Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dithiothreitol | high concentrations of cofactor increases type I activity | Rattus sp. | |
additional information | no effect of insulin and dexamethasone on type I activity | Rattus sp. | |
reduced thiols | e.g. dithiothreitol | Rattus sp. |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-Propyl-2-thiouracil | inhibits selectively only thyronine 5'-deiodinase type I activity not type II activity | Rattus sp. | |
additional information | 3,3',5'-triiodothyronine blocks 5'-deiodination of L-thyroxine blocks 5'-deiodination of 3,3',5'-triiodothyronine | Rattus sp. |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.065 | - |
3,3',5'-triiodothyronine | DTT 10 mM | Rattus sp. | |
0.065 | - |
3,3',5'-triiodothyronine | type I, myocardial | Rattus sp. |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,3',5'-triiodothyronine + AH2 | Rattus sp. | - |
3,3'-diiodothyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | Rattus sp. | - |
3,3',5'-triiodothyronine + iodide + A + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus sp. | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
myocardium | thyronine 5'-deiodinase type I | Rattus sp. | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,3',5'-triiodothyronine + AH2 | - |
Rattus sp. | 3,3'-diiodothyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | - |
Rattus sp. | 3,3',5'-triiodothyronine + iodide + A + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
iodothyronine 5'-deiodinase | type I, selenoprotein, inducible by T3 (higher synthesis) and angiotensin II (positive chronotropic effect in myocard) | Rattus sp. |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
4 | - |
inactivation after 30 min | Rattus sp. |
56 | - |
inactivation after 30 min | Rattus sp. |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | 7.4 | - |
Rattus sp. |