1.1.1.19: glucuronate reductase
This is an abbreviated version!
For detailed information about glucuronate reductase, go to the full flat file.
Word Map on EC 1.1.1.19
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1.1.1.19
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aldo-keto
-
aldose
-
sorbinil
-
akr1b1s
-
o-quinones
-
alrestatin
-
1.1.1.21
-
daunorubicinol
-
trans-dihydrodiols
-
statil
-
akr7a2
-
dl-glyceraldehyde
-
3alpha-hydroxysteroid
-
diol-epoxide
- 1.1.1.19
-
aldo-keto
- aldose
- sorbinil
- akr1b1s
- o-quinones
- alrestatin
-
1.1.1.21
- daunorubicinol
-
trans-dihydrodiols
- statil
-
akr7a2
- dl-glyceraldehyde
-
3alpha-hydroxysteroid
-
diol-epoxide
Reaction
Synonyms
AKR1A1, aldehyde reductase, aldehyde reductase II, ALR1, D-glucuronate dehydrogenase, D-glucuronate reductase, D-glucuronic reductase, galacturonate oxidoreductase, hexonate dehydrogenase, L-glucuronate reductase, L-gulonate NAD-3-oxidoreductase, L-hexonate:NADP dehydrogenase, More, NADP-L-gulonate dehydrogenase, PcGOR, TPN l-hexonate dehydrogenase, TPN-L-gulonate dehydrogenase
ECTree
1.1.1.19 glucuronate reductaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 1.1.1.19 - glucuronate reductase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4-nitrobenzaldehyde + NADPH
4-nitrobenzyl alcohol + NADP+
-
2-, and 3-isomer also reduced
-
-
r
D-aldose + NADPH
L-alditol + NADP+
-
i.e. D-xylose, D-glucose, D-galactose are reduced with 100fold less active than D-glucuronate
-
-
r
D-galacturonate + NADH + H+
L-galactonate + NAD+
the enzyme is active on both glucuronic acid and galacturonic acid, with similar substrate specificities (kcat/Km) using the preferred co-substrate NADPH
-
-
?
D-galacturonate + NADH + H+
L-galactonate + NAD+
the enzyme is active on both glucuronic acid and galacturonic acid, with similar substrate specificities (kcat/Km) using the preferred co-substrate NADPH
-
-
?
D-galacturonate + NADPH + H+
L-galactonate + NADP+
the enzyme is active on both glucuronic acid and galacturonic acid, with similar substrate specificities (kcat/Km) using the preferred co-substrate NADPH
-
-
?
D-galacturonate + NADPH + H+
L-galactonate + NADP+
the enzyme is active on both glucuronic acid and galacturonic acid, with similar substrate specificities (kcat/Km) using the preferred co-substrate NADPH
-
-
?
D-glucuronate + NADH + H+
D-gulonate + NADH + H+
the enzyme is active on both glucuronic acid and galacturonic acid, with similar substrate specificities (kcat/Km) using the preferred co-substrate NADPH
-
-
?
D-glucuronate + NADH + H+
D-gulonate + NADH + H+
the enzyme is active on both glucuronic acid and galacturonic acid, with similar substrate specificities (kcat/Km) using the preferred co-substrate NADPH
-
-
?
D-glucuronate + NADPH
L-gulonate + NADP+
-
-
-
-
r
D-glucuronate + NADPH
L-gulonate + NADP+
-
a step in ascorbic acid biosynthesis, overview
-
-
r
D-glucuronate + NADPH + H+
L-gulonate + NADP+
the enzyme is active on both glucuronic acid and galacturonic acid, with similar substrate specificities (kcat/Km) using the preferred co-substrate NADPH
-
-
?
D-glucuronate + NADPH + H+
L-gulonate + NADP+
the enzyme is active on both glucuronic acid and galacturonic acid, with similar substrate specificities (kcat/Km) using the preferred co-substrate NADPH
-
-
?
D-glucurono-3,6-lactone + NADPH + H+
L-gulono-1,4-lactone
-
-
-
?
D-glucurono-3,6-lactone + NADPH + H+
L-gulono-1,4-lactone
-
-
-
?
gamma-hydroxybutyrate + NADP+
succinic semialdehyde + NADPH
-
-
-
-
?
gamma-hydroxybutyrate + NADP+
succinic semialdehyde + NADPH
-
preverably in a coupled reaction in vivo with reduction of D-glucuronate
-
-
?
L-gulonate + NADP+
D-glucuronate + NADPH
-
-
-
-
r
additional information
?
-
-
coupled gamma-hydroxybutyrate oxidation and D-glucuronate reduction
-
-
?
additional information
?
-
-
reduction of aldehyde greatly favored compared to oxidation of alcohol
-
-
?
additional information
?
-
-
no reaction with gamma-lactones of the substrates
-
-
?
additional information
?
-
-
reduction of D-glyceraldehyde: pro-4R hydrogen is transferred from NADPH, i.e. A-specific, attacks re face of carbonyl group of the D-glyceraldehyde
-
-
?
