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Literature summary for 2.1.1.77 extracted from

  • Thapar, N.; Griffith, S.C.; Yeates, T.O.; Clarke, S.
    Protein repair methyltransferase from the hyperthermophilic archaeon Pyrococcus furiosus: unusual methyl-accepting affinity for D-aspartyl and N-succinyl-containing peptides (2002), J. Biol. Chem., 277, 1058-1065.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
cloned and expressed in Escherichia coli TOP10 Pyrococcus furiosus

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Pyrococcus furiosus

Inhibitors

Inhibitors Comment Organism Structure
5'-deoxy-5'-methylthioadenosine
-
Homo sapiens
5'-deoxy-5'-methylthioadenosine
-
Pyrococcus furiosus
adenosine
-
Pyrococcus furiosus
S-adenosylhomocysteine
-
Homo sapiens
S-adenosylhomocysteine potent inhibitor at pH 4 and 7.5 Pyrococcus furiosus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00026
-
KASA (isoAsp) LAKY 68°C, pH 7.5 Pyrococcus furiosus
0.00029
-
VYP-L-isoAsp-HA 37°C, pH 7.5 Homo sapiens
0.00052
-
KASA (isoAsp) LAKY
-
Homo sapiens
0.00053
-
VYP-L-isoAsp-HA 68°C, pH 7.5 Pyrococcus furiosus
0.00055
-
KASA (isoAsp) LAKY
-
Pyrococcus furiosus
0.00059
-
VYP-L-isoAsp-HA 37°C, pH 7.5 Pyrococcus furiosus
0.0022
-
S-adenosyl-L-methionine
-
Homo sapiens
0.00341
-
S-adenosyl-L-methionine 68°C, pH 7.5 Pyrococcus furiosus
0.00463
-
ovalbumin 68°C, pH 7.5 Pyrococcus furiosus
0.008
-
VYP-L-isoAsp-HA 68°C, pH 4 Pyrococcus furiosus
0.021
-
KASA (isoAsp) LAKY 68°C, pH 4.0 Pyrococcus furiosus
0.023
-
KASA (D-Asp) LAKY
-
Pyrococcus furiosus
0.035
-
ovalbumin
-
Homo sapiens
0.166
-
ovalbumin
-
Pyrococcus furiosus
0.375
-
N-succinyl-AAVAp-nitroanilide 68°C, pH 7.5 Pyrococcus furiosus
0.69
-
N-succinyl-AAVAp-nitroanilide
-
Homo sapiens
2.7
-
KASA (D-Asp) LAKY
-
Homo sapiens
11
-
N-succinyl-AAVAp-nitroanilide 68°C, pH 4.0 Pyrococcus furiosus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + protein L-isoaspartate Mus musculus
-
S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
?
S-adenosyl-L-methionine + protein L-isoaspartate Escherichia coli
-
S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
?
S-adenosyl-L-methionine + protein L-isoaspartate Homo sapiens
-
S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
?
S-adenosyl-L-methionine + protein L-isoaspartate Arabidopsis thaliana
-
S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
?
S-adenosyl-L-methionine + protein L-isoaspartate Pyrococcus furiosus
-
S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
?
S-adenosyl-L-methionine + protein L-isoaspartate Caenorhabditis elegans
-
S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
?
S-adenosyl-L-methionine + protein L-isoaspartate Thermotoga maritima
-
S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
Thale cress
-
Caenorhabditis elegans
-
-
-
Escherichia coli
-
-
-
Homo sapiens
-
human
-
Mus musculus
-
-
-
Pyrococcus furiosus
-
-
-
Thermotoga maritima
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant protein Pyrococcus furiosus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information
-
Homo sapiens ?
-
?
additional information O-succinyl-L-homoserine, succinyl choline chloride, succinyl acetone, succinic acid and succinamic acid are no substrates Pyrococcus furiosus ?
-
?
S-adenosyl-L-methionine + KASA (D-Asp) LAKY
-
Homo sapiens S-adenosyl-L-homocysteine + ?
-
?
S-adenosyl-L-methionine + KASA (D-Asp) LAKY
-
Pyrococcus furiosus S-adenosyl-L-homocysteine + ?
-
?
S-adenosyl-L-methionine + KASA-L-isoAsp-LAKY
-
Homo sapiens S-adenosyl-L-homocysteine + ?
-
?
S-adenosyl-L-methionine + KASA-L-isoAsp-LAKY
-
Arabidopsis thaliana S-adenosyl-L-homocysteine + ?
-
?
S-adenosyl-L-methionine + KASA-L-isoAsp-LAKY
-
Pyrococcus furiosus S-adenosyl-L-homocysteine + ?
-
?
S-adenosyl-L-methionine + N-succinyl-AAA-p-nitroanilide
