-L-homocysteine + Val-Tyr-Pro-(isoAsp-alpha-methyl ester)-His-Ala

Rattus norvegicus

-

-

756096

-

-

?

S-adenosyl-L-methionine + VYP (isoD) HA

S-adenosyl-L-homocysteine + ?

5 entries

S-adenosyl-L-methionine + VYP(iso-D)HA

S-adenosyl-L-homocysteine + VYP(isoaspartate alpha-methyl ester)HA

Drosophila melanogaster

Q27869

-

657965

-

-

?

S-adenosyl-L-methionine + VYP(iso-D)HA

S-adenosyl-L-homocysteine + VYP(L-isoaspartate alpha-methyl ester)HA

Drosophila melanogaster

Q27869

-

657965

-

-

?

S-adenosyl-L-methionine + VYP(L-isoaspartate)HA

S-adenosyl-L-homocysteine + VYP(L-isoaspartate alpha-methyl ester)HA

2 entries

S-adenosyl-L-methionine + VYP-(L-iso-Asp)-HA

S-adenosyl-L-homocysteine + VYP-(L-iso-Asp-alpha-methyl ester)-HA

2 entries

S-adenosyl-L-methionine + VYP-D-alpha-Asp-GA

?

Homo sapiens

P22061

-

734535

-

-

?

S-adenosyl-L-methionine + VYP-isoD-AA

?

Bos taurus

-

-

485597

-

-

?

S-adenosyl-L-methionine + VYP-isoD-CA

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485597

-

-

?

S-adenosyl-L-methionine + VYP-isoD-Cya-G

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485597

-

-

?

S-adenosyl-L-methionine + VYP-isoD-DA

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485597

-

-

?

S-adenosyl-L-methionine + VYP-isoD-GA

S-adenosyl-L-homocysteine + ?

2 entries

S-adenosyl-L-methionine + VYP-isoD-HA

S-adenosyl-L-homocysteine + VYP-isoD alpha methyl ester-HA

Rhodopseudomonas palustris

-

-

757230

-

-

?

S-adenosyl-L-methionine + VYP-isoD-SA

?

Bos taurus

-

-

485597

-

-

?

S-adenosyl-L-methionine + VYP-L-beta-Asp-GA

?

Homo sapiens

P22061

-

734535

-

-

?

S-adenosyl-L-methionine + VYP-L-isoAsp-CA

S-adenosyl-L-homocysteine + ?

Arabidopsis thaliana

-

-

485615

-

-

?

S-adenosyl-L-methionine + VYP-L-isoAsp-GA

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485604

-

-

?

S-adenosyl-L-methionine + VYP-L-isoAsp-GHG

S-adenosyl-L-homocysteine + ?

Arabidopsis thaliana

-

-

485615

-

-

?

S-adenosyl-L-methionine + VYP-L-isoAsp-HA

?

Daucus carota

-

-

485618

-

-

?

S-adenosyl-L-methionine + VYP-L-isoAsp-HA

S-adenosyl-L-homocysteine + ?

7 entries

S-adenosyl-L-methionine + VYP-L-isoAsp-RR

S-adenosyl-L-homocysteine + ?

Arabidopsis thaliana

-

-

485615

-

-

?

S-adenosyl-L-methionine + VYP-L-isoaspartyl-HA

S-adenosyl-L-homocysteine + ?

Cucumis sativus

-

-

720328

-

-

?

S-adenosyl-L-methionine + VYR-isoD-RR

S-adenosyl-L-homocysteine + VYR-isoD alpha methyl ester-RR

Rhodopseudomonas palustris

-

-

757230

-

-

?

S-adenosyl-L-methionine + WM-isoD-F-NH2

?

Homo sapiens

-

-

485597

-

-

?

S-adenosyl-L-methionine + YVS-isoAsp-GHG

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485604

-

-

?

S-adenosyl-L-methionine + YVS-isoD-G-Cya-G

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485597

-

-

?

S-adenosyl-L-methionine + YVS-isoD-GCG

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485597

-

-

?

S-adenosyl-L-methionine + YVS-isoD-GDG

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485597

-

-

?

S-adenosyl-L-methionine + YVS-isoD-GHG

S-adenosyl-L-homocysteine + YVS-isoD alpha methyl ester-GHG

Rhodopseudomonas palustris

-

-

757230

-

-

?

additional information

?

-

8 entries

S-adenosyl-L-methionine + calmodulin

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485611, 485617

-

-

?

S-adenosyl-L-methionine + calmodulin

S-adenosyl-L-homocysteine + ?

Xenopus laevis

-

-

485617

-

-

?

