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0.02
3,3',5'-triiodo-L-thyronine
-
pH 7.4, 37°C
0.0067 - 2.7
3,3',5'-triiodothyronine
0.0015 - 0.0045
3,3',5-triiodo-L-thyronine sulfate
0.00256 - 0.005
3,3',5-triiodothyronine
0.01
3,5'-diiodo-L-thyronine
-
pH 7.4, 37°C
0.003 - 0.57
L-3,5',3'-triiodothyronine
0.0000000017 - 0.009
L-thyroxine
0.00000101 - 0.015
reverse triiodothyronine
0.0007
sulfated reverse triiodothyronine
-
wild-type enzyme
0.00003 - 0.003
thyroxine
additional information
additional information
-
0.0067
3,3',5'-triiodothyronine
-
recombinant isoenzyme D2 (type II) from induced brain astrocytes with cosubstrate dithiothreitol KM: 18 mM
0.065
3,3',5'-triiodothyronine
-
DTT 10 mM
0.065
3,3',5'-triiodothyronine
-
type I, myocardial
0.1
3,3',5'-triiodothyronine
-
type I
0.1
3,3',5'-triiodothyronine
-
DTT 20 mM
0.18
3,3',5'-triiodothyronine
-
type I, liver
0.21
3,3',5'-triiodothyronine
-
type I
0.21
3,3',5'-triiodothyronine
-
DTT 10 mM
0.24
3,3',5'-triiodothyronine
-
DTT 10 mM
0.24
3,3',5'-triiodothyronine
-
type I, liver
0.25
3,3',5'-triiodothyronine
-
type I
0.25
3,3',5'-triiodothyronine
-
DTT 30 mM
0.28
3,3',5'-triiodothyronine
-
DTT 10 mM
0.28
3,3',5'-triiodothyronine
-
type I, liver
0.33
3,3',5'-triiodothyronine
-
DTT 10 mM
0.33
3,3',5'-triiodothyronine
-
type I, liver
0.51
3,3',5'-triiodothyronine
-
DTT 10 mM
0.51
3,3',5'-triiodothyronine
-
type I, liver
0.66
3,3',5'-triiodothyronine
-
DTT 10 mM
0.66
3,3',5'-triiodothyronine
-
type I,l iver
0.69
3,3',5'-triiodothyronine
-
DTT 10 mM
0.69
3,3',5'-triiodothyronine
-
type I, liver
0.7
3,3',5'-triiodothyronine
-
DTT 10 mM
0.7
3,3',5'-triiodothyronine
-
type I, liver
2.7
3,3',5'-triiodothyronine
-
type I mutant, exchange of selenocysteine by cysteine
0.0015
3,3',5-triiodo-L-thyronine sulfate
mutant enzyme G2A, duplicate determination give the values: 0.0015 mM and 0.0024 mM
0.0018
3,3',5-triiodo-L-thyronine sulfate
mutant enzyme N94Q
0.002
3,3',5-triiodo-L-thyronine sulfate
mutant enzyme S176A, duplicate determination give the values: 0.002 mM and 0.0024 mM
0.002
3,3',5-triiodo-L-thyronine sulfate
mutant enzyme S176A, duplicate determination give the values: 0.0024 mM and 0.0024 mM
0.002
3,3',5-triiodo-L-thyronine sulfate
mutant enzymes, in which selenocysteine residues in the core catalytic center is replaced by cysteine
0.0022
3,3',5-triiodo-L-thyronine sulfate
mutant enzyme S101A, duplicate determination give the values: 0.0022 mM and 3.2 mM
0.0024
3,3',5-triiodo-L-thyronine sulfate
mutant enzyme G2A, duplicate determination give the values: 0.0015 mM and 0.0024 mM
0.0028
3,3',5-triiodo-L-thyronine sulfate
native enzyme from rat liver microsomes
0.0029
3,3',5-triiodo-L-thyronine sulfate
mutant enzyme N94Q/N203Q
0.0032
3,3',5-triiodo-L-thyronine sulfate
mutant enzyme S101A, duplicate determination give the values: 0.0022 mM and 0.0032 mM
0.0045
3,3',5-triiodo-L-thyronine sulfate
