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Literature summary for 1.21.99.4 extracted from

  • Mori, Y.; Nishikawa, M.; Toyoda, N.; Yonemoto, T.; Matsubara, H.; Inada, M.
    Iodothyronine 5'-deiodinase activity in cultured rat myocardial cells: characteristics and effects of triiodothyronine and angiotensin II (1991), Endocrinology, 128, 3105-3112.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
dithiothreitol high concentrations of cofactor increases type I activity Rattus sp.
additional information no effect of insulin and dexamethasone on type I activity Rattus sp.
reduced thiols e.g. dithiothreitol Rattus sp.

Inhibitors

Inhibitors Comment Organism Structure
6-Propyl-2-thiouracil inhibits selectively only thyronine 5'-deiodinase type I activity not type II activity Rattus sp.
additional information 3,3',5'-triiodothyronine blocks 5'-deiodination of L-thyroxine blocks 5'-deiodination of 3,3',5'-triiodothyronine Rattus sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.065
-
3,3',5'-triiodothyronine DTT 10 mM Rattus sp.
0.065
-
3,3',5'-triiodothyronine type I, myocardial Rattus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3,3',5'-triiodothyronine + AH2 Rattus sp.
-
3,3'-diiodothyronine + iodide + A + H+
-
?
L-thyroxine + AH2 Rattus sp.
-
3,3',5'-triiodothyronine + iodide + A + H+
-
?

Organism

Organism UniProt Comment Textmining
Rattus sp.
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
myocardium thyronine 5'-deiodinase type I Rattus sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,3',5'-triiodothyronine + AH2
-
Rattus sp. 3,3'-diiodothyronine + iodide + A + H+
-
?
L-thyroxine + AH2
-
Rattus sp. 3,3',5'-triiodothyronine + iodide + A + H+
-
?

Synonyms

Synonyms Comment Organism
iodothyronine 5'-deiodinase type I, selenoprotein, inducible by T3 (higher synthesis) and angiotensin II (positive chronotropic effect in myocard) Rattus sp.

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
4
-
inactivation after 30 min Rattus sp.
56
-
inactivation after 30 min Rattus sp.

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 7.4
-
Rattus sp.