S-adenosyl-L-methionine + delta-sleep-inducing peptide L-isoaspartate

S-adenosyl-L-homocysteine + delta-sleep-inducing peptide L-isoaspartate alpha-methyl ester

Gallus gallus

-

delta-sleep-inducing peptide is WAGGDSGE

702215

-

-

?

S-adenosyl-L-methionine + delta-sleep-inducing peptide L-isoaspartate

S-adenosyl-L-homocysteine + delta-sleep-inducing peptide L-isoaspartate alpha-methyl ester

Rattus norvegicus

-

delta-sleep-inducing peptide is WAGGDSGE

702215

-

-

?

S-adenosyl-L-methionine + gamma-globulin

S-adenosyl-L-homocysteine + ?

Arabidopsis thaliana

-

-

485615

-

-

?

S-adenosyl-L-methionine + gamma-globulin

S-adenosyl-L-homocysteine + ?

Bos taurus

-

-

485606

-

-

?

S-adenosyl-L-methionine + gamma-globulin

S-adenosyl-L-homocysteine + ?

Bos taurus

-

-

485591

-

-

r

S-adenosyl-L-methionine + gamma-globulin

S-adenosyl-L-homocysteine + ?

Rattus norvegicus

-

-

485606, 485615

-

-

?

S-adenosyl-L-methionine + gelatin I

S-adenosyl-L-homocysteine + ?

Rattus norvegicus

-

-

485599

-

-

?

S-adenosyl-L-methionine + gelatin I

S-adenosyl-L-homocysteine + ?

Rattus norvegicus Sprague-Dawley

-

-

485599

-

-

?

S-adenosyl-L-methionine + GFDL-isoD-GGGVG

S-adenosyl-L-homocysteine + ?

Bos taurus

-

-

485597

-

-

?

S-adenosyl-L-methionine + GFDL-isoD-GGGVG

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485597

-

-

?

S-adenosyl-L-methionine + histone H2B L-isoaspartate

S-adenosyl-L-homocysteine + histone H2B L-isoaspartate alpha-methyl ester

Gallus gallus

-

in chicken, iso-L-Asp occurs at the Asp26-Lys27 bond in the N-terminal tail of histone H2B

702215

-

-

?

S-adenosyl-L-methionine + histone H2B L-isoaspartate

S-adenosyl-L-homocysteine + histone H2B L-isoaspartate alpha-methyl ester

Homo sapiens

-

-

733992

-

-

?

S-adenosyl-L-methionine + histone H2B L-isoaspartate

S-adenosyl-L-homocysteine + histone H2B L-isoaspartate alpha-methyl ester

Rattus norvegicus

-

in rat, iso-L-Asp occurs at the Asp25-Gly26 bond in the N-terminal tail of histone H2B

702215

-

-

?

S-adenosyl-L-methionine + KASA (D-Asp) LAKY

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485622

-

-

?

S-adenosyl-L-methionine + KASA (D-Asp) LAKY

S-adenosyl-L-homocysteine + ?

Pyrococcus furiosus

-

-

485622

-

-

?

S-adenosyl-L-methionine + KASA (isoD) LAKY

S-adenosyl-L-homocysteine + ?

Bos taurus

-

-

485597

-

-

?

S-adenosyl-L-methionine + KASA (isoD) LAKY

S-adenosyl-L-homocysteine + ?

Caenorhabditis elegans

-

-

485615

-

-

?

S-adenosyl-L-methionine + KASA (isoD) LAKY

S-adenosyl-L-homocysteine + ?

Caenorhabditis elegans

-

synthetic methyl acceptor

485610

-

-

?

S-adenosyl-L-methionine + KASA (isoD) LAKY

S-adenosyl-L-homocysteine + ?

Escherichia coli

-

-

485615

-

-

?

S-adenosyl-L-methionine + KASA (isoD) LAKY

S-adenosyl-L-homocysteine + ?

Escherichia coli

-

synthetic methyl acceptor

485610

-

-

?

S-adenosyl-L-methionine + KASA (isoD) LAKY

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485597

-

-

?

S-adenosyl-L-methionine + KASA (isoD) LAKY

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

synthetic methyl acceptor

485610

-

-

?

S-adenosyl-L-methionine + KASA (isoD) LAKY

S-adenosyl-L-homocysteine + ?

Thermotoga maritima

-

-

485615

-

-

?

S-adenosyl-L-methionine + KASA (isoD) LAKY

S-adenosyl-L-homocysteine + ?

Thermotoga maritima

-

synthetic methyl acceptor

485610

-

-

?

S-adenosyl-L-methionine + KASA (isoD) LAKY

S-adenosyl-L-homocysteine + ?

Triticum aestivum

-

synthetic methyl acceptor

485610

-

-

?

