1.1.1.19: glucuronate reductase

This is an abbreviated version, for detailed information about glucuronate reductase, go to the full flat file.

Reaction

L-gulonate
+
NADP+
=
D-glucuronate
+
NADPH
+
H+

Synonyms

AKR1A1, aldehyde reductase, aldehyde reductase II, ALR1, D-glucuronate dehydrogenase, D-glucuronate reductase, D-glucuronic reductase, hexonate dehydrogenase, L-glucuronate reductase, L-gulonate NAD-3-oxidoreductase, L-hexonate:NADP dehydrogenase, More, NADP-L-gulonate dehydrogenase, TPN l-hexonate dehydrogenase, TPN-L-gulonate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.19 glucuronate reductase

Disease

Disease on EC 1.1.1.19 - glucuronate reductase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Ascorbic Acid Deficiency
A novel osteoporosis model with ascorbic acid deficiency in Akr1A1 gene knockout mice.
Astrocytoma
The role of aldehyde reductase AKR1A1 in the metabolism of gamma-hydroxybutyrate in 1321N1 human astrocytoma cells.
[Effect of AKR1A1 knock-down on H2;O2; and 4-hydroxynonenal-induced cytotoxicity in human 1321N1 astrocytoma cells].
Carcinoma, Hepatocellular
Metabolism of gamma hydroxybutyrate in human hepatoma HepG2 cells by the aldo-keto reductase AKR1A1.
Diabetes Mellitus, Type 2
Activities of aldose reductase, ATPases, and nucleotide concentrations of erythrocytes in patients with type 2 (non-insulin-dependent) diabetes mellitus.
Laryngeal Neoplasms
Increased aldehyde reductase expression mediates acquired radioresistance of laryngeal cancer cells via modulating p53.
Liver Diseases, Alcoholic
Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members.
Lymphoma, Non-Hodgkin
Genetic Polymorphisms in Oxidative Stress Pathway Genes and Modification of BMI and Risk of Non-Hodgkin Lymphoma.
Neoplasms
Quantitative analysis of the human AKR family members in cancer cell lines using the mTRAQ/MRM approach.
The role of cytochromes p450 and aldo-keto reductases in prognosis of breast carcinoma patients.
Osteoporosis
A novel osteoporosis model with ascorbic acid deficiency in Akr1A1 gene knockout mice.