Cloned (Comment) | Organism |
---|---|
cloned and expressed in Escherichia coli TOP10 | Pyrococcus furiosus |
Crystallization (Comment) | Organism |
---|---|
- |
Pyrococcus furiosus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5'-deoxy-5'-methylthioadenosine | - |
Homo sapiens | |
5'-deoxy-5'-methylthioadenosine | - |
Pyrococcus furiosus | |
adenosine | - |
Pyrococcus furiosus | |
S-adenosylhomocysteine | - |
Homo sapiens | |
S-adenosylhomocysteine | potent inhibitor at pH 4 and 7.5 | Pyrococcus furiosus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00026 | - |
KASA (isoAsp) LAKY | 68°C, pH 7.5 | Pyrococcus furiosus | |
0.00029 | - |
VYP-L-isoAsp-HA | 37°C, pH 7.5 | Homo sapiens | |
0.00052 | - |
KASA (isoAsp) LAKY | - |
Homo sapiens | |
0.00053 | - |
VYP-L-isoAsp-HA | 68°C, pH 7.5 | Pyrococcus furiosus | |
0.00055 | - |
KASA (isoAsp) LAKY | - |
Pyrococcus furiosus | |
0.00059 | - |
VYP-L-isoAsp-HA | 37°C, pH 7.5 | Pyrococcus furiosus | |
0.0022 | - |
S-adenosyl-L-methionine | - |
Homo sapiens | |
0.00341 | - |
S-adenosyl-L-methionine | 68°C, pH 7.5 | Pyrococcus furiosus | |
0.00463 | - |
ovalbumin | 68°C, pH 7.5 | Pyrococcus furiosus | |
0.008 | - |
VYP-L-isoAsp-HA | 68°C, pH 4 | Pyrococcus furiosus | |
0.021 | - |
KASA (isoAsp) LAKY | 68°C, pH 4.0 | Pyrococcus furiosus | |
0.023 | - |
KASA (D-Asp) LAKY | - |
Pyrococcus furiosus | |
0.035 | - |
ovalbumin | - |
Homo sapiens | |
0.166 | - |
ovalbumin | - |
Pyrococcus furiosus | |
0.375 | - |
N-succinyl-AAVAp-nitroanilide | 68°C, pH 7.5 | Pyrococcus furiosus | |
0.69 | - |
N-succinyl-AAVAp-nitroanilide | - |
Homo sapiens | |
2.7 | - |
KASA (D-Asp) LAKY | - |
Homo sapiens | |
11 | - |
N-succinyl-AAVAp-nitroanilide | 68°C, pH 4.0 | Pyrococcus furiosus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + protein L-isoaspartate | Mus musculus | - |
S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
S-adenosyl-L-methionine + protein L-isoaspartate | Escherichia coli | - |
S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
S-adenosyl-L-methionine + protein L-isoaspartate | Homo sapiens | - |
S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
S-adenosyl-L-methionine + protein L-isoaspartate | Arabidopsis thaliana | - |
S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
S-adenosyl-L-methionine + protein L-isoaspartate | Pyrococcus furiosus | - |
S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
S-adenosyl-L-methionine + protein L-isoaspartate | Caenorhabditis elegans | - |
S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
S-adenosyl-L-methionine + protein L-isoaspartate | Thermotoga maritima | - |
S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | - |
Thale cress | - |
Caenorhabditis elegans | - |
- |
- |
Escherichia coli | - |
- |
- |
Homo sapiens | - |
human | - |
Mus musculus | - |
- |
- |
Pyrococcus furiosus | - |
- |
- |
Thermotoga maritima | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant protein | Pyrococcus furiosus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | - |
Homo sapiens | ? | - |
? | |
additional information | O-succinyl-L-homoserine, succinyl choline chloride, succinyl acetone, succinic acid and succinamic acid are no substrates | Pyrococcus furiosus | ? | - |
? | |
S-adenosyl-L-methionine + KASA (D-Asp) LAKY | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + KASA (D-Asp) LAKY | - |
Pyrococcus furiosus | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + KASA-L-isoAsp-LAKY | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + KASA-L-isoAsp-LAKY | - |
Arabidopsis thaliana | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + KASA-L-isoAsp-LAKY | - |
Pyrococcus furiosus | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + N-succinyl-AAA-p-nitroanilide | - |
Pyrococcus furiosus | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + N-succinyl-AAPF-p-nitroanilide | - |
Pyrococcus furiosus | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + N-succinyl-AAPL-p-nitroanilide | - |
Pyrococcus furiosus | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + N-succinyl-AAV-p-nitroanilide | - |
Pyrococcus furiosus | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + N-succinyl-AAVA-p-nitroanilide | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + N-succinyl-AAVA-p-nitroanilide | - |
Pyrococcus furiosus | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + ovalbumin | - |
Escherichia coli | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + ovalbumin | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + ovalbumin | - |
Arabidopsis thaliana | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + ovalbumin | - |
Pyrococcus furiosus | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + ovalbumin | - |
Caenorhabditis elegans | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + ovalbumin | - |
Thermotoga maritima | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + protein D-aspartate | - |
Escherichia coli | S-adenosyl-L-homocysteine + protein D-aspartate beta-methyl ester | - |
? | |
S-adenosyl-L-methionine + protein D-aspartate | - |
Homo sapiens | S-adenosyl-L-homocysteine + protein D-aspartate beta-methyl ester | - |
? | |
S-adenosyl-L-methionine + protein D-aspartate | - |
Arabidopsis thaliana | S-adenosyl-L-homocysteine + protein D-aspartate beta-methyl ester | - |
? | |
S-adenosyl-L-methionine + protein D-aspartate | - |
Pyrococcus furiosus | S-adenosyl-L-homocysteine + protein D-aspartate beta-methyl ester | - |
? | |
S-adenosyl-L-methionine + protein L-isoaspartate | - |
Mus musculus | S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
S-adenosyl-L-methionine + protein L-isoaspartate | - |
Escherichia coli | S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
S-adenosyl-L-methionine + protein L-isoaspartate | - |
Homo sapiens | S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
S-adenosyl-L-methionine + protein L-isoaspartate | - |
Arabidopsis thaliana | S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
S-adenosyl-L-methionine + protein L-isoaspartate | - |
Pyrococcus furiosus | S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
S-adenosyl-L-methionine + protein L-isoaspartate | - |
Caenorhabditis elegans | S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
S-adenosyl-L-methionine + protein L-isoaspartate | - |
Thermotoga maritima | S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
S-adenosyl-L-methionine + succinamide | - |
Pyrococcus furiosus | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + VYP-L-isoAsp-HA | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + VYP-L-isoAsp-HA | - |
Arabidopsis thaliana | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + VYP-L-isoAsp-HA | - |
Pyrococcus furiosus | S-adenosyl-L-homocysteine + ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
45 | 55 | - |
Arabidopsis thaliana |
45 | 55 | - |
Pyrococcus furiosus |
85 | - |
- |
Pyrococcus furiosus |
85 | - |
- |
Thermotoga maritima |
Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|
4 | 95 | - |
Pyrococcus furiosus |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
85 | 95 | little or no loss of activity | Pyrococcus furiosus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4 | - |
- |
Pyrococcus furiosus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
3 | 10 | - |
Arabidopsis thaliana |
3 | 10 | - |
Pyrococcus furiosus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
adenosine | tightly bound cofactor | Pyrococcus furiosus | |
S-adenosyl-L-homocysteine | tightly bound cofactor | Homo sapiens | |
S-adenosyl-L-homocysteine | tightly bound cofactor | Pyrococcus furiosus | |
S-adenosyl-L-methionine | - |
Pyrococcus furiosus |