S-adenosyl-L-methionine + KASA-L-isoAsp-LAKY

S-adenosyl-L-homocysteine + ?

Arabidopsis thaliana

-

-

485615, 485618, 485622

-

-

?

S-adenosyl-L-methionine + KASA-L-isoAsp-LAKY

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485615, 485618, 485622

-

-

?

S-adenosyl-L-methionine + KASA-L-isoAsp-LAKY

S-adenosyl-L-homocysteine + ?

Oryza sativa

-

-

485615, 485618

-

-

?

S-adenosyl-L-methionine + KASA-L-isoAsp-LAKY

S-adenosyl-L-homocysteine + ?

Oryza sativa M-101

-

-

485618

-

-

?

S-adenosyl-L-methionine + KASA-L-isoAsp-LAKY

S-adenosyl-L-homocysteine + ?

Pyrococcus furiosus

-

-

485622

-

-

?

S-adenosyl-L-methionine + KASA-L-isoAsp-LAKY

S-adenosyl-L-homocysteine + ?

Triticum aestivum

-

-

485615, 485618

-

-

?

S-adenosyl-L-methionine + KASA-L-isoAsp-LAKY

S-adenosyl-L-homocysteine + ?

Zea mays

-

-

485615, 485618

-

-

?

S-adenosyl-L-methionine + KASA-L-isoaspartyl-LAKY

S-adenosyl-L-homocysteine + ?

Caenorhabditis elegans

-

-

720828

-

-

?

S-adenosyl-L-methionine + KASA-L-isoaspartyl-LAKY

S-adenosyl-L-homocysteine + ?

Caenorhabditis elegans N2

-

-

720828

-

-

?

S-adenosyl-L-methionine + KASA-L-isoaspartyl-LAKY

S-adenosyl-L-homocysteine + ?

Caenorhabditis elegans PL51

-

-

720828

-

-

?

S-adenosyl-L-methionine + KASA-L-isoaspartyl-LAKY

S-adenosyl-L-homocysteine + ?

Cucumis sativus

-

-

720328

-

-

?

S-adenosyl-L-methionine + KQVV-isoD-SAYEVIK

S-adenosyl-L-homocysteine + ?

Bos taurus

-

-

485597

-

-

?

S-adenosyl-L-methionine + KQVV-isoD-SAYEVIK

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485597

-

-

?

S-adenosyl-L-methionine + N-succinyl-AAVA-p-nitroanilide

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485622

-

-

?

S-adenosyl-L-methionine + N-succinyl-AAVA-p-nitroanilide

S-adenosyl-L-homocysteine + ?

Pyrococcus furiosus

-

-

485622

-

-

?

S-adenosyl-L-methionine + ovalbumin

S-adenosyl-L-homocysteine + ?

Arabidopsis thaliana

-

-

485615, 485618, 485622, 719896

-

-

?

S-adenosyl-L-methionine + ovalbumin

S-adenosyl-L-homocysteine + ?

Bos taurus

-

-

485597, 485598

-

-

?

S-adenosyl-L-methionine + ovalbumin

S-adenosyl-L-homocysteine + ?

Caenorhabditis elegans

-

-

485610, 485615, 485618, 485622

-

-

?

S-adenosyl-L-methionine + ovalbumin

S-adenosyl-L-homocysteine + ?

Caenorhabditis elegans N2

-

-

485618

-

-

?

S-adenosyl-L-methionine + ovalbumin

S-adenosyl-L-homocysteine + ?

Cucumis sativus

-

-

720328

-

-

?

S-adenosyl-L-methionine + ovalbumin

S-adenosyl-L-homocysteine + ?

Daucus carota

-

-

485618

-

-

?

S-adenosyl-L-methionine + ovalbumin

S-adenosyl-L-homocysteine + ?

Escherichia coli

-

-

485598, 485610, 485615, 485618, 485622

-

-

?

S-adenosyl-L-methionine + ovalbumin

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485597, 485598, 485610, 485615, 485618, 485622

-

-

?

S-adenosyl-L-methionine + ovalbumin

S-adenosyl-L-homocysteine + ?

Oryza sativa

-

-

485615, 485618

-

-

?

S-adenosyl-L-methionine + ovalbumin

S-adenosyl-L-homocysteine + ?

Oryza sativa M-101

-

-

485618

-

-

?

S-adenosyl-L-methionine + ovalbumin

S-adenosyl-L-homocysteine + ?

Pyrococcus furiosus

-

-

485622

-

-

?

S-adenosyl-L-methionine + ovalbumin

S-adenosyl-L-homocysteine + ?

Rattus norvegicus

-

-

485599, 485610, 485615

-

-

?

S-adenosyl-L-methionine + ovalbumin

S-adenosyl-L-homocysteine + ?

