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Literature summary for 1.21.99.4 extracted from

  • Molinero, P.; Osuna, C.; Guerrero, J.M.
    Type II thyroxine 5'-deiodinase in the rat thymus (1995), J. Endocrinol., 146, 105-111.
    View publication on PubMed
Search for more literature for 1.21.99.4

Activating Compound

Activating Compound Comment Organism Structure
dithiothreitol high concentrations increase type II activity Rattus sp.
isoproterenol type II Rattus sp.
additional information hypothyroidism enhances type II activity and decreases type I activity Rattus sp.

Inhibitors

Inhibitors Comment Organism Structure
6-Propyl-2-thiouracil inhibits selectively only thyronine 5'-deiodinase type I activity not type II activity Rattus sp.
ipanoic acid type II Rattus sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.009
-
 L-thyroxine DTT 20 mM Rattus sp.
0.009
-
 L-thyroxine type II, thymus Rattus sp.
0.009
-
 L-thyroxine 0.0105 mM during hypothyroidism Rattus sp.

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane type II in membranes of stromal cells and thymocytes Rattus sp. 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-thyroxine + AH2 Rattus sp. thyronine 5'-deiodinase type II 3,3',5-triiodothyronine + iodide + A + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus sp.
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus sp.

Source Tissue

Source Tissue Comment Organism Textmining
additional information no type II activity in spleen Rattus sp.
-
thymus thyronine 5'-deiodinase type II Rattus sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-thyroxine + AH2 thyronine 5'-deiodinase type II Rattus sp. 3,3',5-triiodothyronine + iodide + A + H+
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
 Rattus sp.

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
 Rattus sp.