mutant enzyme N203Q
0.00256
3,3',5-triiodothyronine
-
type I-like activity in kidney microsomes
0.005
3,3',5-triiodothyronine
-
type I-like activity in liver microsomes
0.003
L-3,5',3'-triiodothyronine
-
pH 7.4, 37°C, isozyme Dio2
0.57
L-3,5',3'-triiodothyronine
-
pH 7.4, 37°C, isozyme Dio1
0.0000000017
L-thyroxine
-
mutant P135S type 2 iodothyronine deiodinase, with 20 mM glutathione as cofactor, in Tris-EDTA buffer (pH 7.5), at 37°C
0.0000000029
L-thyroxine
-
wild type type 2 iodothyronine deiodinase, with 20 mM glutathione as cofactor, in Tris-EDTA buffer (pH 7.5), at 37°C
0.0000000059
L-thyroxine
-
wild type type 2 iodothyronine deiodinase, with 20 mM dithiothreitol as cofactor, in Tris-EDTA buffer (pH 7.5), at 37°C
0.000001
L-thyroxine
-
pH and temperature not specified in the publication
0.0000014
L-thyroxine
wild-type enzyme
0.0000023
L-thyroxine
-
neoplastic tissue, apparent Km
0.0000026
L-thyroxine
-
TT cell, apparent Km
0.0000045
L-thyroxine
mutant enzyme A131C, in presence of 20 mM dithiothreitol
0.0000045
L-thyroxine
-
mutant P135S type 2 iodothyronine deiodinase, with 20 mM dithiothreitol as cofactor, in Tris-EDTA buffer (pH 7.5), at 37°C
0.0000049
L-thyroxine
wild-type enzyme, in presence of 20 mM dithiothreitol
0.0000054
L-thyroxine
mutant enzyme A131S, in presence of 20 mM dithiothreitol
0.0002 - 0.0006
L-thyroxine
-
isoform III, 37°C, pH 6.0
0.001
L-thyroxine
-
isoform II, 37°C, pH 6.0
0.001 - 0.005
L-thyroxine
-
type II
0.002
L-thyroxine
-
pH 7.4, 37°C
0.002 - 0.0035
L-thyroxine
-
isoform I, 37°C, pH 6.8
0.0021
L-thyroxine
mutant enzyme SeC133C
0.005
L-thyroxine
mutant enzyme SeC133C, in presence of 20 mM dithiothreitol
0.0066
L-thyroxine
mutant enzyme SeC133C/A131C, in presence of 20 mM dithiothreitol
0.009
L-thyroxine
-
DTT 20 mM
0.009
L-thyroxine
-
type II, thymus
0.009
L-thyroxine
-
0.0105 mM during hypothyroidism
0.00000101
reverse triiodothyronine
mutant enzyme A131S, in presence of 20 mM dithiothreitol
0.0000089
reverse triiodothyronine
wild-type enzyme, in presence of 20 mM dithiothreitol
0.0000098
reverse triiodothyronine
mutant enzyme A131C, in presence of 20 mM dithiothreitol
0.00036
reverse triiodothyronine
-
-
0.015
reverse triiodothyronine
-
wild-type enzyme
0.00003
thyroxine
-
additional information
additional information
-
-
-
additional information
additional information
mutant enzymes S101A/S176A and Y209F/Y217F show KM-values above 0.005 mM
-
additional information
additional information
-
review on enzyme isoforms type I and II and 5-deiodinase, type III
-
additional information
additional information
-
review on enzyme isoforms type I and II and 5-deiodinase, type III
-
additional information
additional information
-
review on enzyme isoforms type I and II and 5-deiodinase, type III
-
additional information
additional information
-
review on enzyme isoforms type I and II and 5-deiodinase, type III
-