Rattus norvegicus Sprague-Dawley

-

-

485599

-

-

?

S-adenosyl-L-methionine + ovalbumin

S-adenosyl-L-homocysteine + ?

Thermotoga maritima

-

-

485610, 485615, 485622

-

-

?

S-adenosyl-L-methionine + ovalbumin

S-adenosyl-L-homocysteine + ?

Triticum aestivum

-

-

485610, 485615, 485618

-

-

?

S-adenosyl-L-methionine + ovalbumin

S-adenosyl-L-homocysteine + ?

Zea mays

-

-

485615, 485618

-

-

?

S-adenosyl-L-methionine + ovalbumin L-isoaspartate

S-adenosyl-L-homocysteine + ovalbumin L-isoaspartate alpha-methyl ester

Arabidopsis thaliana

-

-

706208

-

-

?

S-adenosyl-L-methionine + ovalbumin L-isoaspartate

S-adenosyl-L-homocysteine + ovalbumin L-isoaspartate alpha-methyl ester

Cyberlindnera jadinii

-

-

733240

-

-

?

S-adenosyl-L-methionine + ovalbumin L-isoaspartate

S-adenosyl-L-homocysteine + ovalbumin L-isoaspartate alpha-methyl ester

Drosophila melanogaster

Q27869

-

657965

-

-

?

S-adenosyl-L-methionine + ovalbumin L-isoaspartate

S-adenosyl-L-homocysteine + ovalbumin L-isoaspartate alpha-methyl ester

Homo sapiens

-

-

706415

-

-

?

S-adenosyl-L-methionine + protein D-aspartate

S-adenosyl-L-homocysteine + protein D-aspartate beta-methyl ester

Arabidopsis thaliana

-

-

485615

-

485615

?

S-adenosyl-L-methionine + protein D-aspartate

S-adenosyl-L-homocysteine + protein D-aspartate beta-methyl ester

Arabidopsis thaliana

-

-

485622

-

-

?

S-adenosyl-L-methionine + protein D-aspartate

S-adenosyl-L-homocysteine + protein D-aspartate beta-methyl ester

Bos taurus

-

-

485597, 485598, 485600

-

-

?

S-adenosyl-L-methionine + protein D-aspartate

S-adenosyl-L-homocysteine + protein D-aspartate beta-methyl ester

Escherichia coli

-

-

485598, 485600, 485615, 485622

-

-

?

S-adenosyl-L-methionine + protein D-aspartate

S-adenosyl-L-homocysteine + protein D-aspartate beta-methyl ester

Homo sapiens

-

-

485593

-

485593

?

S-adenosyl-L-methionine + protein D-aspartate

S-adenosyl-L-homocysteine + protein D-aspartate beta-methyl ester

Homo sapiens

-

-

485597

-

-

?

S-adenosyl-L-methionine + protein D-aspartate

S-adenosyl-L-homocysteine + protein D-aspartate beta-methyl ester

Homo sapiens

-

-

485598

-

485598

?

S-adenosyl-L-methionine + protein D-aspartate

S-adenosyl-L-homocysteine + protein D-aspartate beta-methyl ester

Homo sapiens

-

-

485600

-

485600

?

S-adenosyl-L-methionine + protein D-aspartate

S-adenosyl-L-homocysteine + protein D-aspartate beta-methyl ester

Homo sapiens

-

-

485615

-

485615

?

S-adenosyl-L-methionine + protein D-aspartate

S-adenosyl-L-homocysteine + protein D-aspartate beta-methyl ester

Homo sapiens

-

-

485622

-

-

?

S-adenosyl-L-methionine + protein D-aspartate

S-adenosyl-L-homocysteine + protein D-aspartate beta-methyl ester

Pyrococcus furiosus

-

-

485622

-

-

?

S-adenosyl-L-methionine + protein D-aspartate

S-adenosyl-L-homocysteine + protein D-aspartate methyl ester

Cyberlindnera jadinii

-

-

733240

-

-

?

S-adenosyl-L-methionine + protein D-aspartate

S-adenosyl-L-homocysteine + protein D-aspartate methyl ester

Homo sapiens

-

-

719263, 733251, 733992

-

-

?

S-adenosyl-L-methionine + protein D-aspartate

S-adenosyl-L-homocysteine + protein D-aspartate methyl ester

Homo sapiens

P22061

-

734535

-

-

?

S-adenosyl-L-methionine + protein D-aspartate

S-adenosyl-L-homocysteine + protein D-aspartate methyl ester

Vibrio cholerae serotype O1

-

-

733437

-

-

?

S-adenosyl-L-methionine + protein D-isoaspartate

S-adenosyl-L-homocysteine + protein D-isoaspartate alpha-methyl ester

Arabidopsis thaliana

-

-

719896

-

-

?