-
Pyrococcus furiosus S-adenosyl-L-homocysteine + ?
-
?
S-adenosyl-L-methionine + N-succinyl-AAPF-p-nitroanilide
-
Pyrococcus furiosus S-adenosyl-L-homocysteine + ?
-
?
S-adenosyl-L-methionine + N-succinyl-AAPL-p-nitroanilide
-
Pyrococcus furiosus S-adenosyl-L-homocysteine + ?
-
?
S-adenosyl-L-methionine + N-succinyl-AAV-p-nitroanilide
-
Pyrococcus furiosus S-adenosyl-L-homocysteine + ?
-
?
S-adenosyl-L-methionine + N-succinyl-AAVA-p-nitroanilide
-
Homo sapiens S-adenosyl-L-homocysteine + ?
-
?
S-adenosyl-L-methionine + N-succinyl-AAVA-p-nitroanilide
-
Pyrococcus furiosus S-adenosyl-L-homocysteine + ?
-
?
S-adenosyl-L-methionine + ovalbumin
-
Escherichia coli S-adenosyl-L-homocysteine + ?
-
?
S-adenosyl-L-methionine + ovalbumin
-
Homo sapiens S-adenosyl-L-homocysteine + ?
-
?
S-adenosyl-L-methionine + ovalbumin
-
Arabidopsis thaliana S-adenosyl-L-homocysteine + ?
-
?
S-adenosyl-L-methionine + ovalbumin
-
Pyrococcus furiosus S-adenosyl-L-homocysteine + ?
-
?
S-adenosyl-L-methionine + ovalbumin
-
Caenorhabditis elegans S-adenosyl-L-homocysteine + ?
-
?
S-adenosyl-L-methionine + ovalbumin
-
Thermotoga maritima S-adenosyl-L-homocysteine + ?
-
?
S-adenosyl-L-methionine + protein D-aspartate
-
Escherichia coli S-adenosyl-L-homocysteine + protein D-aspartate beta-methyl ester
-
?
S-adenosyl-L-methionine + protein D-aspartate
-
Homo sapiens S-adenosyl-L-homocysteine + protein D-aspartate beta-methyl ester
-
?
S-adenosyl-L-methionine + protein D-aspartate
-
Arabidopsis thaliana S-adenosyl-L-homocysteine + protein D-aspartate beta-methyl ester
-
?
S-adenosyl-L-methionine + protein D-aspartate
-
Pyrococcus furiosus S-adenosyl-L-homocysteine + protein D-aspartate beta-methyl ester
-
?
S-adenosyl-L-methionine + protein L-isoaspartate
-
Mus musculus S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
?
S-adenosyl-L-methionine + protein L-isoaspartate
-
Escherichia coli S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
?
S-adenosyl-L-methionine + protein L-isoaspartate
-
Homo sapiens S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
?
S-adenosyl-L-methionine + protein L-isoaspartate
-
Arabidopsis thaliana S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
?
S-adenosyl-L-methionine + protein L-isoaspartate
-
Pyrococcus furiosus S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
?
S-adenosyl-L-methionine + protein L-isoaspartate
-
Caenorhabditis elegans S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
?
S-adenosyl-L-methionine + protein L-isoaspartate
-
Thermotoga maritima S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
?
S-adenosyl-L-methionine + succinamide
-
Pyrococcus furiosus S-adenosyl-L-homocysteine + ?
-
?
S-adenosyl-L-methionine + VYP-L-isoAsp-HA
-
Homo sapiens S-adenosyl-L-homocysteine + ?
-
?
S-adenosyl-L-methionine + VYP-L-isoAsp-HA
-
Arabidopsis thaliana S-adenosyl-L-homocysteine + ?
-
?
S-adenosyl-L-methionine + VYP-L-isoAsp-HA
-
Pyrococcus furiosus S-adenosyl-L-homocysteine + ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
45 55
-
Arabidopsis thaliana
45 55
-
Pyrococcus furiosus
85
-
-
Pyrococcus furiosus
85
-
-
Thermotoga maritima

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
4 95
-
Pyrococcus furiosus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
85 95 little or no loss of activity Pyrococcus furiosus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4
-
-
Pyrococcus furiosus

pH Range

pH Minimum pH Maximum Comment Organism
3 10
-
Arabidopsis thaliana
3 10
-
Pyrococcus furiosus

Cofactor

Cofactor Comment Organism Structure
adenosine tightly bound cofactor Pyrococcus furiosus
S-adenosyl-L-homocysteine tightly bound cofactor Homo sapiens
S-adenosyl-L-homocysteine tightly bound cofactor Pyrococcus furiosus
S-adenosyl-L-methionine
-
Pyrococcus furiosus