1.1.1.19: glucuronate reductase

This is an abbreviated version, for detailed information about glucuronate reductase, go to the full flat file.

Reaction

L-gulonate
+
NADP+
=
D-glucuronate
+
NADPH
+
H+

Synonyms

AKR1A1, aldehyde reductase, aldehyde reductase II, ALR1, D-glucuronate dehydrogenase, D-glucuronate reductase, D-glucuronic reductase, hexonate dehydrogenase, L-glucuronate reductase, L-gulonate NAD-3-oxidoreductase, L-hexonate:NADP dehydrogenase, More, NADP-L-gulonate dehydrogenase, TPN l-hexonate dehydrogenase, TPN-L-gulonate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.19 glucuronate reductase

pH Optimum

pH Optimum on EC 1.1.1.19 - glucuronate reductase

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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6 - 7
-
DL-glyceraldehyde
6.2 - 6.6
-
D-glucuronate
7
-
shifted pH-optimum for the coupled reaction of oxidation of gamma-hydroxybutyrate and reduction of D-glucuronate in vitro
8
-
assay at, ALR1
8.5
-
substrate L-gulonate or D-glucuronate
8.6 - 9.3
-
-
9
-
substrate gamma-hydroxybutyrate, at pH 7.0 activity is reduced by 50%