S-adenosyl-L-methionine + protein D-isoaspartate

S-adenosyl-L-homocysteine + protein D-isoaspartate alpha-methyl ester

Escherichia coli

P0A7A5

-

719234

-

-

?

S-adenosyl-L-methionine + protein D-isoaspartate

S-adenosyl-L-homocysteine + protein D-isoaspartate alpha-methyl ester

Homo sapiens

-

-

718575

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Agaricus bisporus

-

-

485601

-

485601

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Agaricus bisporus

-

implicated in the repair or degradation of age-damaged proteins that contain atypical L-isoaspartyl residues

485601

-

485601

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Arabidopsis thaliana

-

-

485607

-

485607

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Arabidopsis thaliana

-

-

485615

-

485615

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Arabidopsis thaliana

-

-

485618

-

485618

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Arabidopsis thaliana

-

-

485622

-

485622

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Arabidopsis thaliana

-

-

706232, 734891, 757241

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Arabidopsis thaliana

-

repair enzyme, methylates abnormal L-isoaspartate residues in proteins which arise spontaneously as a result of aging

485615

-

485615

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Arabidopsis thaliana

Q64J17

the spontaneous and deleterious conversion of L-asparaginyl and L-aspartyl protein residues to L-iso-Asp or D-Asp occurs as a proteins age and is accelerated under stressful conditions. Arabidopsis thaliana contains two genes (At3g48330 and At5g50240) encoding protein-L-isoaspartate methyltransferase, an enzyme capable of correcting this damage

660245

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Arabidopsis thaliana

Q64J17

the spontaneous and deleterious conversion of L-asparaginyl and L-aspartyl protein residues to L-iso-Asp or D-Asp occurs as a proteins age and is accelerated under stressful conditions. Arabidopsis thaliana Heynh. contains two genes (At3g48330 and At5g50240) encoding protein-L-isoaspartate methyltransferase, an enzyme capable of correcting this damage

660245

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Arabidopsis thaliana Heynh.

Q64J17

the spontaneous and deleterious conversion of L-asparaginyl and L-aspartyl protein residues to L-iso-Asp or D-Asp occurs as a proteins age and is accelerated under stressful conditions. Arabidopsis thaliana contains two genes (At3g48330 and At5g50240) encoding protein-L-isoaspartate methyltransferase, an enzyme capable of correcting this damage

660245

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Arabidopsis thaliana Heynh.

Q64J17

the spontaneous and deleterious conversion of L-asparaginyl and L-aspartyl protein residues to L-iso-Asp or D-Asp occurs as a proteins age and is accelerated under stressful conditions. Arabidopsis thaliana Heynh. contains two genes (At3g48330 and At5g50240) encoding protein-L-isoaspartate methyltransferase, an enzyme capable of correcting this damage

660245

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Archaeoglobus fulgidus

-

-

485610

-

485610

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Armadillidium pulchellum

-

-

485601

-

485601

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Armadillidium pulchellum

-

implicated in the repair or degradation of age-damaged proteins that contain atypical L-isoaspartyl residues

485601

-

485601

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Bos taurus

-

-

485592

-

485592

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Bos taurus

-

-

485594

-

485594

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Bos taurus

-

-

485595

-

485595

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Bos taurus

-

-

485596

-

485596

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Bos taurus

-

-

485597

-

485597

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Bos taurus

-

-

485598

-

485598

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Bos taurus

-

-

485600

-

485600

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Bos taurus

-

-

485605

-

485605

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Bos taurus

-

-

485606

-

485606

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Bos taurus

-

-

485591

-

485591

r

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Bos taurus

-

key role in degradation or repair of deamination damaged proteins

485592

-

485592

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Caenorhabditis elegans

-

-

485610

-

485610

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Caenorhabditis elegans

-

-

485614

-

485614

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Caenorhabditis elegans

-

-

485615

-

485615

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Caenorhabditis elegans

-

-

485618

-

485618

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Caenorhabditis elegans

-

-

485622

-

485622

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Caenorhabditis elegans

-

-

705487, 720828

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Caenorhabditis elegans N2

-

-

720828

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Caenorhabditis elegans N2

-

-

485618

-

485618

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Caenorhabditis elegans PL51

-

-

720828

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Cicer arietinum

M4I6P1, M4I787

-

734965

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Cyberlindnera jadinii

-

-

733240

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Daucus carota

-

-

485618

-

485618

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Drosophila melanogaster

-

-

485600

-

485600

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Drosophila melanogaster

-

-

485612

-

485612

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Drosophila melanogaster

-

-

485615

-

485615

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Drosophila melanogaster

-

function in protein repair

485612

-

485612

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Drosophila melanogaster

Q27869

the enzyme catalyzes the methylation of L-isoaspartyl residues that arise spontaneously in proteins with age, thereby initiating a repair process that restores the normal backbone configuration to the damaged polypeptide

