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2.1.1.77: protein-L-isoaspartate(D-aspartate) O-methyltransferase

This is an abbreviated version!
For detailed information about protein-L-isoaspartate(D-aspartate) O-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.77

Reaction

S-adenosyl-L-methionine
+
protein L-isoaspartate
=
S-adenosyl-L-homocysteine
 +
protein L-isoaspartate alpha-methyl ester

Synonyms

chaperone protein L-isoaspartate (D-aspartyl) O-methyltransferase, D-aspartyl/L-isoaspartyl methyltransferase, EC 2.1.1.24, HPIMT, IAMT, isoaspartyl peptide methyltransferase, isoaspartyl protein carboxyl-O-methyltransferase, L-aspartyl/L-isoaspartyl protein methyltransferase, L-IAMT, L-isoaspartate O-methyltransferase, L-isoaspartyl (D-aspartyl) methyltransferase, L-isoaspartyl (D-aspartyl) O-methyltransferase, L-isoaspartyl methyltransferase, L-isoaspartyl O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, L-isoaspartyl-O-methyltransferase, L-isoaspartyl/D-aspartyl O-methyltransferase, L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase, methyltransferase, protein (D-aspartate), PCM, PCM-1, PCMT, PCMT1, PIMT, PIMT1, PIMT2, PIMT2 TISIalphaomega, PIMT2 TISIalphapsi, PIMT2 TISIbetapsi, PIMT2 TISIIalphaomega, PIMT2 TISIIalphapsi, PIMT2 TISIIbetapsi, PIMT2 TISIIIalphaomega, PIMT2 TISIIIalphapsi, PIMT2 TISIIIbetapsi, PIMT2', protein (L-isoaspartate) O-methyltransferase, protein carboxyl methyltransferase type II, protein D-aspartate methyltransferase, protein isoaspartate methyl transferase, protein isoaspartate methyltransferase, protein isoaspartyl carboxyl O-methyltransferase, protein isoaspartyl methyltransferase, protein isoaspartyl methyltransferase 1, protein L-isoaspartate (D-aspartate) O-methyltransferase, protein L-isoaspartate methyltransferase, protein L-isoaspartate O-methyltransferase, protein L-isoaspartate-O-methyltransferase, protein L-isoaspartyl (D-aspartate) O-methyltransferase, protein L-isoaspartyl (D-aspartyl) methyltransferase, protein L-isoaspartyl (D-aspartyl) O-methyltransferase, protein L-isoaspartyl methyl transferase, protein L-isoaspartyl methyltransferase, protein L-isoaspartyl methyltransferase1, protein L-isoaspartyl methyltransferase2, protein L-isoaspartyl O-methyltransferase, protein L-isoaspartyl-O-methyltransferase, protein L-isoaspartyl/D-aspartyl O-methyltransferase, protein repair L-isoaspartyl methyltransferase, protein repair L-isoaspartyl methyltransferase 1, protein-beta-aspartate O-methyltransferase, protein-L-isoaspartate (D-aspartate) O-methyltransferase, protein-L-isoaspartate methyltransferase, protein-L-isoaspartate O-methyltransferase, protein-L-isoaspartyl methyltransferase, RPA0376, RPA2838, StoPIMT, type II methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.77 protein-L-isoaspartate(D-aspartate) O-methyltransferase

Expression

Expression on EC 2.1.1.77 - protein-L-isoaspartate(D-aspartate) O-methyltransferase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
1-chloro-2,4-dinitrobenzene does not affect PIMT expression
-
5 mM valproic acid enhances protein L-isoaspartyl methyltransferase expression about 2fold through glycogen synthase kinase-3/beta-catenin requires 90 kDa ribosomal S6 kinase. Src, c-Raf, MEK1/2 and extracellular-regulated kinase 1/2 abolish the extracellular-regulated kinase 1/2 phosphorylation stimulated by valproic acid, thus preventing PIMT induction by valproic acid
-
CGP3466B upregulates enzyme expression
-
down-regulation of PIMT by siRNA strikingly enhances phenylarsine oxide-induced reactive oxygen species
-
enzyme activity and expression are 50% lower in the hippocampus of epileptic patients
-
enzyme activity gradually increases as seed development proceeds, with maximum activity during maturation drying. The enzyme activity is also stimulated in the presence of various phytohormones, especially abscisic acid
-
enzyme expression decreases sharply as the seed undergoes dehydration
-
enzyme expression is down-regulated at both gene and protein levels by cytosolic dopamine in SH-SY5Y cells
-
heat and oxidative stress treatments strongly induce PIMT1 and PIMT2 transcript expression
-
isoform PIMT1 transcript accumulation is significantly greater in abscisic acid-treated seedlings than in the control
isoform PIMT2 transcript accumulates about 4fold more relative to the control under environmental stress conditions like treatment with polyethylene glycol, 200 mM sodium chloride or 0.0005 mM paraquat. Isoform PIMT2 transcript accumulation is significantly greater in abscisic acid-treated seedlings than in the control
pcm-1 dauer and dauer-like larvae display an average of 46% decrease in lifespan in comparison to N2 dauer and dauer-like larvae
-
PIMT is about 2fold up-regulated by 0.005 mM phenylarsine oxide in U-87 human astroglioma cells, PIMT up-regulation by phenylarsine oxide is mediated by the reaction with vicinal cysteines, PIMT induction by phenylarsine oxide is dependent on formation of reactive oxygen species, PIMT induction by phenylarsine oxide is inhibited by N-acetyl-L-cysteine and diphenyleneiodonium chloride
-
PIMT is slightly up-regulated by 0.01 mM cycloheximide
-
temperature (42 °C) induces elevation in enzyme expression level
-
the activity is elevated about 3fold towards high temperature, cold, salt, dehydration, and oxidative stress induced by paraquat, as well as high pH conditions
the enzyme expression is increased in patients with advanced stages of lung adenocarcinoma
-
there is a 3.5fold induction of enzyme expression following exposure to 42°C
upon heat shock and dauer formation-inducing conditions, there is additional pcm-1 expression in body wall muscle nuclei and actomyosin filaments and in hypodermal cells
-