1.1.1.8: glycerol-3-phosphate dehydrogenase (NAD+)

This is an abbreviated version, for detailed information about glycerol-3-phosphate dehydrogenase (NAD+), go to the full flat file.

Reaction

sn-glycerol 3-phosphate
+
acceptor
=
glycerone phosphate
+
reduced acceptor

Synonyms

(NAD+)-dependent G3pdh, (NAD+)-dependent glycerol-3-phosphate dehydrogenase, alpha glycerophosphate dehydrogenase, alpha-glycerol phosphate dehydrogenase (NAD), alpha-glycerophosphate dehydrogenase (NAD), Cagpd1, Cagpd2, cG3PDH, CgGPD, cGPdH, cytoplasmic NAD-dependent glycerol-3-phosphate dehydrogenase, dehydrogenase, glycerol phosphate, DhGPD1, G-3-P dehydrogenase, G3P dehydrogenase, G3PD, G3PDH, GDM, GDP2, GLPD, glycerol 1-phosphate dehydrogenase, glycerol 3-phosphate dehydrogenase, glycerol 3-phosphate dehydrogenase 1, glycerol phosphate dehydrogenase (NAD), glycerol-3-phosphate dehydrogenase, glycerol-3-phosphate dehydrogenase 1, glycerophosphate dehydrogenase (NAD), GPD, GPD1, GPDH, GPDH-1, GPDH-2, GPDH1, GPDH2, GPDH: NAD+ 2 oxidorreductase, GPDHc1, hydroglycerophosphate dehydrogenase, L-alpha-glycerol phosphate dehydrogenase, L-alpha-glycerophosphate dehydrogenase, L-glycerol 3-phosphate dehydrogenase, L-glycerol phosphate dehydrogenase, L-glycerophosphate dehydrogenase, mGPDH, NAD+-dependent glycerol 3-phosphate dehydrogenase, NAD+-dependent glycerol-3-phosphate dehydrogenase, NAD+-GPDH, NAD-alpha-glycerophosphate dehydrogenase, NAD-dependent cG3PDH, NAD-dependent glycerol phosphate dehydrogenase, NAD-dependent glycerol-3-phosphate dehydrogenase, NAD-L-glycerol-3-phosphate dehydrogenase, NAD-linked glycerol 3-phosphate dehydrogenase, NADH-dihydroxyacetone phosphate reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.8 glycerol-3-phosphate dehydrogenase (NAD+)

Inhibitors

Inhibitors on EC 1.1.1.8 - glycerol-3-phosphate dehydrogenase (NAD+)

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(-)-epigallocatechin-3-gallate
-
noncompetitive
(NH4)2SO4
2,3-Dimercaptopropanol
-
competitive inhibitor to glycerophosphate
2,4-Dichlorophenoxyacetic acid
-
-
2-amino-2-hydroxymethylpropane-1,3-diol
-
i.e. Tris
2-hydroxy-1,2,3-nonadecanetricarboxylic acid
3-morpholinosydnonimine
-
-
adenosine diphosphate ribose
ADP
-
at physiological concentration, 10 mM 90% inhibition
ADP-ribose
-
allosteric inhibitor
Cd2+
-
50% inhibition at 8.33 mM; 50% inhibition at 8.3 mM
Cu2+
-
50% inhibition at 12.96 mM; 50% inhibition at 13.0 mM
dihydroxyacetone phosphate
FeCl2
-
0.5 mM, about 10% residual activity
fructose-1,6-bisphosphate
-
at physiological concentration, non-competitive
glycerol
-
slight inhibition
glycerol phosphate
-
0.025 mM, strong inhibition of chloroplastic and cytosolic form, endproduct inhibition
gymnemic acid
-
may have some pharmacological activities including antidiabetic activity and lipid lowering effects via interaction with G3PDH
iodoacetamide
-
effective inhibitor
iodoacetate
K+
-
50% inhibition at 40.66 mM; 50% inhibition at 40.7 mM
KCl
-
inactivation
L-glycerol 3-phosphate
Large peptide factor
-
chloroplast enzyme
-
linoleic acid
-
0.003 mM, 40% inhibition of chloroplastic form and 43% inhibition of cytosolic form
malate
-
at high concentration
Melarsen oxide
Mn2+
-
50% inhibition at 36.6 mM
N-ethylmaleimide
NADH-X
-
allosteric inhibitor
NADPH
Ni2+
-
50% inhibition at 31.66 mM; 50% inhibition at 31.7 mM
Nucleic acids
-
strongly inhibit
-
o-Iodosobenzoic acid
-
0.5 mM, about 10% residual activity
octyl glucose
-
0.003 mM, 41% inhibition of chloroplastic form and 61% inhibition of cytosolic form
p-chloromercuribenzoate
p-mercuribenzoate
-
0.1 mM complete inhibition
palmitic acid
-
0.003 mM, 40% inhibition of chloroplastic form and 43% inhibition of cytosolic form
phenylmethyl sulfonyl fluoride
-
0.5 mM 50% inhibition of cytosolic form, little effect on chloroplastic form
phosphate
phosphatidyl choline
-
0.003 mM, 42% inhibition of chloroplastic form and 43% inhibition of cytosolic form
phosphogluconate
-
cytosolic isozyme
reduced thioredoxin
-
stimulation of chloroplastic form
S-nitroso-N-acetylpenicillamine
-
-
sedoheptulose 1,7-bisphosphate
-
0.5 mM, chloroplastic and cytosolic form inhibited by 50%
selenocysteine
-
0.015 mM, 10% residual activity
selenomethionine
-
0.015 mM, 40% residual activity
Small peptide factor
-
cytosolic enzyme
-
SO42-
-
at high concentration, MgSO4 most inhibitory
Sodium selenite
-
0.015 mM, 10% residual activity
suramin
Thylakoid fraction
-
0.02 mM 97% inhibition
-
Triton X-100
-
0.006 mM, 50% inhibition of chloroplastic form and 52% inhibition of cytosolic form
Zn2+
-
50% inhibition at 5.66 mM; 50% inhibition at 5.7 mM
ZnCl2
-
0.5 mM, about 10% residual activity
additional information
-