657965

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Drosophila sp. (in: flies)

-

repairs abnormal aspartyl residues accumulated in vivo in type-I collagen and restores cell migration

658659

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Escherichia coli

-

-

485594

-

485594

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Escherichia coli

-

-

485596

-

485596

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Escherichia coli

-

-

485598

-

485598

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Escherichia coli

-

-

485600

-

485600

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Escherichia coli

-

-

485606

-

485606

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Escherichia coli

-

-

485607

-

485607

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Escherichia coli

-

-

485610

-

485610

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Escherichia coli

-

-

485611

-

485611

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Escherichia coli

-

-

485614

-

485614

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Escherichia coli

-

-

485615

-

485615

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Escherichia coli

-

-

485618

-

485618

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Escherichia coli

-

-

485622

-

485622

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Escherichia coli

-

repair and/or degradation of spontaneously damaged proteins

485598

-

485598

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Escherichia coli

-

the enzyme can stimulate repair of isoaspartyl residues arising spontaneously in proteins to normal L-aspartyl residues. Protein repair by the enzyme plays a key role in long-term stress survival only at alkaline pH in Escherichia coli, and it may function primarily to repair damage in cells that are recovering from nutrient limitation and those cells that are able to divide during long-term stationary phase

659896

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Escherichia coli

-

the enzyme might by overburdened in some physiological conditions and its overproduction may be beneficial in conditions in which protein aggregation occrus, for example during biotechnological protein overproduction or in protein aggregation diseases

659061

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Escherichia coli

-

the enzyme prevents the accumulation of deaminated proteins

659291

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Escherichia coli

-

the enzyme might by overburdened in some physiological conditions and its overproduction may be beneficial in conditions in which protein aggregation occurs, for example during biotechnological protein overproduction or in protein aggregation diseases

659061

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Gallus gallus

-

-

485605

-

485605

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Gallus gallus

-

-

485608

-

485608

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Homo sapiens

-

-

485591

-

485591

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Homo sapiens

-

-

485593

-

485593

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Homo sapiens

-

-

485594

-

485594

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Homo sapiens

-

-

485595

-

485595

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Homo sapiens

-

-

485596

-

485596

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Homo sapiens

-

-

485597

-

485597

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Homo sapiens

-

-

485598

-

485598

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Homo sapiens

-

-

485600

-

485600

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Homo sapiens

-

-

485604

-

485604

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Homo sapiens

-

-

485605

-

485605

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Homo sapiens

-

-

485607

-

485607

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Homo sapiens

-

-

485610

-

485610

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Homo sapiens

-

-

485611

-

485611

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Homo sapiens

-

-

485613

-

485613

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Homo sapiens

-

-

485614

-

485614

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Homo sapiens

-

-

485615

-

485615

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Homo sapiens

-

-

485617

-

485617

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Homo sapiens

-

-

485618

-

485618

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Homo sapiens

-

-

485620

-

485620

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Homo sapiens

-

-

485621

-

485621

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Homo sapiens

-

-

485622

-

485622

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Homo sapiens

-

-

701664, 701684, 702014, 702015, 703773, 706709, 733125, 733251, 733992, 735263, 755789, 756673, 756674, 756902, 757656, 757812, 758169

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Homo sapiens

P22061

-

706585, 734535

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Homo sapiens

-

-

734535

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Homo sapiens

-

involved in the repair of age-damaged proteins, aspartyl and asparginyl residues that are susceptible to deamidation, isomerization and racemization

485613

-

485613

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Homo sapiens

-

repair enzyme that acts upon damaged proteins bearing abnormal aspartyl residues

659913

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Homo sapiens

-

PCMT catalyzes methyl esterification of the free alpha-carboxyl group at the isoaspartyl site, thus initiating the repair of the abnormal protein through the conversion of the isopeptide bond into a normal alpha-peptide bond

706415

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Limax maximus

-

-

485601

-

485601

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Limax maximus

-

implicated in the repair or degradation of age-damaged proteins that contain atypical L-isoaspartyl residues

485601

-

485601

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Methanocaldococcus jannaschii

-

-

485610

-

485610

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Methanothermobacter thermautotrophicus

