Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ATP-ribose | competitive versus NADPH | Homo sapiens | |
menadione | competitive versus D-glucuronate | Homo sapiens | |
pyridoxal 5'-phosphate | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucuronate + NADPH | Homo sapiens | - |
L-gulonate + NADP+ | - |
r | |
L-gulonate + NADP+ | Homo sapiens | - |
D-glucuronate + NADPH | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucuronate + NADPH | - |
Homo sapiens | L-gulonate + NADP+ | - |
r | |
L-gulonate + NADP+ | - |
Homo sapiens | D-glucuronate + NADPH | - |
r |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | 0.119 per mM * s, L-gulonate, steady state kinetic | Homo sapiens | |
additional information | - |
additional information | 10.82 per mM * s, D-glucuronate, steady state kinetic | Homo sapiens | |
additional information | - |
additional information | 1124 per mM * s, NADPH, steady state kinetic | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
substrate L-gulonate or D-glucuronate | Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7 | 10 | - |
Homo sapiens |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
5 | 10.5 | irreversible loss of activity below pH 5.0 and above pH 11 | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |