1.21.99.4: thyroxine 5'-deiodinase
This is an abbreviated version!
For detailed information about thyroxine 5'-deiodinase, go to the full flat file.
Word Map on EC 1.21.99.4
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1.21.99.4
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thyroid
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triiodothyronine
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hypothyroidism
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tsh
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deiodination
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adipose
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pituitary
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selenium
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euthyroidism
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selenoproteins
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3,5,3'-triiodothyronine
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thyrotropin
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prohormone
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thermogenesis
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selenoenzyme
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propylthiouracil
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photoperiodic
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hypothalamic
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hypothalamic-pituitary-thyroid
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selenocysteine
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thyroid-stimulating
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thyrotropin-releasing
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iopanoic
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thermogenic
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iodotyrosine
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hypophysiotropic
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t3-dependent
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polybrominated
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extrathyroidal
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hypothyroxinemia
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3,3',5-triiodothyronine
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thyroxine-binding
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mediobasal
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pbdes
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5'-deiodination
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iodine-deficient
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tanycytes
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tuberalis
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debromination
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selenocysteine-containing
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trbeta
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methimazole
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thyrotoxicosis
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hormone-activating
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thyroperoxidase
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monocarboxylate
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nonthyroidal
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secis
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levothyroxine
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medicine
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selenium-deficient
- 1.21.99.4
- thyroid
- triiodothyronine
- hypothyroidism
- tsh
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deiodination
- adipose
- pituitary
- selenium
-
euthyroidism
-
selenoproteins
- 3,5,3'-triiodothyronine
- thyrotropin
-
prohormone
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thermogenesis
-
selenoenzyme
- propylthiouracil
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photoperiodic
- hypothalamic
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hypothalamic-pituitary-thyroid
- selenocysteine
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thyroid-stimulating
-
thyrotropin-releasing
-
iopanoic
-
thermogenic
- iodotyrosine
-
hypophysiotropic
-
t3-dependent
-
polybrominated
-
extrathyroidal
-
hypothyroxinemia
- 3,3',5-triiodothyronine
-
thyroxine-binding
-
mediobasal
-
pbdes
-
5'-deiodination
-
iodine-deficient
- tanycytes
- tuberalis
-
debromination
-
selenocysteine-containing
-
trbeta
- methimazole
- thyrotoxicosis
-
hormone-activating
- thyroperoxidase
-
monocarboxylate
-
nonthyroidal
-
secis
- levothyroxine
- medicine
-
selenium-deficient
Reaction
Synonyms
5DI
ECTree
1.21.99.4 thyroxine 5'-deiodinaseAdvanced search results
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results (Inhibitors
Inhibitors on EC 1.21.99.4 - thyroxine 5'-deiodinase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
(2E)-2-(3,4-dihydroxybenzylidene)-4,6-dihydroxy-1-benzofuran-3(2H)-one
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aurone derivative isolated from plant extract. Comparison with inhibition of 5-deiodinase EC 1.97.1.11
(2E)-2-(3,4-dihydroxybenzylidene)-6-hydroxy-1-benzofuran-3(2H)-one
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aurone derivative isolated from plant extract. Comparison with inhibition of 5-deiodinase EC 1.97.1.11
(2E)-4,6-dihydroxy-2-(4-hydroxy-3-iodobenzylidene)-1-benzofuran-3(2H)-one
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aurone derivative isolated from plant extract. Comparison with inhibition of 5-deiodinase EC 1.97.1.11
(2E)-4,6-dihydroxy-2-(4-hydroxybenzylidene)-1-benzofuran-3(2H)-one
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aurone derivative isolated from plant extract. Comparison with inhibition of 5-deiodinase EC 1.97.1.11
(4-[(E)-(4,6-dihydroxy-3-oxo-1-benzofuran-2(3H)-ylidene)methyl]phenoxy)acetic acid
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aurone derivative isolated from plant extract. Comparison with inhibition of 5-deiodinase EC 1.97.1.11
2-(3,4-dihydroxybenzyl)-4,6-dihydroxy-1-benzofuran-3(2H)-one
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aurone derivative isolated from plant extract. Comparison with inhibition of 5-deiodinase EC 1.97.1.11
2-amino-3-[4-[(4-hydroxy-3,5-diiodophenyl)thio]-3,5-diiodophenyl]propanoic acid
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comparison with 5-deiodinase EC 1.97.1.11
3,3',5,5'-tetraiodo-L-thyronine
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hypoxia has no effect on inhibition of T4
3,5,3'-triiodo-5'-nitrothyronine
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comparison with 5-deiodinase EC 1.97.1.11
3,5,5'-triiodo-2'-methylthyronine
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comparison with 5-deiodinase EC 1.97.1.11
3,5-diiodo-3',5'-dinitrothyronine
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comparison with 5-deiodinase EC 1.97.1.11
3,5-diiodo-4'-amino-3',5'-dimethylthyronine
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comparison with 5-deiodinase EC 1.97.1.11
ethyl 4-(4-hydroxy-3,5-diiodobenzoyl)phenyl carbonate
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comparison with 5-deiodinase EC 1.97.1.11
interleukin 1 and interleukin 6
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interleukins are competing for transcriptional coactivators and inhibit thyronine 5'-deiodinase induction by 3,3',5-triiodothyronine
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N-acetyl-3,5,3'-triiodo-5'-nitrothyronine
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comparison with 5-deiodinase EC 1.97.1.11
N-acetyl-3,5-diiodo-3',5'-dinitrothyronine
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comparison with 5-deiodinase EC 1.97.1.11
N-acetyl-3,5-diiodo-3'-bromo-5'-nitrothyronine
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comparison with 5-deiodinase EC 1.97.1.11
[4-(4-hydroxy-3,5-diiodophenoxy)phenyl]acetic acid
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comparison with 5-deiodinase EC 1.97.1.11
[4-(4-hydroxy-3,5-dinitrophenoxy)-3,5-diiodophenyl]acetic acid
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comparison with 5-deiodinase EC 1.97.1.11
[4-(4-hydroxy-3-iodo-5-nitrophenoxy)-3,5-diiodophenyl]acetic acid
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comparison with 5-deiodinase EC 1.97.1.11
[4-(4-hydroxy-3-iodo-5-nitrophenoxy)phenyl]acetic acid
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comparison with 5-deiodinase EC 1.97.1.11
6-Propyl-2-thiouracil
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inhibits selectively only thyronine 5'-deiodinase type I activity not type II activity
6-Propyl-2-thiouracil
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competes with thiol cofactor; type I mutant with exchange of selenocysteine by cystein is 300fold less sensitive
6-Propyl-2-thiouracil
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inhibits selectively only thyronine 5'-deiodinase type I activity not type II activity
6-Propyl-2-thiouracil
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inhibits selectively only thyronine 5'-deiodinase type I activity not type II activity
propylthiouracil
wild-type and mutant enzymes A131C and A131S are insensitive to propylthiouracil in presence ogf 20 mM dithiothreitol. When tested in presence of 0.2 mM dithiothreitol the Ic50 value for propylthiouracil is reduced to about 0.1 mM
additional information
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no inhibition by propylthiouracil, type II-like enzyme
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additional information
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expression and function of the 5-deiodinase and 5-deiodinase isozymes are sensitive to thyroid hormone status, various cytokines and growth factors, severe illness, reactive oxygen species, a variety of hormones and signaling compounds, circadian rythm, and pharmacological agents, and therefore might be useful in sensor function of physiology and pathophysiology
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additional information
substrate-induced loss of activity of the type 2 deiodinase is due to proteasomal degradation of the enzyme and requires interaction with the catalytic center
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additional information
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substrate-induced loss of activity of the type 2 deiodinase is due to proteasomal degradation of the enzyme and requires interaction with the catalytic center
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additional information
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the wild type enzyme is insensitive to 6-propyl-2-thiouracil
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additional information
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lipopolysaccharide-induced type 2 deiodinase activity is not inhibited by 1 mM 6-propyl-2-thiouracil
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additional information
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3,3',5'-triiodothyronine blocks 5'-deiodination of L-thyroxine blocks 5'-deiodination of 3,3',5'-triiodothyronine
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additional information
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L-thyroxine inhibited competitively 3,3',5'-triiodothyronine utilization of isoenzyme type II
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additional information
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3,3',5'-triiodothyronine blocks 5'-deiodination of L-thyroxine blocks 5'-deiodination of 3,3',5'-triiodothyronine
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additional information
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3,3',5'-triiodothyronine blocks 5'-deiodination of L-thyroxine blocks 5'-deiodination of 3,3',5'-triiodothyronine
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