-

-

485610

-

485610

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Mus musculus

-

-

485592

-

485592

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Mus musculus

-

-

485600

-

485600

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Mus musculus

-

-

485607

-

485607

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Mus musculus

-

-

485610

-

485610

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Mus musculus

-

-

485613

-

485613

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Mus musculus

-

-

485614

-

485614

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Mus musculus

-

-

485617

-

485617

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Mus musculus

-

-

485619

-

485619

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Mus musculus

-

-

485622

-

485622

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Mus musculus

-

-

735062

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Mus musculus

-

key role in degradation or repair of deamination damaged proteins

485592

-

485592

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Oryctolagus cuniculus

-

-

485595

-

485595

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Oryctolagus cuniculus

-

-

485600

-

485600

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Oryctolagus cuniculus

-

-

485605

-

485605

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Oryza sativa

-

-

485615

-

485615

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Oryza sativa

-

-

485618

-

485618

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Oryza sativa

-

-

734934, 757817

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Oryza sativa M-101

-

-

485618

-

485618

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Pyrococcus furiosus

-

-

485622

-

485622

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Pyrococcus furiosus

Q8TZR3

-

485616

-

485616

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Pyrococcus furiosus

Q8TZR3

protein repair methyltransferase

485616

-

485616

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Rattus norvegicus

-

-

485592

-

485592

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Rattus norvegicus

-

-

485595

-

485595

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Rattus norvegicus

-

-

485596

-

485596

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Rattus norvegicus

-

-

485600

-

485600

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Rattus norvegicus

-

-

485605

-

485605

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Rattus norvegicus

-

-

485606

-

485606

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Rattus norvegicus

-

-

485609

-

485609

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Rattus norvegicus

-

-

485610

-

485610

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Rattus norvegicus

-

-

485612

-

485612

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Rattus norvegicus

-

-

485615

-

485615

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Rattus norvegicus

-

-

485619

-

485619

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Rattus norvegicus

-

-

756096, 756282

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Rattus norvegicus

-

-

485599

-

485599

r

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Rattus norvegicus

-

post-translational covalent modification

485599

-

-

r

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Rattus norvegicus

-

key role in degradation or repair of deamination damaged proteins

485592

-

485592

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Rattus norvegicus Sprague-Dawley

-

-

485599

-

485599

r

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Rattus norvegicus Sprague-Dawley

-

post-translational covalent modification

485599

-

-

r

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Rattus norvegicus Sprague-Dawley

-

-

485605

-

485605

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Rhodopseudomonas palustris

-

-

757230

-

-

ir

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Salmonella enterica subsp. enterica

-

-

756543, 756792, 756978

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Salmonella enterica subsp. enterica E-2375

-

-

756978

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Salmonella enterica subsp. enterica E-5591

-

-

756792

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

485592

-

485592

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

485594

-

485594

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

485596

-

485596

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

485598

-

485598

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

485600

-

485600

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Salmonella enterica subsp. enterica serovar Typhimurium

-

key role in degradation or repair of deamination damaged proteins

485592

-

485592

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Solanum lycopersicum

-

-

485615

-

485615

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Thermotoga maritima

-

-

485610

-

485610

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Thermotoga maritima

-

-

485615

-

485615

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Thermotoga maritima

-

-

485621

-

485621

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Thermotoga maritima

-

-

485622

-

485622

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Thermotoga maritima

-

highly active protein repair enzyme

485610

-

485610

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Torpedo ocellata

-

-

485595

-

485595

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Torpedo ocellata

-

-

485605

-

485605

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Triticum aestivum

-

-

485601

-

485601

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Triticum aestivum

-

-

485605

-

485605

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Triticum aestivum

-

-

485607

-

485607

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Triticum aestivum

-

-

485610

-

485610

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Triticum aestivum

-

-

485615

-

485615

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Triticum aestivum

-

-

485618

-

485618

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Triticum aestivum

-

implicated in the repair or degradation of age-damaged proteins that contain atypical L-isoaspartyl residues

485601

-

485601

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Vibrio cholerae serotype O1

-

-

733437

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Vibrio cholerae serotype O1

A5F9C1

-

755888

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Vibrio cholerae serotype O1 ATCC 39541

A5F9C1

-

755888

-

-

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Xenopus laevis

-

-

485592

-

485592

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Xenopus laevis

-

-

485595

-

485595

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Xenopus laevis

-

-

485605

-

485605

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Xenopus laevis

-

-

485615

-

485615

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Xenopus laevis

-

-

485617

-

485617

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Xenopus laevis

-

key role in degradation or repair of deamination damaged proteins

485592

-

485592

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Zea mays

-

-

485615

-

485615

?

S-adenosyl-L-methionine + protein L-isoaspartate

S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester

Zea mays

-

-

485618

-

485618

?

S-adenosyl-L-methionine + synapsin I

S-adenosyl-L-homocysteine + ?

Bos taurus

-

-

485597

-

-

?

S-adenosyl-L-methionine + synapsin I

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485597

-

-

?

