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Literature summary for 1.21.99.4 extracted from

  • Shepherdley, C.A.; Richardson, S.J.; Evans, B.K.; Kuehn, E.R.; Darras, V.M.
    Characterization of outer ring iodothyronine deiodinases in tissues of the saltwater crocodile (Crocodylus porosus) (2002), Gen. Comp. Endocrinol., 125, 387-398.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
dithiothreitol 10 mM required Crocodylus porosus
dithiothreitol type II-like enzyme from liver microsomes: 15 mM required. Type II-like enzyme from gut and kidney microsomes: 20 mM required Crocodylus porosus

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by propylthiouracil, type II-like enzyme Crocodylus porosus
propylthiouracil
-
Crocodylus porosus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Crocodylus porosus
0.00256
-
3,3',5-triiodothyronine type I-like activity in kidney microsomes Crocodylus porosus
0.005
-
3,3',5-triiodothyronine type I-like activity in liver microsomes Crocodylus porosus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Crocodylus porosus
-
-

Organism

Organism UniProt Comment Textmining
Crocodylus porosus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
gut low type I-like activity, type II-like activity is the predominant activity Crocodylus porosus
-
gut type II-like activity is the predominant activity Crocodylus porosus
-
kidney type I-like activity Crocodylus porosus
-
liver low type II-like activity, type I-like activity is the predominant activity Crocodylus porosus
-
liver type I-like activity is the predominant activity Crocodylus porosus
-
additional information no type-II-like activity in kidney Crocodylus porosus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,3',5-triiodothyronine + AH2 rT3 ORD activity Crocodylus porosus 3,3'-diiodothyronine + iodide + A + H+
-
?
L-thyroxine + AH2 outer ring iodothyronine deiodinase activity, T4 ORD activity Crocodylus porosus 3,3',5-triiodothyronine + iodide + A + H+
-
?

Synonyms

Synonyms Comment Organism
type I-like deiodinase
-
Crocodylus porosus
type II-like deiodinase
-
Crocodylus porosus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25 30 T4 ORD activity of type II-like enzyme from gut and kidney microsomes Crocodylus porosus
30 35 rT3 ORD activity of type I-like enzýme Crocodylus porosus
30 35 T4 ORD activity of type II-like enzyme from liver microsomes Crocodylus porosus