1.21.99.4: thyroxine 5'-deiodinase

This is an abbreviated version!
For detailed information about thyroxine 5'-deiodinase, go to the full flat file.

Word Map on EC 1.21.99.4

1.21.99.4

thyroid

triiodothyronine

hypothyroidism

tsh

deiodination

adipose

pituitary

selenium

euthyroidism

selenoproteins

3,5,3'-triiodothyronine

thyrotropin

prohormone

thermogenesis

selenoenzyme

propylthiouracil

photoperiodic

hypothalamic

hypothalamic-pituitary-thyroid

selenocysteine

thyroid-stimulating

thyrotropin-releasing

iopanoic

thermogenic

iodotyrosine

hypophysiotropic

t3-dependent

polybrominated

extrathyroidal

hypothyroxinemia

3,3',5-triiodothyronine

thyroxine-binding

mediobasal

pbdes

5'-deiodination

iodine-deficient

tanycytes

tuberalis

debromination

selenocysteine-containing

trbeta

methimazole

thyrotoxicosis

hormone-activating

thyroperoxidase

monocarboxylate

nonthyroidal

secis

levothyroxine

medicine

selenium-deficient

Reaction

Synonyms

5DI , 5DII , 5DIII , D1 5'-deiodinase, D2 5'-deiodinase, deiodinase, diiodothyronine 5'-deiodinase, Dio, DIO1, DIO2, DIOI , DIOII , DIOIII , EC 1.97.1.10, EC 3.8.1.4, ID-1, ID-2, ID-3, iodothyronine 5'-deiodinase, Iodothyronine 5'-monodeiodinase, iodothyronine 5-deiodinase, iodothyronine deiodinase 2, iodothyronine deiodinase D2, iodothyronine inner ring monodeiodinase, iodothyronine outer ring monodeiodinase, L-thyroxine iodohydrolase (reducing), thyroxine 5-deiodinase, Thyroxine deiodinase, type 1 5'-deiodinase, type 1 deiodinase, Type 1 DI , type 1 iodothyronine deiodinase, type 2 5'-deiodinase, type 2 deiodinase, Type 2 DI , type 2 iodothyronine deiodinase, type 3 deiodinase, Type 3 DI , type I iodothyronine 5'-deiodinase, type I iodothyronine deiodinase, type I-like deiodinase, type II iodothyronine deiodinase, type II-like deiodinase, Type-I 5'deiodinase , Type-II 5'deiodinase , Type-III 5'deiodinase , types 1 iodothyronine selenodeiodinase, types 2 iodothyronine selenodeiodinase, XL-15

ECTree

1 Oxidoreductases

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.99 With unknown physiological acceptors

1.21.99.4 thyroxine 5'-deiodinase

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Results	in table
59	Activating Compound
30	AA Sequence
8	Application
1	CAS Registry Number
19	Cloned(Commentary)
18	Cofactor
908	Disease/ Diagnostics
22	Expression
16	General Information
4	General Stability
26	IC50 Value
91	Inhibitors
79	KM Value [mM]
35	Localization
7	Metals/Ions
12	Molecular Weight [Da]
71	Natural Substrates/ Products (Substrates)
239	Organism
2	Pathway
17	pH Optimum
1	pH Range
4	Posttranslational Modification
15	Protein Variants
4	Purification (Commentary)
16	Reaction
2	Reaction Type
94	Reference
1	Renatured (Commentary)
213	Source Tissue
54	Specific Activity [micromol/min/mg]
1	Storage Stability
127	Substrates and Products (Substrate)
19	Subunits
118	Synonyms
1	Systematic Name
15	Temperature Optimum [°C]
3	Temperature Stability [°C]
3	Turnover Number [1/s]

Synonyms

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Synonyms on EC 1.21.99.4 - thyroxine 5'-deiodinase

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5DI

5DII

5DIII

D1 5'-deiodinase

D2 5'-deiodinase

deiodinase

diiodothyronine 5'-deiodinase

Dio

2 entries

DIO1

3 entries

DIO2

5 entries

DIOI

DIOII

DIOIII

EC 1.97.1.10

formerly

EC 3.8.1.4

formerly

ID-1

ID-2

ID-3

iodothyronine 5'-deiodinase

6 entries

Iodothyronine 5'-monodeiodinase

Rattus sp.

isoenzyme type I

639412

iodothyronine 5-deiodinase

Rattus sp.

iodothyronine 5-deiodinase type

639400

iodothyronine deiodinase 2

Rattus norvegicus

745617

iodothyronine deiodinase D2

Homo sapiens

744792

iodothyronine inner ring monodeiodinase

2 entries

iodothyronine outer ring monodeiodinase

L-thyroxine iodohydrolase (reducing)

thyroxine 5-deiodinase

Thyroxine deiodinase

type 1 5'-deiodinase

Homo sapiens

699169

type 1 deiodinase

3 entries

Type 1 DI

type 1 iodothyronine deiodinase

type 2 5'-deiodinase

type 2 deiodinase

Type 2 DI

type 2 iodothyronine deiodinase

5 entries

type 3 deiodinase

Homo sapiens

713764

Type 3 DI

type I iodothyronine 5'-deiodinase

Mus musculus

700655

type I iodothyronine deiodinase

4 entries

type I-like deiodinase

Crocodylus porosus

658810

type II iodothyronine deiodinase

3 entries

type II-like deiodinase

Crocodylus porosus

658810

Type-I 5'deiodinase

Type-II 5'deiodinase

Type-III 5'deiodinase

types 1 iodothyronine selenodeiodinase

Homo sapiens

P49895

658560

types 2 iodothyronine selenodeiodinase

Homo sapiens

Q92813

658560

XL-15