S-adenosyl-L-methionine + VYP (isoD) HA

S-adenosyl-L-homocysteine + ?

Caenorhabditis elegans

-

-

485610

-

-

?

S-adenosyl-L-methionine + VYP (isoD) HA

S-adenosyl-L-homocysteine + ?

Escherichia coli

-

-

485610

-

-

?

S-adenosyl-L-methionine + VYP (isoD) HA

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485610

-

-

?

S-adenosyl-L-methionine + VYP (isoD) HA

S-adenosyl-L-homocysteine + ?

Thermotoga maritima

-

-

485610

-

-

?

S-adenosyl-L-methionine + VYP (isoD) HA

S-adenosyl-L-homocysteine + ?

Triticum aestivum

-

-

485610

-

-

?

S-adenosyl-L-methionine + VYP(L-isoaspartate)HA

S-adenosyl-L-homocysteine + VYP(L-isoaspartate alpha-methyl ester)HA

Vibrio cholerae serotype O1

A5F9C1

-

755888

-

-

?

S-adenosyl-L-methionine + VYP(L-isoaspartate)HA

S-adenosyl-L-homocysteine + VYP(L-isoaspartate alpha-methyl ester)HA

Vibrio cholerae serotype O1 ATCC 39541

A5F9C1

-

755888

-

-

?

S-adenosyl-L-methionine + VYP-(L-iso-Asp)-HA

S-adenosyl-L-homocysteine + VYP-(L-iso-Asp-alpha-methyl ester)-HA

Arabidopsis thaliana

-

-

757241

-

-

?

S-adenosyl-L-methionine + VYP-(L-iso-Asp)-HA

S-adenosyl-L-homocysteine + VYP-(L-iso-Asp-alpha-methyl ester)-HA

Oryza sativa

-

-

757817

-

-

?

S-adenosyl-L-methionine + VYP-isoD-GA

S-adenosyl-L-homocysteine + ?

Bos taurus

-

-

485597

-

-

?

S-adenosyl-L-methionine + VYP-isoD-GA

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485597

-

-

?

S-adenosyl-L-methionine + VYP-L-isoAsp-HA

S-adenosyl-L-homocysteine + ?

Arabidopsis thaliana

-

-

485615, 485618, 485622

-

-

?

S-adenosyl-L-methionine + VYP-L-isoAsp-HA

S-adenosyl-L-homocysteine + ?

Homo sapiens

-

-

485615, 485618, 485622

-

-

?

S-adenosyl-L-methionine + VYP-L-isoAsp-HA

S-adenosyl-L-homocysteine + ?

Oryza sativa

-

-

485615, 485618

-

-

?

S-adenosyl-L-methionine + VYP-L-isoAsp-HA

S-adenosyl-L-homocysteine + ?

Oryza sativa M-101

-

-

485618

-

-

?

S-adenosyl-L-methionine + VYP-L-isoAsp-HA

S-adenosyl-L-homocysteine + ?

Pyrococcus furiosus

-

-

485622

-

-

?

S-adenosyl-L-methionine + VYP-L-isoAsp-HA

S-adenosyl-L-homocysteine + ?

Triticum aestivum

-

-

485615, 485618

-

-

?

S-adenosyl-L-methionine + VYP-L-isoAsp-HA

S-adenosyl-L-homocysteine + ?

Zea mays

-

-

485615, 485618

-

-

?

additional information

?

-

Bos taurus

-

PIMT level is downregulated by proteasomal degradation, involving the PI3K pathway, during cell attachment. The regulation of PIMT level upon cell-substratum contact suggests a potential role for PIMT in biological processes such as wound healing, cell migration, and tumor metastasis dissemination

671815

-

-

?

additional information

?

-

Homo sapiens

-

-

485622

-

-

?

additional information

?

-

Homo sapiens

-

native E. coli histidine phosphocarrier protein is no substrate

485604

-

-

?

additional information

?

-

Homo sapiens

P22061

protein L-Asp and protein D-isoaspartate are no substrates

734535

-

-

?

additional information

?

-

Homo sapiens

-

protein L-Asp and protein D-isoaspartate are no substrates

734535

-

-

?

additional information

?

-

Homo sapiens

P22061

no activity with VYP-D-beta-Asp-GA and VYP-L-alpha-Asp-GA

734535

-

-

?

additional information

?

-

Homo sapiens

-

no activity with VYP-D-beta-Asp-GA and VYP-L-alpha-Asp-GA

734535

-

-

?

additional information

?

-

Pyrococcus furiosus

-

O-succinyl-L-homoserine, succinyl choline chloride, succinyl acetone, succinic acid and succinamic acid are no substrates

485622

-

-

?