1.1.1.8: glycerol-3-phosphate dehydrogenase (NAD+)

This is an abbreviated version, for detailed information about glycerol-3-phosphate dehydrogenase (NAD+), go to the full flat file.

Reaction

sn-glycerol 3-phosphate
+
acceptor
=
glycerone phosphate
+
reduced acceptor

Synonyms

(NAD+)-dependent G3pdh, (NAD+)-dependent glycerol-3-phosphate dehydrogenase, alpha glycerophosphate dehydrogenase, alpha-glycerol phosphate dehydrogenase (NAD), alpha-glycerophosphate dehydrogenase (NAD), Cagpd1, Cagpd1p, Cagpd2, Cagpd2p, cG3PDH, CgGPD, cGPdH, cytoplasmic NAD-dependent glycerol-3-phosphate dehydrogenase, cytosolic GPDH, dehydrogenase, glycerol phosphate, DhGPD1, G-3-P dehydrogenase, G3P dehydrogenase, G3PD, G3PD1, G3PD2, G3PD3, G3PDH, GDM, GDP2, GLPD, GLY1, glycerol 1-phosphate dehydrogenase, glycerol 3-phosphate dehydrogenase, glycerol 3-phosphate dehydrogenase 1, glycerol phosphate dehydrogenase (NAD), glycerol-3-phosphate dehydrogenase, glycerol-3-phosphate dehydrogenase 1, glycerophosphate dehydrogenase (NAD), GPD, GPD1, Gpd1p, gpd2p, GPDH, GPDH-1, GPDH-2, GPDH1, GPDH2, GPDH3, GPDH: NAD+ 2 oxidoreductase, GPDH: NAD+ 2 oxidorreductase, GPDHc1, hydroglycerophosphate dehydrogenase, L-alpha-glycerol phosphate dehydrogenase, L-alpha-glycerophosphate dehydrogenase, L-glycerol 3-phosphate dehydrogenase, L-glycerol phosphate dehydrogenase, L-glycerophosphate dehydrogenase, mGPDH, NAD+-dependent G3P dehydrogenase, NAD+-dependent glycerol 3-phosphate dehydrogenase, NAD+-dependent glycerol-3-phosphate dehydrogenase, NAD+-GPDH, NAD-alpha-glycerophosphate dehydrogenase, NAD-dependent cG3PDH, NAD-dependent glycerol phosphate dehydrogenase, NAD-dependent glycerol-3-phosphate dehydrogenase, NAD-L-glycerol-3-phosphate dehydrogenase, NAD-linked glycerol 3-phosphate dehydrogenase, NADH-dihydroxyacetone phosphate reductase, NADP+-dependent glycerol 3-phosphate dehydrogenase, SFD1, SFD1/GLY1

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.8 glycerol-3-phosphate dehydrogenase (NAD+)

Expression

Expression on EC 1.1.1.8 - glycerol-3-phosphate dehydrogenase (NAD+)

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
effects of salinity changes on the gene expressions of a (NAD+)-dependent G3pdh among G3pdh isozymes by real-time quantitative PCR, overview. Expression level of G3pdh in Dunaliella salina grown at various salinities is significantly inversely correlated to the salinity, but there is no significant correlation between the expression level of G3pdh and salinity after 2 h of treatment by hyperosmotic or hypoosmotic shock
gene expression level is high after 2 h induction in a hyperosmotic environment containing 2 M NaCl and returns to normal within 6 h
isoform GPDH2 is expressed in response to 200 mM NaCl treatment; isoform GPDH3 is expressed in response to 200 mM NaCl treatment
osmotic stress induces the isozyme; osmotic stress induces the isozyme
porcine GPD1 gene is expressed in almost all tissues but its levels of expression vary widely over 2 orders of magnitude. Longissinus doris muscle and cerebrum have a similar expression pattern that is at a low level at birth and increasing with aging to the highest level at postnatal day 8 in longissinus doris muscle and postnatal day 14 in cerebrum. Weaning decreases the expression level of the GPD1 gene
the enzyme shows higher enzymatic activity in response to osmotic and cold stress. The enzyme expression is increased during fermentation; there is significantly higher enzyme activity after osmotic (2.6, 5.2 and 3.6fold after 2, 4 and 8 h, respectively) and cold stresses (9.7, 19.9 and 2.2fold after 2, 4 and 8 h, respectively)
there is significantly higher enzyme activity after osmotic (2.6, 5.2 and 3.6fold after 2, 4 and 8 h, respectively) and cold stresses (9.7, 19.9 and 2.2fold after 2, 4 and 8 h, respectively)
when the temperature is increased from 22°C to 28°C, the isoform GPDH-1 transcript increases 4times in fifth instar nymphs; when the temperature is increased from 22°C to 28°C, the isoform GPDH-2 transcript decreases 50% in fifth instar nymphs